[ { "phenotype_id": "PH4142", "phenotype_version_id": 9360, "name": "Chronic viral hepatitis", "definition": "Viral hepatitis is liver inflammation due to a viral infection.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:07:55.834340Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:07:55.828109Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": null, "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 9876, "concept_version_id": 17361, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4142", "phenotype_version_id": 9360, "phenotype_name": "Chronic viral hepatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "1581", "description": "hepatitis d", "attributes": { "type": "any" } } ] }, { "concept_id": 9877, "concept_version_id": 17362, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4142", "phenotype_version_id": 9360, "phenotype_name": "Chronic viral hepatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "B18", "description": "Chronic viral hepatitis", "attributes": { "type": "any" } } ] }, { "concept_id": 9878, "concept_version_id": 17363, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4142", "phenotype_version_id": 9360, "phenotype_name": "Chronic viral hepatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "B18", "description": "Chronic viral hepatitis", "attributes": { "type": "any" } } ] }, { "concept_id": 9879, "concept_version_id": 17364, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4142", "phenotype_version_id": 9360, "phenotype_name": "Chronic viral hepatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "B18", "description": "Chronic viral hepatitis", "attributes": { "type": "any" } } ] }, { "concept_id": 9880, "concept_version_id": 17365, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4142", "phenotype_version_id": 9360, "phenotype_name": "Chronic viral hepatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "B18", "description": "Chronic viral hepatitis", "attributes": { "type": "any" } } ] }, { "concept_id": 9881, "concept_version_id": 17366, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4142", "phenotype_version_id": 9360, "phenotype_name": "Chronic viral hepatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "141E.00", "description": "History of hepatitis B", "attributes": { "type": "prevalent" } }, { "code": "14i..00", "description": "H/O hepatitis C antiviral drug therapy", "attributes": { "type": "prevalent" } }, { "code": "2126700.0", "description": "Hepatitis C resolved", "attributes": { "type": "any" } }, { "code": "43B4.00", "description": "Hepatitis B surface antig +ve", "attributes": { "type": "any" } }, { "code": "43B5.00", "description": "Hepatitis e antigen present", "attributes": { "type": "any" } }, { "code": "43j5.00", "description": "Hepatitis C nucleic acid detection", "attributes": { "type": "any" } }, { "code": "43jG.00", "description": "Hepatitis B nucleic acid detection", "attributes": { "type": "any" } }, { "code": "43X3.00", "description": "Hepatitis C antibody test positive", "attributes": { "type": "any" } }, { "code": "4J3B.00", "description": "Hepatitis C viral load", "attributes": { "type": "any" } }, { "code": "4J3D.00", "description": "Hepatitis B viral load", "attributes": { "type": "any" } }, { "code": "4JQ3.00", "description": "Hepatitis C virus genotype", "attributes": { "type": "any" } }, { "code": "4JQD.00", "description": "Hepatitis C viral ribonucleic acid PCR positive", "attributes": { "type": "any" } }, { "code": "4JQD.11", "description": "Hepatitis C PCR positive", "attributes": { "type": "any" } }, { "code": "4JQF.00", "description": "Hepatitis C antigen positive", "attributes": { "type": "any" } }, { "code": "7Q05200", "description": "Hepatitis B treatment drugs Band 1", "attributes": { "type": "any" } }, { "code": "8BB5.00", "description": "12 week virologic response to hepatitis C treatment", "attributes": { "type": "any" } }, { "code": "9kR..00", "description": "Chronic hepatitis annual review - enhanced services admin", "attributes": { "type": "prevalent" } }, { "code": "9kV..00", "description": "Hepatitis C screening positive - enhanced services admin", "attributes": { "type": "any" } }, { "code": "9kV..11", "description": "Hepatitis C screening positive", "attributes": { "type": "any" } }, { "code": "9kX..00", "description": "Hepatitis status 6 months post treatment - enhanced serv adm", "attributes": { "type": "any" } }, { "code": "9kZ..00", "description": "Hepatitis B screening positive - enhanced services admin", "attributes": { "type": "any" } }, { "code": "9kZ..11", "description": "Hepatitis B screening positive", "attributes": { "type": "any" } }, { "code": "9NgR.00", "description": "On hepatitis C treatment plan", "attributes": { "type": "any" } }, { "code": "A703.00", "description": "Viral (serum) hepatitis B", "attributes": { "type": "any" } }, { "code": "A705000", "description": "Viral hepatitis C without mention of hepatic coma", "attributes": { "type": "any" } }, { "code": "A705100", "description": "Acute delta-(super)infection of hepatitis B carrier", "attributes": { "type": "any" } }, { "code": "A707.00", "description": "Chronic viral hepatitis", "attributes": { "type": "any" } }, { "code": "A707000", "description": "Chronic viral hepatitis B with delta-agent", "attributes": { "type": "any" } }, { "code": "A707100", "description": "Chronic viral hepatitis B without delta-agent", "attributes": { "type": "any" } }, { "code": "A707200", "description": "Chronic viral hepatitis C", "attributes": { "type": "any" } }, { "code": "A707300", "description": "Chronic viral hepatitis B", "attributes": { "type": "any" } }, { "code": "A707X00", "description": "Chronic viral hepatitis, unspecified", "attributes": { "type": "any" } }, { "code": "A70A.00", "description": "Hepatitis C genotype 1", "attributes": { "type": "any" } }, { "code": "A70B.00", "description": "Hepatitis C genotype 2", "attributes": { "type": "any" } }, { "code": "A70C.00", "description": "Hepatitis C genotype 3", "attributes": { "type": "any" } }, { "code": "A70D.00", "description": "Hepatitis C genotype 4", "attributes": { "type": "any" } }, { "code": "A70z000", "description": "Hepatitis C", "attributes": { "type": "any" } }, { "code": "AyuB100", "description": "[X]Other chronic viral hepatitis", "attributes": { "type": "any" } }, { "code": "AyuB200", "description": "[X]Chronic viral hepatitis, unspecified", "attributes": { "type": "any" } }, { "code": "Q409100", "description": "Congenital hepatitis B infection", "attributes": { "type": "any" } }, { "code": "X306h", "description": "Chronic viral hepatitis", "attributes": { "type": "any" } }, { "code": "X306i", "description": "Chronic viral hepatitis B", "attributes": { "type": "any" } }, { "code": "X306k", "description": "Chronic viral hepatitis C", "attributes": { "type": "any" } }, { "code": "XaFDz", "description": "Hepatitis C antibody test positive", "attributes": { "type": "any" } }, { "code": "XaILY", "description": "Hepatitis C nucleic acid detection", "attributes": { "type": "any" } }, { "code": "XaIrP", "description": "Hepatitis B nucleic acid detection", "attributes": { "type": "any" } }, { "code": "XaIrY", "description": "Hepatitis C viral load", "attributes": { "type": "any" } }, { "code": "XaIrZ", "description": "Hepatitis C virus genotype", "attributes": { "type": "any" } }, { "code": "XaLow", "description": "History of hepatitis B", "attributes": { "type": "prevalent" } }, { "code": "XaMBL", "description": "Hepatitis B viral load", "attributes": { "type": "any" } }, { "code": "XaMEk", "description": "Hepatitis B treatment drugs Band 1", "attributes": { "type": "any" } }, { "code": "XaXBp", "description": "Hepatitis C viral ribonucleic acid polymerase chain reaction positive", "attributes": { "type": "any" } }, { "code": "XaXET", "description": "Hepatitis C resolved", "attributes": { "type": "any" } }, { "code": "XaYbh", "description": "Hepatitis C antigen positive", "attributes": { "type": "any" } }, { "code": "XaZ5P", "description": "Hepatitis C genotype 1", "attributes": { "type": "any" } }, { "code": "XaZ5Q", "description": "Hepatitis C genotype 2", "attributes": { "type": "any" } }, { "code": "XaZ5S", "description": "Hepatitis C genotype 3", "attributes": { "type": "any" } }, { "code": "XaZ5T", "description": "Hepatitis C genotype 4", "attributes": { "type": "any" } }, { "code": "XaZBl", "description": "12 week virologic response to hepatitis C treatment", "attributes": { "type": "any" } }, { "code": "XaZDB", "description": "H/O hepatitis C antiviral drug therapy", "attributes": { "type": "prevalent" } }, { "code": "XaZDE", "description": "On hepatitis C treatment plan", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/m7xx-7g23", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9360, "version_name": "Chronic viral hepatitis", "version_date": "2026-06-08T20:07:55.847086Z", "is_published": true, "is_latest": true } ] } ]