[ { "phenotype_id": "PH4104", "phenotype_version_id": 9322, "name": "Anxiety disorders", "definition": "A cognitive disorder that involves an excessive, irrational dread of everyday situations.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:05:58.123876Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:05:58.118241Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Anxiety disorder (disorder)", "value": 773972 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "UKBioBank codes", "value": 12 }, { "name": "Non-standard codes", "value": 13 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 9632, "concept_version_id": 17117, "concept_name": "Mental health problems ever diagnosed by a professional", "coding_system": { "id": 13, "name": "Non-standard codes", "description": "Non-standard codes" }, "phenotype_id": "PH4104", "phenotype_version_id": 9322, "phenotype_name": "Anxiety disorders", "code_attribute_header": [ "type" ], "codes": [ { "code": "15", "description": "Anxiety, nerves or generalized anxiety disorder", "attributes": { "type": "any" } } ] }, { "concept_id": 9633, "concept_version_id": 17118, "concept_name": "Professional informed about anxiety", "coding_system": { "id": 13, "name": "Non-standard codes", "description": "Non-standard codes" }, "phenotype_id": "PH4104", "phenotype_version_id": 9322, "phenotype_name": "Anxiety disorders", "code_attribute_header": [ "type" ], "codes": [ { "code": "1", "description": "yes", "attributes": { "type": "any" } } ] }, { "concept_id": 9634, "concept_version_id": 17119, "concept_name": "Ever been offered/sought treatment for anxiety", "coding_system": { "id": 13, "name": "Non-standard codes", "description": "Non-standard codes" }, "phenotype_id": "PH4104", "phenotype_version_id": 9322, "phenotype_name": "Anxiety disorders", "code_attribute_header": [ "type" ], "codes": [ { "code": "1", "description": "yes", "attributes": { "type": "any" } } ] }, { "concept_id": 9635, "concept_version_id": 17120, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4104", "phenotype_version_id": 9322, "phenotype_name": "Anxiety disorders", "code_attribute_header": [ "type" ], "codes": [ { "code": "1287", "description": "anxiety/panic attacks", "attributes": { "type": "any" } } ] }, { "concept_id": 9636, "concept_version_id": 17121, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4104", "phenotype_version_id": 9322, "phenotype_name": "Anxiety disorders", "code_attribute_header": [ "type" ], "codes": [ { "code": "F40", "description": "Phobic anxiety disorders", "attributes": { "type": "any" } }, { "code": "F41", "description": "Other anxiety disorders", "attributes": { "type": "any" } } ] }, { "concept_id": 9637, "concept_version_id": 17122, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4104", "phenotype_version_id": 9322, "phenotype_name": "Anxiety disorders", "code_attribute_header": [ "type" ], "codes": [ { "code": "F40", "description": "Phobic anxiety disorders", "attributes": { "type": "any" } }, { "code": "F41", "description": "Other anxiety disorders", "attributes": { "type": "any" } } ] }, { "concept_id": 9638, "concept_version_id": 17123, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4104", "phenotype_version_id": 9322, "phenotype_name": "Anxiety disorders", "code_attribute_header": [ "type" ], "codes": [ { "code": "F40", "description": "Phobic anxiety disorders", "attributes": { "type": "any" } }, { "code": "F41", "description": "Other anxiety disorders", "attributes": { "type": "any" } } ] }, { "concept_id": 9639, "concept_version_id": 17124, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4104", "phenotype_version_id": 9322, "phenotype_name": "Anxiety disorders", "code_attribute_header": [ "type" ], "codes": [ { "code": "F40", "description": "Phobic anxiety disorders", "attributes": { "type": "any" } }, { "code": "F41", "description": "Other anxiety disorders", "attributes": { "type": "any" } } ] }, { "concept_id": 9640, "concept_version_id": 17125, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4104", "phenotype_version_id": 9322, "phenotype_name": "Anxiety disorders", "code_attribute_header": [ "type" ], "codes": [ { "code": "1466.00", "description": "H/O: anxiety state", "attributes": { "type": "prevalent" } }, { "code": "146G.00", "description": "H/O: agoraphobia", "attributes": { "type": "prevalent" } }, { "code": "1B1H.11", "description": "Fear", "attributes": { "type": "any" } }, { "code": "1B1V.00", "description": "C/O - panic attack", "attributes": { "type": "any" } }, { "code": "1Bb..00", "description": "Specific fear", "attributes": { "type": "any" } }, { "code": "225J.00", "description": "O/E - panic attack", "attributes": { "type": "any" } }, { "code": "225K.00", "description": "O/E - fearful mood", "attributes": { "type": "any" } }, { "code": "285..00", "description": "Neurotic condition, insight present", "attributes": { "type": "any" } }, { "code": "286..00", "description": "Poor insight into neurotic condition", "attributes": { "type": "any" } }, { "code": "8G52.00", "description": "Antiphobic therapy", "attributes": { "type": "any" } }, { "code": "8G94.00", "description": "Anxiety management training", "attributes": { "type": "any" } }, { "code": "8HHp.00", "description": "Referral for guided self-help for anxiety", "attributes": { "type": "any" } }, { "code": "9N54.00", "description": "Encounter for fear", "attributes": { "type": "any" } }, { "code": "E20..00", "description": "Neurotic disorders", "attributes": { "type": "any" } }, { "code": "E200.00", "description": "Anxiety states", "attributes": { "type": "any" } }, { "code": "E200000", "description": "Anxiety state unspecified", "attributes": { "type": "any" } }, { "code": "E200100", "description": "Panic disorder", "attributes": { "type": "any" } }, { "code": "E200111", "description": "Panic attack", "attributes": { "type": "any" } }, { "code": "E200200", "description": "Generalised anxiety disorder", "attributes": { "type": "any" } }, { "code": "E200300", "description": "Anxiety with depression", "attributes": { "type": "any" } }, { "code": "E200400", "description": "Chronic anxiety", "attributes": { "type": "any" } }, { "code": "E200500", "description": "Recurrent anxiety", "attributes": { "type": "any" } }, { "code": "E200z00", "description": "Anxiety state NOS", "attributes": { "type": "any" } }, { "code": "E201B00", "description": "Compensation neurosis", "attributes": { "type": "any" } }, { "code": "E202.00", "description": "Phobic disorders", "attributes": { "type": "any" } }, { "code": "E202000", "description": "Phobia unspecified", "attributes": { "type": "any" } }, { "code": "E202100", "description": "Agoraphobia with panic attacks", "attributes": { "type": "any" } }, { "code": "E202.11", "description": "Social phobic disorders", "attributes": { "type": "any" } }, { "code": "E202.12", "description": "Phobic anxiety", "attributes": { "type": "any" } }, { "code": "E202200", "description": "Agoraphobia without mention of panic attacks", "attributes": { "type": "any" } }, { "code": "E202300", "description": "Social phobia, fear of eating in public", "attributes": { "type": "any" } }, { "code": "E202400", "description": "Social phobia, fear of public speaking", "attributes": { "type": "any" } }, { "code": "E202500", "description": "Social phobia, fear of public washing", "attributes": { "type": "any" } }, { "code": "E202600", "description": "Acrophobia", "attributes": { "type": "any" } }, { "code": "E202700", "description": "Animal phobia", "attributes": { "type": "any" } }, { "code": "E202800", "description": "Claustrophobia", "attributes": { "type": "any" } }, { "code": "E202900", "description": "Fear of crowds", "attributes": { "type": "any" } }, { "code": "E202A00", "description": "Fear of flying", "attributes": { "type": "any" } }, { "code": "E202B00", "description": "Cancer phobia", "attributes": { "type": "any" } }, { "code": "E202C00", "description": "Dental phobia", "attributes": { "type": "any" } }, { "code": "E202D00", "description": "Fear of death", "attributes": { "type": "any" } }, { "code": "E202E00", "description": "Fear of pregnancy", "attributes": { "type": "any" } }, { "code": "E202z00", "description": "Phobic disorder NOS", "attributes": { "type": "any" } }, { "code": "E20y.00", "description": "Other neurotic disorders", "attributes": { "type": "any" } }, { "code": "E20y100", "description": "Writer's cramp neurosis", "attributes": { "type": "any" } }, { "code": "E20y200", "description": "Other occupational neurosis", "attributes": { "type": "any" } }, { "code": "E20y300", "description": "Psychasthenic neurosis", "attributes": { "type": "any" } }, { "code": "E20yz00", "description": "Other neurotic disorder NOS", "attributes": { "type": "any" } }, { "code": "E20z.00", "description": "Neurotic disorder NOS", "attributes": { "type": "any" } }, { "code": "Eu34111", "description": "[X]Depressive neurosis", "attributes": { "type": "any" } }, { "code": "Eu34113", "description": "[X]Neurotic depression", "attributes": { "type": "any" } }, { "code": "Eu34114", "description": "[X]Persistant anxiety depression", "attributes": { "type": "any" } }, { "code": "Eu40.00", "description": "[X]Phobic anxiety disorders", "attributes": { "type": "any" } }, { "code": "Eu40000", "description": "[X]Agoraphobia", "attributes": { "type": "any" } }, { "code": "Eu40011", "description": "[X]Agoraphobia without history of panic disorder", "attributes": { "type": "any" } }, { "code": "Eu40012", "description": "[X]Panic disorder with agoraphobia", "attributes": { "type": "any" } }, { "code": "Eu40100", "description": "[X]Social phobias", "attributes": { "type": "any" } }, { "code": "Eu40112", "description": "[X]Social neurosis", "attributes": { "type": "any" } }, { "code": "Eu40200", "description": "[X]Specific (isolated) phobias", "attributes": { "type": "any" } }, { "code": "Eu40211", "description": "[X]Acrophobia", "attributes": { "type": "any" } }, { "code": "Eu40212", "description": "[X]Animal phobias", "attributes": { "type": "any" } }, { "code": "Eu40213", "description": "[X]Claustrophobia", "attributes": { "type": "any" } }, { "code": "Eu40214", "description": "[X]Simple phobia", "attributes": { "type": "any" } }, { "code": "Eu40300", "description": "[X]Needle phobia", "attributes": { "type": "any" } }, { "code": "Eu40y00", "description": "[X]Other phobic anxiety disorders", "attributes": { "type": "any" } }, { "code": "Eu40z00", "description": "[X]Phobic anxiety disorder, unspecified", "attributes": { "type": "any" } }, { "code": "Eu40z11", "description": "[X]Phobia NOS", "attributes": { "type": "any" } }, { "code": "Eu40z12", "description": "[X]Phobic state NOS", "attributes": { "type": "any" } }, { "code": "Eu41.00", "description": "[X]Other anxiety disorders", "attributes": { "type": "any" } }, { "code": "Eu41000", "description": "[X]Panic disorder [episodic paroxysmal anxiety]", "attributes": { "type": "any" } }, { "code": "Eu41011", "description": "[X]Panic attack", "attributes": { "type": "any" } }, { "code": "Eu41012", "description": "[X]Panic state", "attributes": { "type": "any" } }, { "code": "Eu41100", "description": "[X]Generalized anxiety disorder", "attributes": { "type": "any" } }, { "code": "Eu41111", "description": "[X]Anxiety neurosis", "attributes": { "type": "any" } }, { "code": "Eu41112", "description": "[X]Anxiety reaction", "attributes": { "type": "any" } }, { "code": "Eu41113", "description": "[X]Anxiety state", "attributes": { "type": "any" } }, { "code": "Eu41200", "description": "[X]Mixed anxiety and depressive disorder", "attributes": { "type": "any" } }, { "code": "Eu41211", "description": "[X]Mild anxiety depression", "attributes": { "type": "any" } }, { "code": "Eu41300", "description": "[X]Other mixed anxiety disorders", "attributes": { "type": "any" } }, { "code": "Eu41y00", "description": "[X]Other specified anxiety disorders", "attributes": { "type": "any" } }, { "code": "Eu41y11", "description": "[X]Anxiety hysteria", "attributes": { "type": "any" } }, { "code": "Eu41z00", "description": "[X]Anxiety disorder, unspecified", "attributes": { "type": "any" } }, { "code": "Eu41z11", "description": "[X]Anxiety NOS", "attributes": { "type": "any" } }, { "code": "Ub0qs", "description": "Anxiety management training", "attributes": { "type": "any" } }, { "code": "X7627", "description": "Specific fear", "attributes": { "type": "any" } }, { "code": "X762G", "description": "Fear of flying", "attributes": { "type": "any" } }, { "code": "X762T", "description": "Fear of death", "attributes": { "type": "any" } }, { "code": "Xa7lj", "description": "Cancer phobia", "attributes": { "type": "any" } }, { "code": "XaIo7", "description": "C/O - panic attack", "attributes": { "type": "any" } }, { "code": "XaK2c", "description": "H/O: agoraphobia", "attributes": { "type": "prevalent" } }, { "code": "XaKVA", "description": "O/E - panic attack", "attributes": { "type": "any" } }, { "code": "XaKVN", "description": "O/E - fearful mood", "attributes": { "type": "any" } }, { "code": "XaL0q", "description": "Referral for guided self-help for anxiety", "attributes": { "type": "any" } }, { "code": "XE1hk", "description": "Neurotic condition, insight present", "attributes": { "type": "any" } }, { "code": "XE1hl", "description": "Poor insight into neurotic condition", "attributes": { "type": "any" } }, { "code": "XE1Y7", "description": "Panic disorder", "attributes": { "type": "any" } }, { "code": "XE1YB", "description": "Phobic disorder NOS", "attributes": { "type": "any" } }, { "code": "XE1YE", "description": "Neurotic disorder NOS", "attributes": { "type": "any" } }, { "code": "XE1Zj", "description": "[X]Other specified anxiety disorders", "attributes": { "type": "any" } }, { "code": "Z481.00", "description": "Phobia counselling", "attributes": { "type": "any" } }, { "code": "Z4L1.00", "description": "Anxiety counselling", "attributes": { "type": "any" } }, { "code": "ZV11200", "description": "[V]Personal history of neurosis", "attributes": { "type": "prevalent" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/1pc0-6d32", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9322, "version_name": "Anxiety disorders", "version_date": "2026-06-08T20:05:58.131570Z", "is_published": true, "is_latest": true } ] } ]