[ { "phenotype_id": "PH4169", "phenotype_version_id": 9387, "name": "Anorexia and bulimia nervosa", "definition": "Mental disorders defined by abnormal eating behaviors that negatively affect a person's physical or mental health. Anorexia nervosa: the afflicted individual has an intense fear of gaining weight and restrict food or overexercise to manage this fear. Bulimia nervosa: the afflicted individual eats a lot (binging) then tries to rid themselves of the food (purging).\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:09:26.130422Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:09:26.124608Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Eating disorder (disorder)", "value": 286564 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 10054, "concept_version_id": 17539, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4169", "phenotype_version_id": 9387, "phenotype_name": "Anorexia and bulimia nervosa", "code_attribute_header": [ "type" ], "codes": [ { "code": "1470", "description": "anorexia/bulimia/other eating disorder", "attributes": { "type": "any" } } ] }, { "concept_id": 10055, "concept_version_id": 17540, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4169", "phenotype_version_id": 9387, "phenotype_name": "Anorexia and bulimia nervosa", "code_attribute_header": [ "type" ], "codes": [ { "code": "F50.0", "description": "Anorexia nervosa", "attributes": { "type": "any" } }, { "code": "F50.1", "description": "Atypical anorexia nervosa", "attributes": { "type": "any" } }, { "code": "F50.2", "description": "Bulimia nervosa", "attributes": { "type": "any" } }, { "code": "F50.3", "description": "Atypical bulimia nervosa", "attributes": { "type": "any" } } ] }, { "concept_id": 10056, "concept_version_id": 17541, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4169", "phenotype_version_id": 9387, "phenotype_name": "Anorexia and bulimia nervosa", "code_attribute_header": [ "type" ], "codes": [ { "code": "F50.0", "description": "Anorexia nervosa", "attributes": { "type": "any" } }, { "code": "F50.1", "description": "Atypical anorexia nervosa", "attributes": { "type": "any" } }, { "code": "F50.2", "description": "Bulimia nervosa", "attributes": { "type": "any" } }, { "code": "F50.3", "description": "Atypical bulimia nervosa", "attributes": { "type": "any" } } ] }, { "concept_id": 10057, "concept_version_id": 17542, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4169", "phenotype_version_id": 9387, "phenotype_name": "Anorexia and bulimia nervosa", "code_attribute_header": [ "type" ], "codes": [ { "code": "F50.0", "description": "Anorexia nervosa", "attributes": { "type": "any" } }, { "code": "F50.1", "description": "Atypical anorexia nervosa", "attributes": { "type": "any" } }, { "code": "F50.2", "description": "Bulimia nervosa", "attributes": { "type": "any" } }, { "code": "F50.3", "description": "Atypical bulimia nervosa", "attributes": { "type": "any" } } ] }, { "concept_id": 10058, "concept_version_id": 17543, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4169", "phenotype_version_id": 9387, "phenotype_name": "Anorexia and bulimia nervosa", "code_attribute_header": [ "type" ], "codes": [ { "code": "F50.0", "description": "Anorexia nervosa", "attributes": { "type": "any" } }, { "code": "F50.1", "description": "Atypical anorexia nervosa", "attributes": { "type": "any" } }, { "code": "F50.2", "description": "Bulimia nervosa", "attributes": { "type": "any" } }, { "code": "F50.3", "description": "Atypical bulimia nervosa", "attributes": { "type": "any" } } ] }, { "concept_id": 10059, "concept_version_id": 17544, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4169", "phenotype_version_id": 9387, "phenotype_name": "Anorexia and bulimia nervosa", "code_attribute_header": [ "type" ], "codes": [ { "code": "1467.00", "description": "H/O: anorexia nervosa", "attributes": { "type": "prevalent" } }, { "code": "E271.00", "description": "Anorexia nervosa", "attributes": { "type": "any" } }, { "code": "E275100", "description": "Bulimia (non-organic overeating)", "attributes": { "type": "any" } }, { "code": "Eu50000", "description": "[X]Anorexia nervosa", "attributes": { "type": "any" } }, { "code": "Eu50100", "description": "[X]Atypical anorexia nervosa", "attributes": { "type": "any" } }, { "code": "Eu50200", "description": "[X]Bulimia nervosa", "attributes": { "type": "any" } }, { "code": "Eu50211", "description": "[X]Bulimia NOS", "attributes": { "type": "any" } }, { "code": "Eu50300", "description": "[X]Atypical bulimia nervosa", "attributes": { "type": "any" } }, { "code": "R036011", "description": "[D]Bulimia NOS", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/gpq2-dr75", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9387, "version_name": "Anorexia and bulimia nervosa", "version_date": "2026-06-08T20:09:26.140480Z", "is_published": true, "is_latest": true } ] } ]