[
  {
    "phenotype_id": "PH4132",
    "phenotype_version_id": 9350,
    "name": "Carpal tunnel syndrome",
    "definition": "Carpal tunnel syndrome (CTS) occurs when the median nerve, which runs from the forearm into the palm of the hand, becomes pressed or squeezed at the wrist.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:07:25.310466Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:07:25.304901Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Carpal tunnel syndrome (disorder)",
        "value": 13007
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      },
      {
        "name": "OPCS4 codes",
        "value": 7
      },
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "Non-standard codes",
        "value": 13
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 9805,
        "concept_version_id": 17290,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4132",
        "phenotype_version_id": 9350,
        "phenotype_name": "Carpal tunnel syndrome",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1541",
            "description": "carpal tunnel syndrome",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9806,
        "concept_version_id": 17291,
        "concept_name": "Operation code",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4132",
        "phenotype_version_id": 9350,
        "phenotype_name": "Carpal tunnel syndrome",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1501",
            "description": "carpal tunnel surgery",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9807,
        "concept_version_id": 17292,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4132",
        "phenotype_version_id": 9350,
        "phenotype_name": "Carpal tunnel syndrome",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "G56.0",
            "description": "Carpal tunnel syndrome",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9808,
        "concept_version_id": 17293,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4132",
        "phenotype_version_id": 9350,
        "phenotype_name": "Carpal tunnel syndrome",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "G56.0",
            "description": "Carpal tunnel syndrome",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9809,
        "concept_version_id": 17294,
        "concept_name": "Operative procedures - main OPCS4",
        "coding_system": {
          "id": 7,
          "name": "OPCS4 codes",
          "description": "OPCS4 codes"
        },
        "phenotype_id": "PH4132",
        "phenotype_version_id": 9350,
        "phenotype_name": "Carpal tunnel syndrome",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "A65.1",
            "description": "Carpal tunnel release",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A69.2",
            "description": "Revision of carpal tunnel release",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9810,
        "concept_version_id": 17295,
        "concept_name": "Operative procedures - secondary OPCS4",
        "coding_system": {
          "id": 7,
          "name": "OPCS4 codes",
          "description": "OPCS4 codes"
        },
        "phenotype_id": "PH4132",
        "phenotype_version_id": 9350,
        "phenotype_name": "Carpal tunnel syndrome",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "A65.1",
            "description": "A65.1",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A69.2",
            "description": "A69.2",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9811,
        "concept_version_id": 17296,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4132",
        "phenotype_version_id": 9350,
        "phenotype_name": "Carpal tunnel syndrome",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "G56.0",
            "description": "Carpal tunnel syndrome",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9812,
        "concept_version_id": 17297,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4132",
        "phenotype_version_id": 9350,
        "phenotype_name": "Carpal tunnel syndrome",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "G56.0",
            "description": "Carpal tunnel syndrome",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9813,
        "concept_version_id": 17298,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4132",
        "phenotype_version_id": 9350,
        "phenotype_name": "Carpal tunnel syndrome",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "7056000.0",
            "description": "Carpal tunnel release",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7056011.0",
            "description": "Carpal tunnel decompression",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7056200.0",
            "description": "Re-release of carpal tunnel",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7056400.0",
            "description": "Endoscopic carpal tunnel release",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "705A100",
            "description": "Revision of carpal tunnel release",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "85BE.00",
            "description": "Injection of carpal tunnel",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "8Hlr.00",
            "description": "Referral for carpal tunnel injection",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "9Nu3000",
            "description": "Consent given for carpal tunnel injection",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F340.00",
            "description": "Carpal tunnel syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F340.12",
            "description": "CTS - Carpal tunnel syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaZbY",
            "description": "Consent given for carpal tunnel injection",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaZhO",
            "description": "Referral for carpal tunnel injection",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE15g",
            "description": "Carpal tunnel syndrome",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9814,
        "concept_version_id": 17299,
        "concept_name": "Ever had carpal tunnel syndrome",
        "coding_system": {
          "id": 13,
          "name": "Non-standard codes",
          "description": "Non-standard codes"
        },
        "phenotype_id": "PH4132",
        "phenotype_version_id": 9350,
        "phenotype_name": "Carpal tunnel syndrome",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1",
            "description": "yes",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/s064-4510",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9350,
        "version_name": "Carpal tunnel syndrome",
        "version_date": "2026-06-08T20:07:25.319932Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]