[
  {
    "phenotype_id": "PH4140",
    "phenotype_version_id": 9358,
    "name": "Postviral fatigue syndrome, neurasthenia and fibromyalgia",
    "definition": "Chronic fatigue syndrome (CFS) is a complicated disorder characterized by extreme fatigue that lasts for at least six months and that can't be fully explained by an underlying medical condition.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:07:50.154344Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:07:50.146399Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Postviral fatigue syndrome (disorder)",
        "value": 298922
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "Non-standard codes",
        "value": 13
      },
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 9863,
        "concept_version_id": 17348,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4140",
        "phenotype_version_id": 9358,
        "phenotype_name": "Postviral fatigue syndrome, neurasthenia and fibromyalgia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1482",
            "description": "chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "1542",
            "description": "fibromyalgia",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9864,
        "concept_version_id": 17349,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4140",
        "phenotype_version_id": 9358,
        "phenotype_name": "Postviral fatigue syndrome, neurasthenia and fibromyalgia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "F48.0",
            "description": "Neurasthenia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G93.3",
            "description": "Postviral fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "M79.7",
            "description": "Fibromyalgia",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9865,
        "concept_version_id": 17350,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4140",
        "phenotype_version_id": 9358,
        "phenotype_name": "Postviral fatigue syndrome, neurasthenia and fibromyalgia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "F48.0",
            "description": "Neurasthenia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G93.3",
            "description": "Postviral fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "M79.7",
            "description": "Fibromyalgia",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9866,
        "concept_version_id": 17351,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4140",
        "phenotype_version_id": 9358,
        "phenotype_name": "Postviral fatigue syndrome, neurasthenia and fibromyalgia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "F48.0",
            "description": "Neurasthenia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G93.3",
            "description": "Postviral fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "M79.7",
            "description": "Fibromyalgia",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9867,
        "concept_version_id": 17352,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4140",
        "phenotype_version_id": 9358,
        "phenotype_name": "Postviral fatigue syndrome, neurasthenia and fibromyalgia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "F48.0",
            "description": "Neurasthenia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G93.3",
            "description": "Postviral fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "M79.7",
            "description": "Fibromyalgia",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9868,
        "concept_version_id": 17353,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4140",
        "phenotype_version_id": 9358,
        "phenotype_name": "Postviral fatigue syndrome, neurasthenia and fibromyalgia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "8HlL.00",
            "description": "Referral for chronic fatigue syndrome activity management",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "8HlL.11",
            "description": "Referral for myalgic encephalopathy activity management",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "8Q1..00",
            "description": "Activity management for chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "8Q1..11",
            "description": "Activity management for myalgic encephalopathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E205.00",
            "description": "Neurasthenia - nervous debility",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu46000",
            "description": "[X]Neurasthenia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu46011",
            "description": "[X]Fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F03y.12",
            "description": "Myalgic encephalomyelitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F286.00",
            "description": "Chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F286000",
            "description": "Mild chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F286100",
            "description": "Moderate chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F286.11",
            "description": "CFS - Chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F286.12",
            "description": "Postviral fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F286.13",
            "description": "PVFS - Postviral fatigue syn",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F286.14",
            "description": "Post-viral fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F286.15",
            "description": "Myalgic encephalomyelitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F286.16",
            "description": "ME - Myalgic encephalomyelitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F286200",
            "description": "Severe chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N239.00",
            "description": "Fibromyalgia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N240100",
            "description": "Fibrositis unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N240500",
            "description": "Fibrositis of neck",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N240600",
            "description": "Fibrositis arm",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N248.00",
            "description": "Fibromyalgia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "R007400",
            "description": "[D]Postviral (asthenic) syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "R007411",
            "description": "[D]Post viral debility",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "X75rx",
            "description": "Fibromyalgia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Xa01F",
            "description": "Chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaPeC",
            "description": "Activity management for chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaPom",
            "description": "Mild chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaPon",
            "description": "Moderate chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaPoo",
            "description": "Severe chronic fatigue syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaRAz",
            "description": "Referral for chronic fatigue syndrome activity management",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE15C",
            "description": "Other causes of encephalitis",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9869,
        "concept_version_id": 17354,
        "concept_name": "Ever had chronic Fatigue Syndrome or Myalgic Encephalomyelitis (M.E.)",
        "coding_system": {
          "id": 13,
          "name": "Non-standard codes",
          "description": "Non-standard codes"
        },
        "phenotype_id": "PH4140",
        "phenotype_version_id": 9358,
        "phenotype_name": "Postviral fatigue syndrome, neurasthenia and fibromyalgia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1",
            "description": "yes",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9870,
        "concept_version_id": 17355,
        "concept_name": "Ever had fibromyalgia",
        "coding_system": {
          "id": 13,
          "name": "Non-standard codes",
          "description": "Non-standard codes"
        },
        "phenotype_id": "PH4140",
        "phenotype_version_id": 9358,
        "phenotype_name": "Postviral fatigue syndrome, neurasthenia and fibromyalgia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1",
            "description": "yes",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/py1f-r345",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9358,
        "version_name": "Postviral fatigue syndrome, neurasthenia and fibromyalgia",
        "version_date": "2026-06-08T20:07:50.167563Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]