[ { "phenotype_id": "PH4136", "phenotype_version_id": 9354, "name": "Coronary heart disease not otherwise specified", "definition": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:07:38.372991Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:07:38.367460Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Coronary arteriosclerosis (disorder)", "value": 548841 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 9836, "concept_version_id": 17321, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4136", "phenotype_version_id": 9354, "phenotype_name": "Coronary heart disease not otherwise specified", "code_attribute_header": [ "type" ], "codes": [ { "code": "1066", "description": "heart/cardiac problem", "attributes": { "type": "any" } } ] }, { "concept_id": 9837, "concept_version_id": 17322, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4136", "phenotype_version_id": 9354, "phenotype_name": "Coronary heart disease not otherwise specified", "code_attribute_header": [ "type" ], "codes": [ { "code": "I25.0", "description": "Atherosclerotic cardiovascular disease, so described", "attributes": { "type": "any" } }, { "code": "I25.1", "description": "Atherosclerotic heart disease", "attributes": { "type": "any" } }, { "code": "I25.3", "description": "Aneurysm of heart", "attributes": { "type": "any" } }, { "code": "I25.4", "description": "Coronary artery aneurysm", "attributes": { "type": "any" } }, { "code": "I25.5", "description": "Ischaemic cardiomyopathy", "attributes": { "type": "any" } }, { "code": "I25.6", "description": "Silent myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "I25.8", "description": "Other forms of chronic ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "I25.9", "description": "Chronic ischaemic heart disease, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 9838, "concept_version_id": 17323, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4136", "phenotype_version_id": 9354, "phenotype_name": "Coronary heart disease not otherwise specified", "code_attribute_header": [ "type" ], "codes": [ { "code": "I25.0", "description": "Atherosclerotic cardiovascular disease, so described", "attributes": { "type": "any" } }, { "code": "I25.1", "description": "Atherosclerotic heart disease", "attributes": { "type": "any" } }, { "code": "I25.3", "description": "Aneurysm of heart", "attributes": { "type": "any" } }, { "code": "I25.4", "description": "Coronary artery aneurysm", "attributes": { "type": "any" } }, { "code": "I25.5", "description": "Ischaemic cardiomyopathy", "attributes": { "type": "any" } }, { "code": "I25.6", "description": "Silent myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "I25.8", "description": "Other forms of chronic ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "I25.9", "description": "Chronic ischaemic heart disease, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 9839, "concept_version_id": 17324, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4136", "phenotype_version_id": 9354, "phenotype_name": "Coronary heart disease not otherwise specified", "code_attribute_header": [ "type" ], "codes": [ { "code": "I25.0", "description": "Atherosclerotic cardiovascular disease, so described", "attributes": { "type": "any" } }, { "code": "I25.1", "description": "Atherosclerotic heart disease", "attributes": { "type": "any" } }, { "code": "I25.3", "description": "Aneurysm of heart", "attributes": { "type": "any" } }, { "code": "I25.4", "description": "Coronary artery aneurysm", "attributes": { "type": "any" } }, { "code": "I25.5", "description": "Ischaemic cardiomyopathy", "attributes": { "type": "any" } }, { "code": "I25.6", "description": "Silent myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "I25.8", "description": "Other forms of chronic ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "I25.9", "description": "Chronic ischaemic heart disease, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 9840, "concept_version_id": 17325, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4136", "phenotype_version_id": 9354, "phenotype_name": "Coronary heart disease not otherwise specified", "code_attribute_header": [ "type" ], "codes": [ { "code": "I25.0", "description": "Atherosclerotic cardiovascular disease, so described", "attributes": { "type": "any" } }, { "code": "I25.1", "description": "Atherosclerotic heart disease", "attributes": { "type": "any" } }, { "code": "I25.3", "description": "Aneurysm of heart", "attributes": { "type": "any" } }, { "code": "I25.4", "description": "Coronary artery aneurysm", "attributes": { "type": "any" } }, { "code": "I25.5", "description": "Ischaemic cardiomyopathy", "attributes": { "type": "any" } }, { "code": "I25.6", "description": "Silent myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "I25.8", "description": "Other forms of chronic ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "I25.9", "description": "Chronic ischaemic heart disease, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 9841, "concept_version_id": 17326, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4136", "phenotype_version_id": 9354, "phenotype_name": "Coronary heart disease not otherwise specified", "code_attribute_header": [ "type" ], "codes": [ { "code": "14AL.00", "description": "H/O: Treatment for ischaemic heart disease", "attributes": { "type": "prevalent" } }, { "code": "6A2..00", "description": "Coronary heart disease annual review", "attributes": { "type": "prevalent" } }, { "code": "6A4..00", "description": "Coronary heart disease review", "attributes": { "type": "prevalent" } }, { "code": "8B3k.00", "description": "Coronary heart disease medication review", "attributes": { "type": "prevalent" } }, { "code": "8H2V.00", "description": "Admit ischaemic heart disease emergency", "attributes": { "type": "any" } }, { "code": "G3...00", "description": "Ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "G31..", "description": "Other acute and subacute ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "G31..00", "description": "Other acute and subacute ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "G3...11", "description": "Arteriosclerotic heart disease", "attributes": { "type": "any" } }, { "code": "G311000", "description": "Myocardial infarction aborted", "attributes": { "type": "any" } }, { "code": "G311011", "description": "MI - myocardial infarction aborted", "attributes": { "type": "any" } }, { "code": "G3...12", "description": "Atherosclerotic heart disease", "attributes": { "type": "any" } }, { "code": "G3...13", "description": "IHD - Ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "G31y.00", "description": "Other acute and subacute ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "G31y200", "description": "Subendocardial ischaemia", "attributes": { "type": "any" } }, { "code": "G31y300", "description": "Transient myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "G31yz00", "description": "Other acute and subacute ischaemic heart disease NOS", "attributes": { "type": "any" } }, { "code": "G34..00", "description": "Other chronic ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "G340.00", "description": "Coronary atherosclerosis", "attributes": { "type": "any" } }, { "code": "G340.12", "description": "Coronary artery disease", "attributes": { "type": "any" } }, { "code": "G343.00", "description": "Ischaemic cardiomyopathy", "attributes": { "type": "any" } }, { "code": "G344.00", "description": "Silent myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "G34y.00", "description": "Other specified chronic ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "G34y100", "description": "Chronic myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "G34yz00", "description": "Other specified chronic ischaemic heart disease NOS", "attributes": { "type": "any" } }, { "code": "G34z.00", "description": "Other chronic ischaemic heart disease NOS", "attributes": { "type": "any" } }, { "code": "G34z000", "description": "Asymptomatic coronary heart disease", "attributes": { "type": "any" } }, { "code": "G3y..00", "description": "Other specified ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "G3z..00", "description": "Ischaemic heart disease NOS", "attributes": { "type": "any" } }, { "code": "Gyu3.00", "description": "[X]Ischaemic heart diseases", "attributes": { "type": "any" } }, { "code": "Gyu3200", "description": "[X]Other forms of acute ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "Gyu3300", "description": "[X]Other forms of chronic ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "X200D", "description": "Silent myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "XaBL4", "description": "H/O: Treatment for ischaemic heart disease", "attributes": { "type": "prevalent" } }, { "code": "XaFsH", "description": "Transient myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "XaG1Q", "description": "Asymptomatic coronary heart disease", "attributes": { "type": "any" } }, { "code": "XaI9h", "description": "Coronary heart disease annual review", "attributes": { "type": "prevalent" } }, { "code": "XaIfL", "description": "Coronary heart disease medication review", "attributes": { "type": "prevalent" } }, { "code": "XaIOW", "description": "Coronary heart disease review", "attributes": { "type": "prevalent" } }, { "code": "XaNxN", "description": "Admit ischaemic heart disease emergency", "attributes": { "type": "any" } }, { "code": "XE2uV", "description": "Ischaemic heart disease", "attributes": { "type": "any" } }, { "code": "XM0rN", "description": "Coronary atherosclerosis", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/y1ps-m619", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9354, "version_name": "Coronary heart disease not otherwise specified", "version_date": "2026-06-08T20:07:38.383508Z", "is_published": true, "is_latest": true } ] } ]