[
  {
    "phenotype_id": "PH4165",
    "phenotype_version_id": 9383,
    "name": "Diabetic neurological complications",
    "definition": "A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:09:14.618569Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:09:14.609374Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Neuropathy due to diabetes mellitus (disorder)",
        "value": 550205
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10032,
        "concept_version_id": 17517,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4165",
        "phenotype_version_id": 9383,
        "phenotype_name": "Diabetic neurological complications",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1468",
            "description": "diabetic neuropathy/ulcers",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10033,
        "concept_version_id": 17518,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4165",
        "phenotype_version_id": 9383,
        "phenotype_name": "Diabetic neurological complications",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E10.4",
            "description": "Insulin-dependent diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E11.4",
            "description": "Non-insulin-dependent diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E12.4",
            "description": "Malnutrition-related diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E13.4",
            "description": "Other specified diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E14.4",
            "description": "Unspecified diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G59.0",
            "description": "Diabetic mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G63.2",
            "description": "Diabetic polyneuropathy",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10034,
        "concept_version_id": 17519,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4165",
        "phenotype_version_id": 9383,
        "phenotype_name": "Diabetic neurological complications",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E10.4",
            "description": "Insulin-dependent diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E11.4",
            "description": "Non-insulin-dependent diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E12.4",
            "description": "Malnutrition-related diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E13.4",
            "description": "Other specified diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E14.4",
            "description": "Unspecified diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G59.0",
            "description": "Diabetic mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G63.2",
            "description": "Diabetic polyneuropathy",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10035,
        "concept_version_id": 17520,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4165",
        "phenotype_version_id": 9383,
        "phenotype_name": "Diabetic neurological complications",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E10.4",
            "description": "Insulin-dependent diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E11.4",
            "description": "Non-insulin-dependent diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E12.4",
            "description": "Malnutrition-related diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E13.4",
            "description": "Other specified diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E14.4",
            "description": "Unspecified diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G59.0",
            "description": "Diabetic mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G63.2",
            "description": "Diabetic polyneuropathy",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10036,
        "concept_version_id": 17521,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4165",
        "phenotype_version_id": 9383,
        "phenotype_name": "Diabetic neurological complications",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E10.4",
            "description": "Insulin-dependent diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E11.4",
            "description": "Non-insulin-dependent diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E12.4",
            "description": "Malnutrition-related diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E13.4",
            "description": "Other specified diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E14.4",
            "description": "Unspecified diabetes mellitus - With neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G59.0",
            "description": "Diabetic mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G63.2",
            "description": "Diabetic polyneuropathy",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10037,
        "concept_version_id": 17522,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4165",
        "phenotype_version_id": 9383,
        "phenotype_name": "Diabetic neurological complications",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C106.00",
            "description": "Diabetes mellitus with neurological manifestation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C106000",
            "description": "Diabetes mellitus, juvenile, + neurological manifestation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C106100",
            "description": "Diabetes mellitus, adult onset, + neurological manifestation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C106.11",
            "description": "Diabetic amyotrophy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C106.12",
            "description": "Diabetes mellitus with neuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C106.13",
            "description": "Diabetes mellitus with polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C106y00",
            "description": "Other specified diabetes mellitus with neurological comps",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C106z00",
            "description": "Diabetes mellitus NOS with neurological manifestation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C108200",
            "description": "Insulin-dependent diabetes mellitus with neurological comps",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C108211",
            "description": "Type I diabetes mellitus with neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C108212",
            "description": "Type 1 diabetes mellitus with neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C108B00",
            "description": "Insulin dependent diabetes mellitus with mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C108B11",
            "description": "Type I diabetes mellitus with mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C108C00",
            "description": "Insulin dependent diabetes mellitus with polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C108J00",
            "description": "Insulin dependent diab mell with neuropathic arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C108J11",
            "description": "Type I diabetes mellitus with neuropathic arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C108J12",
            "description": "Type 1 diabetes mellitus with neuropathic arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109200",
            "description": "Non-insulin-dependent diabetes mellitus with neuro comps",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109211",
            "description": "Type II diabetes mellitus with neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109212",
            "description": "Type 2 diabetes mellitus with neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109A00",
            "description": "Non-insulin dependent diabetes mellitus with mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109A11",
            "description": "Type II diabetes mellitus with mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109B00",
            "description": "Non-insulin dependent diabetes mellitus with polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109B11",
            "description": "Type II diabetes mellitus with polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109B12",
            "description": "Type 2 diabetes mellitus with polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109H00",
            "description": "Non-insulin dependent d m with neuropathic arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109H11",
            "description": "Type II diabetes mellitus with neuropathic arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C109H12",
            "description": "Type 2 diabetes mellitus with neuropathic arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10E200",
            "description": "Type 1 diabetes mellitus with neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10E212",
            "description": "Insulin-dependent diabetes mellitus with neurological comps",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10EB00",
            "description": "Type 1 diabetes mellitus with mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10EC00",
            "description": "Type 1 diabetes mellitus with polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10EC11",
            "description": "Type I diabetes mellitus with polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10EC12",
            "description": "Insulin dependent diabetes mellitus with polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10EJ00",
            "description": "Type 1 diabetes mellitus with neuropathic arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10F200",
            "description": "Type 2 diabetes mellitus with neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10F211",
            "description": "Type II diabetes mellitus with neurological complications",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10FA00",
            "description": "Type 2 diabetes mellitus with mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10FA11",
            "description": "Type II diabetes mellitus with mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10FB00",
            "description": "Type 2 diabetes mellitus with polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10FB11",
            "description": "Type II diabetes mellitus with polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10FH00",
            "description": "Type 2 diabetes mellitus with neuropathic arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C10FH11",
            "description": "Type II diabetes mellitus with neuropathic arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F171100",
            "description": "Autonomic neuropathy due to diabetes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F345000",
            "description": "Diabetic mononeuritis multiplex",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F35z000",
            "description": "Diabetic mononeuritis NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F372.00",
            "description": "Polyneuropathy in diabetes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F372000",
            "description": "Acute painful diabetic neuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F372100",
            "description": "Chronic painful diabetic neuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F372.11",
            "description": "Diabetic polyneuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F372.12",
            "description": "Diabetic neuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F372200",
            "description": "Asymptomatic diabetic neuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F381300",
            "description": "Myasthenic syndrome due to diabetic amyotrophy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F381311",
            "description": "Diabetic amyotrophy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F3y0.00",
            "description": "Diabetic mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "M271100",
            "description": "Neuropathic diabetic ulcer - foot",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "X00Al",
            "description": "Diabetic mononeuropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE10H",
            "description": "Diabetes mellitus with neurological manifestation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE15n",
            "description": "Myasthenic syndrome due to diabetic amyotrophy",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/43p4-zf12",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9383,
        "version_name": "Diabetic neurological complications",
        "version_date": "2026-06-08T20:09:14.630988Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]