[
  {
    "phenotype_id": "PH4186",
    "phenotype_version_id": 9404,
    "name": "Fracture of wrist",
    "definition": "A break of the part of the radius bone which is close to the wrist.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:10:19.547713Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:10:19.541512Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Fracture at wrist and/or hand level (disorder)",
        "value": 774022
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10157,
        "concept_version_id": 17642,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4186",
        "phenotype_version_id": 9404,
        "phenotype_name": "Fracture of wrist",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1634",
            "description": "fracture forearm / wrist",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "1637",
            "description": "fracture wrist / colles fracture",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10158,
        "concept_version_id": 17643,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4186",
        "phenotype_version_id": 9404,
        "phenotype_name": "Fracture of wrist",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "S52.5",
            "description": "Fracture of lower end of radius",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S52.6",
            "description": "Fracture of lower end of both ulna and radius",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10159,
        "concept_version_id": 17644,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4186",
        "phenotype_version_id": 9404,
        "phenotype_name": "Fracture of wrist",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "S52.5",
            "description": "Fracture of lower end of radius",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S52.6",
            "description": "Fracture of lower end of both ulna and radius",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10160,
        "concept_version_id": 17645,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4186",
        "phenotype_version_id": 9404,
        "phenotype_name": "Fracture of wrist",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "S52.5",
            "description": "Fracture of lower end of radius",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S52.6",
            "description": "Fracture of lower end of both ulna and radius",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10161,
        "concept_version_id": 17646,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4186",
        "phenotype_version_id": 9404,
        "phenotype_name": "Fracture of wrist",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "S52.5",
            "description": "Fracture of lower end of radius",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S52.6",
            "description": "Fracture of lower end of both ulna and radius",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10162,
        "concept_version_id": 17647,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4186",
        "phenotype_version_id": 9404,
        "phenotype_name": "Fracture of wrist",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "7K1LM00",
            "description": "Closed reduction of fracture of wrist",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234.00",
            "description": "Closed fracture of radius and ulna, lower end",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234000",
            "description": "Closed fracture of forearm, lower end, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234100",
            "description": "Closed Colles' fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234.11",
            "description": "Wrist fracture - closed",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234111",
            "description": "Smith's fracture - closed",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234200",
            "description": "Closed fracture of the distal radius, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234300",
            "description": "Closed fracture of ulna, styloid process",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234400",
            "description": "Closed fracture of ulna, lower epiphysis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234500",
            "description": "Closed fracture distal ulna, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234600",
            "description": "Closed fracture radius and ulna, distal",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234700",
            "description": "Closed Smith's fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234800",
            "description": "Closed Galeazzi fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234900",
            "description": "Closed volar Barton's fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234911",
            "description": "Closed volar Barton's fracture-dislocation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234912",
            "description": "Closed volar Barton fracture-subluxation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234A00",
            "description": "Closd dorsal Barton's fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234A11",
            "description": "Closed dorsal Barton's fracture-dislocation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234A12",
            "description": "Closed dorsal Barton fracture-subluxation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234B00",
            "description": "Closed fracture radial styloid",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234C00",
            "description": "Closed fracture distal radius, intra-articular, die-punch",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234D00",
            "description": "Closed fracture distal radius, extra-articular, other type",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234E00",
            "description": "Closed fracture distal radius, intra-articular, other type",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234F00",
            "description": "Closed Barton's fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S234z00",
            "description": "Closed fracture of forearm, lower end, NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235.00",
            "description": "Open fracture of radius and ulna, lower end",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235000",
            "description": "Open fracture of forearm, lower end, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235100",
            "description": "Open Colles' fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235.11",
            "description": "Wrist fracture - open",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235111",
            "description": "Smith's fracture - open",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235200",
            "description": "Open fracture of the distal radius, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235300",
            "description": "Open fracture of ulna, styloid process",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235400",
            "description": "Open fracture of ulna, lower epiphysis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235500",
            "description": "Open fracture distal ulna - other",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235600",
            "description": "Open fracture radius and ulna, distal",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235700",
            "description": "Open Smith's fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235800",
            "description": "Open Galeazzi fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235900",
            "description": "Open volar Barton's fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235B00",
            "description": "Open fracture radial styloid",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235C00",
            "description": "Open fracture distal radius, intra-articular, die-punch",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235D00",
            "description": "Open fracture distal radius, extra-articular other type",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235E00",
            "description": "Open fracture distal radius, intra-articular other type",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235F00",
            "description": "Open Barton's fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S235z00",
            "description": "Open fracture of forearm, lower end, NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S23B.00",
            "description": "Fracture of lower end of radius",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S23C.00",
            "description": "Fracture of lower end of both ulna and radius",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C..00",
            "description": "Fracture-dislocation or subluxation of wrist",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C0.00",
            "description": "Closed fracture dislocation of wrist",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C0000",
            "description": "Closed fracture-dislocation distal radio-ulnar joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C0100",
            "description": "Closed fracture-dislocation radiocarpal joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C1.00",
            "description": "Open fracture dislocation wrist",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C1000",
            "description": "Open fracture-dislocation, distal radio-ulnar joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C1100",
            "description": "Open fracture-dislocation radiocarpal joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C2.00",
            "description": "Closed fracture-subluxation of the wrist",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C2000",
            "description": "Closed fracture-subluxation, distal radio-ulnar jt",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C2100",
            "description": "Closed fracture-subluxation radiocarpal joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C3.00",
            "description": "Open fracture-subluxation of the wrist",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C3000",
            "description": "Open fracture-subluxation, distal radio-ulnar joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "S4C3100",
            "description": "Open fracture-subluxation radiocarpal joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "SC3C000",
            "description": "Sequelae of fracture at wrist and hand level",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaBDD",
            "description": "Open Barton's fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaBDE",
            "description": "Closed Barton's fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1kt",
            "description": "Closed fracture of radius and ulna, lower end",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1ku",
            "description": "Closed Colles' fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1kv",
            "description": "Closed fracture of the distal radius, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1kw",
            "description": "Open fracture of radius and ulna, lower end",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1kx",
            "description": "Open Colles' fracture",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1ky",
            "description": "Open fracture of the distal radius, unspecified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/413b-g634",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9404,
        "version_name": "Fracture of wrist",
        "version_date": "2026-06-08T20:10:19.559903Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]