[ { "phenotype_id": "PH4093", "phenotype_version_id": 9311, "name": "Alcohol Problems", "definition": "Regular consumption of alcohol above recommended levels\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:05:26.221073Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:05:26.212356Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Alcoholism (disorder)", "value": 498320 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 9562, "concept_version_id": 17047, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4093", "phenotype_version_id": 9311, "phenotype_name": "Alcohol Problems", "code_attribute_header": [ "type" ], "codes": [ { "code": "1408", "description": "alcohol dependency", "attributes": { "type": "any" } }, { "code": "1604", "description": "alcoholic liver disease / alcoholic cirrhosis", "attributes": { "type": "any" } } ] }, { "concept_id": 9563, "concept_version_id": 17048, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4093", "phenotype_version_id": 9311, "phenotype_name": "Alcohol Problems", "code_attribute_header": [ "type" ], "codes": [ { "code": "E24.4", "description": "Alcohol-induced pseudo-Cushing's syndrome", "attributes": { "type": "any" } }, { "code": "F10.1", "description": "Mental and behavioural disorders due to use of alcohol - Harmful use", "attributes": { "type": "any" } }, { "code": "F10.2", "description": "Mental and behavioural disorders due to use of alcohol - Dependence syndrome", "attributes": { "type": "any" } }, { "code": "F10.3", "description": "Mental and behavioural disorders due to use of alcohol - Withdrawal state", "attributes": { "type": "any" } }, { "code": "F10.4", "description": "Mental and behavioural disorders due to use of alcohol - Withdrawal state with delirium", "attributes": { "type": "any" } }, { "code": "F10.5", "description": "Mental and behavioural disorders due to use of alcohol - Psychotic disorder", "attributes": { "type": "any" } }, { "code": "F10.6", "description": "Mental and behavioural disorders due to use of alcohol - Amnesic syndrome", "attributes": { "type": "any" } }, { "code": "F10.7", "description": "Mental and behavioural disorders due to use of alcohol - Residual and late-onset psychotic disorder", "attributes": { "type": "any" } }, { "code": "F10.8", "description": "Mental and behavioural disorders due to use of alcohol - Other mental and behavioural disorders", "attributes": { "type": "any" } }, { "code": "F10.9", "description": "Mental and behavioural disorders due to use of alcohol - Unspecified mental and behavioural disorder", "attributes": { "type": "any" } }, { "code": "G31.2", "description": "Degeneration of nervous system due to alcohol", "attributes": { "type": "any" } }, { "code": "G62.1", "description": "Alcoholic polyneuropathy", "attributes": { "type": "any" } }, { "code": "G72.1", "description": "Alcoholic myopathy", "attributes": { "type": "any" } }, { "code": "I42.6", "description": "Alcoholic cardiomyopathy", "attributes": { "type": "any" } }, { "code": "K29.2", "description": "Alcoholic gastritis", "attributes": { "type": "any" } }, { "code": "K70", "description": "Alcoholic liver disease", "attributes": { "type": "any" } }, { "code": "K85.2", "description": "Alcohol-induced acute pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.0", "description": "Alcohol-induced chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "Z50.2", "description": "Alcohol rehabilitation", "attributes": { "type": "any" } }, { "code": "Z71.4", "description": "Alcohol abuse counselling and surveillance", "attributes": { "type": "any" } } ] }, { "concept_id": 9564, "concept_version_id": 17049, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4093", "phenotype_version_id": 9311, "phenotype_name": "Alcohol Problems", "code_attribute_header": [ "type" ], "codes": [ { "code": "E24.4", "description": "Alcohol-induced pseudo-Cushing's syndrome", "attributes": { "type": "any" } }, { "code": "F10.1", "description": "Mental and behavioural disorders due to use of alcohol - Harmful use", "attributes": { "type": "any" } }, { "code": "F10.2", "description": "Mental and behavioural disorders due to use of alcohol - Dependence syndrome", "attributes": { "type": "any" } }, { "code": "F10.3", "description": "Mental and behavioural disorders due to use of alcohol - Withdrawal state", "attributes": { "type": "any" } }, { "code": "F10.4", "description": "Mental and behavioural disorders due to use of alcohol - Withdrawal state with delirium", "attributes": { "type": "any" } }, { "code": "F10.5", "description": "Mental and behavioural disorders due to use of alcohol - Psychotic disorder", "attributes": { "type": "any" } }, { "code": "F10.6", "description": "Mental and behavioural disorders due to use of alcohol - Amnesic syndrome", "attributes": { "type": "any" } }, { "code": "F10.7", "description": "Mental and behavioural disorders due to use of alcohol - Residual and late-onset psychotic disorder", "attributes": { "type": "any" } }, { "code": "F10.8", "description": "Mental and behavioural disorders due to use of alcohol - Other mental and behavioural disorders", "attributes": { "type": "any" } }, { "code": "F10.9", "description": "Mental and behavioural disorders due to use of alcohol - Unspecified mental and behavioural disorder", "attributes": { "type": "any" } }, { "code": "G31.2", "description": "Degeneration of nervous system due to alcohol", "attributes": { "type": "any" } }, { "code": "G62.1", "description": "Alcoholic polyneuropathy", "attributes": { "type": "any" } }, { "code": "G72.1", "description": "Alcoholic myopathy", "attributes": { "type": "any" } }, { "code": "I42.6", "description": "Alcoholic cardiomyopathy", "attributes": { "type": "any" } }, { "code": "K29.2", "description": "Alcoholic gastritis", "attributes": { "type": "any" } }, { "code": "K70", "description": "Alcoholic liver disease", "attributes": { "type": "any" } }, { "code": "K85.2", "description": "Alcohol-induced acute pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.0", "description": "Alcohol-induced chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "Z50.2", "description": "Alcohol rehabilitation", "attributes": { "type": "any" } }, { "code": "Z71.4", "description": "Alcohol abuse counselling and surveillance", "attributes": { "type": "any" } } ] }, { "concept_id": 9565, "concept_version_id": 17050, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4093", "phenotype_version_id": 9311, "phenotype_name": "Alcohol Problems", "code_attribute_header": [ "type" ], "codes": [ { "code": "E24.4", "description": "Alcohol-induced pseudo-Cushing's syndrome", "attributes": { "type": "any" } }, { "code": "F10.1", "description": "Mental and behavioural disorders due to use of alcohol - Harmful use", "attributes": { "type": "any" } }, { "code": "F10.2", "description": "Mental and behavioural disorders due to use of alcohol - Dependence syndrome", "attributes": { "type": "any" } }, { "code": "F10.3", "description": "Mental and behavioural disorders due to use of alcohol - Withdrawal state", "attributes": { "type": "any" } }, { "code": "F10.4", "description": "Mental and behavioural disorders due to use of alcohol - Withdrawal state with delirium", "attributes": { "type": "any" } }, { "code": "F10.5", "description": "Mental and behavioural disorders due to use of alcohol - Psychotic disorder", "attributes": { "type": "any" } }, { "code": "F10.6", "description": "Mental and behavioural disorders due to use of alcohol - Amnesic syndrome", "attributes": { "type": "any" } }, { "code": "F10.7", "description": "Mental and behavioural disorders due to use of alcohol - Residual and late-onset psychotic disorder", "attributes": { "type": "any" } }, { "code": "F10.8", "description": "Mental and behavioural disorders due to use of alcohol - Other mental and behavioural disorders", "attributes": { "type": "any" } }, { "code": "F10.9", "description": "Mental and behavioural disorders due to use of alcohol - Unspecified mental and behavioural disorder", "attributes": { "type": "any" } }, { "code": "G31.2", "description": "Degeneration of nervous system due to alcohol", "attributes": { "type": "any" } }, { "code": "G62.1", "description": "Alcoholic polyneuropathy", "attributes": { "type": "any" } }, { "code": "G72.1", "description": "Alcoholic myopathy", "attributes": { "type": "any" } }, { "code": "I42.6", "description": "Alcoholic cardiomyopathy", "attributes": { "type": "any" } }, { "code": "K29.2", "description": "Alcoholic gastritis", "attributes": { "type": "any" } }, { "code": "K70", "description": "Alcoholic liver disease", "attributes": { "type": "any" } }, { "code": "K85.2", "description": "Alcohol-induced acute pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.0", "description": "Alcohol-induced chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "Z50.2", "description": "Alcohol rehabilitation", "attributes": { "type": "any" } }, { "code": "Z71.4", "description": "Alcohol abuse counselling and surveillance", "attributes": { "type": "any" } } ] }, { "concept_id": 9566, "concept_version_id": 17051, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4093", "phenotype_version_id": 9311, "phenotype_name": "Alcohol Problems", "code_attribute_header": [ "type" ], "codes": [ { "code": "E24.4", "description": "Alcohol-induced pseudo-Cushing's syndrome", "attributes": { "type": "any" } }, { "code": "F10.1", "description": "Mental and behavioural disorders due to use of alcohol - Harmful use", "attributes": { "type": "any" } }, { "code": "F10.2", "description": "Mental and behavioural disorders due to use of alcohol - Dependence syndrome", "attributes": { "type": "any" } }, { "code": "F10.3", "description": "Mental and behavioural disorders due to use of alcohol - Withdrawal state", "attributes": { "type": "any" } }, { "code": "F10.4", "description": "Mental and behavioural disorders due to use of alcohol - Withdrawal state with delirium", "attributes": { "type": "any" } }, { "code": "F10.5", "description": "Mental and behavioural disorders due to use of alcohol - Psychotic disorder", "attributes": { "type": "any" } }, { "code": "F10.6", "description": "Mental and behavioural disorders due to use of alcohol - Amnesic syndrome", "attributes": { "type": "any" } }, { "code": "F10.7", "description": "Mental and behavioural disorders due to use of alcohol - Residual and late-onset psychotic disorder", "attributes": { "type": "any" } }, { "code": "F10.8", "description": "Mental and behavioural disorders due to use of alcohol - Other mental and behavioural disorders", "attributes": { "type": "any" } }, { "code": "F10.9", "description": "Mental and behavioural disorders due to use of alcohol - Unspecified mental and behavioural disorder", "attributes": { "type": "any" } }, { "code": "G31.2", "description": "Degeneration of nervous system due to alcohol", "attributes": { "type": "any" } }, { "code": "G62.1", "description": "Alcoholic polyneuropathy", "attributes": { "type": "any" } }, { "code": "G72.1", "description": "Alcoholic myopathy", "attributes": { "type": "any" } }, { "code": "I42.6", "description": "Alcoholic cardiomyopathy", "attributes": { "type": "any" } }, { "code": "K29.2", "description": "Alcoholic gastritis", "attributes": { "type": "any" } }, { "code": "K70", "description": "Alcoholic liver disease", "attributes": { "type": "any" } }, { "code": "K85.2", "description": "Alcohol-induced acute pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.0", "description": "Alcohol-induced chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "Z50.2", "description": "Alcohol rehabilitation", "attributes": { "type": "any" } }, { "code": "Z71.4", "description": "Alcohol abuse counselling and surveillance", "attributes": { "type": "any" } } ] }, { "concept_id": 9567, "concept_version_id": 17052, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4093", "phenotype_version_id": 9311, "phenotype_name": "Alcohol Problems", "code_attribute_header": [ "type" ], "codes": [ { "code": "136S.00", "description": "Hazardous alcohol use", "attributes": { "type": "any" } }, { "code": "136T.00", "description": "Harmful alcohol use", "attributes": { "type": "any" } }, { "code": "136W.00", "description": "Alcohol misuse", "attributes": { "type": "any" } }, { "code": "13Y8.00", "description": "Alcoholics anonymous", "attributes": { "type": "any" } }, { "code": "1462.00", "description": "H/O: alcoholism", "attributes": { "type": "prevalent" } }, { "code": "1B1c.00", "description": "Alcohol induced hallucinations", "attributes": { "type": "any" } }, { "code": "66e..00", "description": "Alcohol disorder monitoring", "attributes": { "type": "prevalent" } }, { "code": "66e0.00", "description": "Alcohol abuse monitoring", "attributes": { "type": "prevalent" } }, { "code": "7P22100", "description": "Delivery of rehabilitation for alcohol addiction", "attributes": { "type": "any" } }, { "code": "8BA8.00", "description": "Alcohol detoxification", "attributes": { "type": "any" } }, { "code": "8CAv.00", "description": "Advised to contact primary care alcohol worker", "attributes": { "type": "any" } }, { "code": "8G32.00", "description": "Aversion therapy - alcoholism", "attributes": { "type": "any" } }, { "code": "8H35.00", "description": "Admitted to alcohol detoxification centre", "attributes": { "type": "any" } }, { "code": "8H7p.00", "description": "Referral to community alcohol team", "attributes": { "type": "any" } }, { "code": "8HkG.00", "description": "Referral to specialist alcohol treatment service", "attributes": { "type": "any" } }, { "code": "8HkJ.00", "description": "Referral to alcohol brief intervention service", "attributes": { "type": "any" } }, { "code": "9k1..00", "description": "Alcohol misuse - enhanced services administration", "attributes": { "type": "any" } }, { "code": "9k12.00", "description": "Alcohol misuse - enhanced service completed", "attributes": { "type": "any" } }, { "code": "9k1A.00", "description": "Brief intervention for excessive alcohol consumptn completed", "attributes": { "type": "any" } }, { "code": "9k1B.00", "description": "Extended intervention for excessive alcohol consumptn complt", "attributes": { "type": "any" } }, { "code": "9NN2.00", "description": "Under care of community alcohol team", "attributes": { "type": "any" } }, { "code": "C150500", "description": "Alcohol-induced pseudo-Cushing's syndrome", "attributes": { "type": "any" } }, { "code": "C251.11", "description": "Wernicke's encephalopathy", "attributes": { "type": "any" } }, { "code": "C253.00", "description": "Wernicke's encephalopathy", "attributes": { "type": "any" } }, { "code": "E01..00", "description": "Alcoholic psychoses", "attributes": { "type": "any" } }, { "code": "E010.00", "description": "Alcohol withdrawal delirium", "attributes": { "type": "any" } }, { "code": "E010.11", "description": "DTs - delirium tremens", "attributes": { "type": "any" } }, { "code": "E010.12", "description": "Delirium tremens", "attributes": { "type": "any" } }, { "code": "E011.00", "description": "Alcohol amnestic syndrome", "attributes": { "type": "any" } }, { "code": "E011000", "description": "Korsakov's alcoholic psychosis", "attributes": { "type": "any" } }, { "code": "E011100", "description": "Korsakov's alcoholic psychosis with peripheral neuritis", "attributes": { "type": "any" } }, { "code": "E011200", "description": "Wernicke-Korsakov syndrome", "attributes": { "type": "any" } }, { "code": "E011z00", "description": "Alcohol 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"Alcohol dependence syndrome", "attributes": { "type": "any" } }, { "code": "E230.00", "description": "Acute alcoholic intoxication in alcoholism", "attributes": { "type": "any" } }, { "code": "E230000", "description": "Acute alcoholic intoxication, unspecified, in alcoholism", "attributes": { "type": "any" } }, { "code": "E230100", "description": "Continuous acute alcoholic intoxication in alcoholism", "attributes": { "type": "any" } }, { "code": "E230.11", "description": "Alcohol dependence with acute alcoholic intoxication", "attributes": { "type": "any" } }, { "code": "E230200", "description": "Episodic acute alcoholic intoxication in alcoholism", "attributes": { "type": "any" } }, { "code": "E230300", "description": "Acute alcoholic intoxication in remission, in alcoholism", "attributes": { "type": "any" } }, { "code": "E230z00", "description": "Acute alcoholic intoxication in alcoholism NOS", "attributes": { "type": "any" } }, { "code": "E231.00", "description": "Chronic alcoholism", "attributes": { "type": "any" } }, { "code": "E231000", "description": "Unspecified chronic alcoholism", "attributes": { "type": "any" } }, { "code": "E23..11", "description": "Alcoholism", "attributes": { "type": "any" } }, { "code": "E231100", "description": "Continuous chronic alcoholism", "attributes": { "type": "any" } }, { "code": "E231.11", "description": "Dipsomania", "attributes": { "type": "any" } }, { "code": "E23..12", "description": "Alcohol problem drinking", "attributes": { "type": "any" } }, { "code": "E231200", "description": "Episodic chronic alcoholism", "attributes": { "type": "any" } }, { "code": "E231300", "description": "Chronic alcoholism in remission", "attributes": { "type": "any" } }, { "code": "E231z00", "description": "Chronic alcoholism NOS", "attributes": { "type": "any" } }, { "code": "E23z.00", "description": "Alcohol dependence syndrome NOS", "attributes": { "type": "any" } }, { "code": "Eu10.00", "description": "[X]Mental and behavioural disorders due to use of alcohol", "attributes": { "type": "any" } }, { "code": "Eu10100", "description": "[X]Mental and behav dis due to use of alcohol: harmful use", "attributes": { "type": "any" } }, { "code": "Eu10200", "description": "[X]Mental and behav dis due to use alcohol: dependence syndr", "attributes": { "type": "any" } }, { "code": "Eu10211", "description": "[X]Alcohol addiction", "attributes": { "type": "any" } }, { "code": "Eu10212", "description": "[X]Chronic alcoholism", "attributes": { "type": "any" } }, { "code": "Eu10213", "description": "[X]Dipsomania", "attributes": { "type": "any" } }, { "code": "Eu10300", "description": "[X]Mental and behav dis due to use alcohol: withdrawal state", "attributes": { "type": "any" } }, { "code": "Eu10400", "description": "[X]Men & behav dis due alcohl: withdrawl state with delirium", "attributes": { "type": "any" } }, { "code": "Eu10411", "description": "[X]Delirium tremens, alcohol induced", "attributes": { "type": "any" } }, { 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1, "doi": "https://doi.org/10.48533/1s1h-7r90", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. 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