[
  {
    "phenotype_id": "PH4184",
    "phenotype_version_id": 9402,
    "name": "Folate deficiency anaemia",
    "definition": "A nutritional deficiency disease that is characterized by a decrease in red blood cells due to lack of folate, has_material_basis in insufficient folic acid in diet, hemolytic anemia, alcoholism, and/or certain medicines.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:10:12.834728Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:10:12.830075Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Megaloblastic anemia due to folate deficiency (disorder)",
        "value": 711020
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10144,
        "concept_version_id": 17629,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4184",
        "phenotype_version_id": 9402,
        "phenotype_name": "Folate deficiency anaemia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "D52",
            "description": "Folate deficiency anaemia",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10145,
        "concept_version_id": 17630,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4184",
        "phenotype_version_id": 9402,
        "phenotype_name": "Folate deficiency anaemia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "D52",
            "description": "Folate deficiency anaemia",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10146,
        "concept_version_id": 17631,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4184",
        "phenotype_version_id": 9402,
        "phenotype_name": "Folate deficiency anaemia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "D52",
            "description": "Folate deficiency anaemia",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10147,
        "concept_version_id": 17632,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4184",
        "phenotype_version_id": 9402,
        "phenotype_name": "Folate deficiency anaemia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "D52",
            "description": "Folate deficiency anaemia",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10148,
        "concept_version_id": 17633,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4184",
        "phenotype_version_id": 9402,
        "phenotype_name": "Folate deficiency anaemia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C262000",
            "description": "Folic acid deficiency",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "D012.00",
            "description": "Folate-deficiency anaemia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "D012100",
            "description": "Folate-deficiency anaemia due to dietary causes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "D012.11",
            "description": "Folic acid deficiency anaemia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "D012111",
            "description": "Goat's milk anaemia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "D012200",
            "description": "Folate-deficiency anaemia, drug induced",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "D012300",
            "description": "Folate-deficiency anaemia due to malabsorption",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "D012400",
            "description": "Folate-deficiency anaemia due to liver disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "D012z00",
            "description": "Folate-deficiency anaemia NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "D013000",
            "description": "Combined B12 and folate deficiency anaemia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Dyu0300",
            "description": "[X]Other folate deficiency anaemias",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/ecnt-ed64",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9402,
        "version_name": "Folate deficiency anaemia",
        "version_date": "2026-06-08T20:10:12.843311Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]