[ { "phenotype_id": "PH4198", "phenotype_version_id": 9416, "name": "Heart failure", "definition": "Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x\\-ray presumed to be cardiac dysfunction.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:11:03.179408Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:11:03.173978Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Systolic heart failure (disorder)", "value": 289325 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 10239, "concept_version_id": 17724, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4198", "phenotype_version_id": 9416, "phenotype_name": "Heart failure", "code_attribute_header": [ "type" ], "codes": [ { "code": "1076", "description": "heart failure/pulmonary odema", "attributes": { "type": "any" } } ] }, { "concept_id": 10240, "concept_version_id": 17725, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4198", "phenotype_version_id": 9416, "phenotype_name": "Heart failure", "code_attribute_header": [ "type" ], "codes": [ { "code": "I11.0", "description": "Hypertensive heart disease with (congestive) heart failure", "attributes": { "type": "any" } }, { "code": "I13.0", "description": "Hypertensive heart and renal disease with (congestive) heart failure", "attributes": { "type": "any" } }, { "code": "I13.2", "description": "Hypertensive heart and renal disease with both (congestive) heart failure and renal failure", "attributes": { "type": "any" } }, { "code": "I50", "description": "Heart failure", "attributes": { "type": "any" } } ] }, { "concept_id": 10241, "concept_version_id": 17726, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4198", "phenotype_version_id": 9416, "phenotype_name": "Heart failure", "code_attribute_header": [ "type" ], "codes": [ { "code": "I11.0", "description": "Hypertensive heart disease with (congestive) heart failure", "attributes": { "type": "any" } }, { "code": "I13.0", "description": "Hypertensive heart and renal disease with (congestive) heart failure", "attributes": { "type": "any" } }, { "code": "I13.2", "description": "Hypertensive heart and renal disease with both (congestive) heart failure and renal failure", "attributes": { "type": "any" } }, { "code": "I50", "description": "Heart failure", "attributes": { "type": "any" } } ] }, { "concept_id": 10242, "concept_version_id": 17727, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4198", "phenotype_version_id": 9416, "phenotype_name": "Heart failure", "code_attribute_header": [ "type" ], "codes": [ { "code": "I11.0", "description": "Hypertensive heart disease with (congestive) heart failure", "attributes": { "type": "any" } }, { "code": "I13.0", "description": "Hypertensive heart and renal disease with (congestive) heart failure", "attributes": { "type": "any" } }, { "code": "I13.2", "description": "Hypertensive heart and renal disease with both (congestive) heart failure and renal failure", "attributes": { "type": "any" } }, { "code": "I50", "description": "Heart failure", "attributes": { "type": "any" } } ] }, { "concept_id": 10243, "concept_version_id": 17728, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4198", "phenotype_version_id": 9416, "phenotype_name": "Heart failure", "code_attribute_header": [ "type" ], "codes": [ { "code": "I11.0", "description": "Hypertensive heart disease with (congestive) heart failure", "attributes": { "type": "any" } }, { "code": "I13.0", "description": "Hypertensive heart and renal disease with (congestive) heart failure", "attributes": { "type": "any" } }, { "code": "I13.2", "description": "Hypertensive heart and renal disease with both (congestive) heart failure and renal failure", "attributes": { "type": "any" } }, { "code": "I50", "description": "Heart failure", "attributes": { "type": "any" } } ] }, { "concept_id": 10244, "concept_version_id": 17729, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4198", "phenotype_version_id": 9416, "phenotype_name": "Heart failure", "code_attribute_header": [ "type" ], "codes": [ { "code": "14A6.00", "description": "H/O: heart failure", "attributes": { "type": "prevalent" } }, { "code": "14AM.00", "description": "H/O: Heart failure in last year", "attributes": { "type": "prevalent" } }, { "code": "1O1..00", "description": "Heart failure confirmed", "attributes": { "type": "any" } }, { "code": "388D.00", "description": "New York Heart Assoc classification heart failure symptoms", "attributes": { "type": "any" } }, { "code": "661M500", "description": "Heart failure self-management plan agreed", "attributes": { "type": "any" } }, { "code": "662f.00", "description": "New York Heart Association classification - class I", "attributes": { "type": "any" } }, { "code": "662g.00", "description": "New York Heart Association classification - class II", "attributes": { "type": "any" } }, { "code": "662h.00", "description": "New York Heart Association classification - class III", "attributes": { "type": "any" } }, { "code": "662i.00", "description": "New York Heart Association classification - class IV", "attributes": { "type": "any" } }, { "code": "662p.00", "description": "Heart failure 6 month review", "attributes": { "type": "prevalent" } }, { "code": "662T.00", "description": "Congestive heart failure monitoring", "attributes": { "type": "prevalent" } }, { "code": "662W.00", "description": "Heart failure annual review", "attributes": { "type": "prevalent" } }, { "code": "679W100", "description": "Education about deteriorating heart failure", "attributes": { "type": "any" } }, { "code": "679X.00", "description": "Heart failure education", "attributes": { "type": "any" } }, { "code": "8B29.00", "description": "Cardiac failure therapy", "attributes": { "type": "any" } }, { "code": "8CeC.00", "description": "Preferred place of care for next exacerbation heart failure", "attributes": { "type": "any" } }, { "code": "8CL3.00", "description": "Heart failure care plan discussed with patient", "attributes": { "type": "any" } }, { "code": "8CMK.00", "description": "Has heart failure management plan", "attributes": { "type": "any" } }, { "code": "8CMW800", "description": "Heart failure clinical pathway", "attributes": { "type": "any" } }, { "code": "8H2S.00", "description": "Admit heart failure emergency", "attributes": { "type": "any" } }, { "code": "8HBE.00", "description": "Heart failure follow-up", "attributes": { "type": "prevalent" } }, { "code": "8HHz.00", "description": "Referral to heart failure exercise programme", "attributes": { "type": "any" } }, { "code": "8Hk0.00", "description": "Referred to heart failure education group", "attributes": { "type": "any" } }, { "code": "9h1..00", "description": "Exception reporting: LVD quality indicators", "attributes": { "type": "prevalent" } }, { "code": "9h11.00", "description": "Excepted from LVD quality indicators: Patient unsuitable", "attributes": { "type": "prevalent" } }, { "code": "9h12.00", "description": "Excepted from LVD quality indicators: Informed dissent", "attributes": { "type": "prevalent" } }, { "code": "9hH..00", "description": "Exception reporting: heart failure quality indicators", "attributes": { "type": "prevalent" } }, { "code": "9hH0.00", "description": "Excepted heart failure quality indicators: Patient unsuitabl", "attributes": { "type": "any" } }, { "code": "9hH1.00", "description": "Excepted heart failure quality indicators: Informed dissent", "attributes": { "type": "any" } }, { "code": "9N2p.00", "description": "Seen by community heart failure nurse", "attributes": { "type": "any" } }, { "code": "9N6T.00", "description": "Referred by heart failure nurse specialist", "attributes": { "type": "any" } }, { "code": "9On..00", "description": "Left ventricular dysfunction monitoring administration", "attributes": { "type": "prevalent" } }, { "code": "9On0.00", "description": "Left ventricular dysfunction monitoring first letter", "attributes": { "type": "prevalent" } }, { "code": "9On1.00", "description": "Left ventricular dysfunction monitoring second letter", "attributes": { "type": "prevalent" } }, { "code": "9On2.00", "description": "Left ventricular dysfunction monitoring third letter", "attributes": { "type": "prevalent" } }, { "code": "9On3.00", "description": "Left ventricular dysfunction monitoring verbal invite", "attributes": { "type": "prevalent" } }, { "code": "9On4.00", "description": "Left ventricular dysfunction monitoring telephone invite", "attributes": { "type": "prevalent" } }, { "code": "9Or..00", "description": "Heart failure monitoring administration", "attributes": { "type": "prevalent" } }, { "code": "9Or0.00", "description": "Heart failure review completed", "attributes": { "type": "prevalent" } }, { "code": "9Or1.00", "description": "Heart failure monitoring telephone invite", "attributes": { "type": "prevalent" } }, { "code": "9Or2.00", "description": "Heart failure monitoring verbal invite", "attributes": { "type": "prevalent" } }, { "code": "9Or3.00", "description": "Heart failure monitoring first letter", "attributes": { "type": "prevalent" } }, { "code": "9Or4.00", "description": "Heart failure monitoring second letter", "attributes": { "type": "prevalent" } }, { "code": "9Or5.00", "description": "Heart failure monitoring third letter", "attributes": { "type": "prevalent" } }, { "code": "G1yz100", "description": "Rheumatic left ventricular failure", "attributes": { "type": "any" } }, { "code": "G210100", "description": "Malignant hypertensive heart disease with CCF", "attributes": { "type": "any" } }, { "code": "G211100", "description": "Benign hypertensive heart disease with CCF", "attributes": { "type": "any" } }, { "code": "G21z100", "description": "Hypertensive heart disease NOS with CCF", "attributes": { "type": "any" } }, { "code": "G232.00", "description": "Hypertensive heart&renal dis wth (congestive) heart failure", "attributes": { "type": "any" } }, { "code": "G234.00", "description": "Hyperten heart&renal dis+both(congestv)heart and renal fail", "attributes": { "type": "any" } }, { "code": "G400.00", "description": "Acute cor pulmonale", "attributes": { "type": "any" } }, { "code": "G41z.11", "description": "Chronic cor pulmonale", "attributes": { "type": "any" } }, { "code": "G554000", "description": "Congestive cardiomyopathy", "attributes": { "type": "any" } }, { "code": "G554011", "description": "Congestive obstructive cardiomyopathy", "attributes": { "type": "any" } }, { "code": "G58..00", "description": "Heart failure", "attributes": { "type": "any" } }, { "code": "G580.00", "description": "Congestive heart failure", "attributes": { "type": "any" } }, { "code": "G580000", "description": "Acute congestive heart failure", "attributes": { "type": "any" } }, { "code": "G580100", "description": "Chronic congestive heart failure", "attributes": { "type": "any" } }, { "code": "G580.11", "description": "Congestive cardiac failure", "attributes": { "type": "any" } }, { "code": "G580.12", "description": "Right heart failure", "attributes": { "type": "any" } }, { "code": "G580.13", "description": "Right ventricular failure", "attributes": { "type": "any" } }, { "code": "G580.14", "description": "Biventricular failure", "attributes": { "type": "any" } }, { "code": "G580200", "description": "Decompensated cardiac failure", "attributes": { "type": "any" } }, { "code": "G580300", "description": "Compensated cardiac failure", "attributes": { "type": "any" } }, { "code": "G580400", "description": "Congestive heart failure due to valvular disease", "attributes": { "type": "any" } }, { "code": "G581.00", "description": "Left ventricular failure", "attributes": { "type": "any" } }, { "code": "G581000", "description": "Acute left ventricular failure", "attributes": { "type": "any" } }, { "code": "G58..11", "description": "Cardiac failure", "attributes": { "type": "any" } }, { "code": "G581.11", "description": "Asthma - cardiac", "attributes": { "type": "any" } }, { "code": "G581.13", "description": "Impaired left ventricular function", "attributes": { "type": "any" } }, { "code": "G582.00", "description": "Acute heart failure", "attributes": { "type": "any" } }, { "code": "G584.00", "description": "Right ventricular failure", "attributes": { "type": "any" } }, { "code": "G58z.00", "description": "Heart failure NOS", "attributes": { "type": "any" } }, { "code": "G58z.12", "description": "Cardiac failure NOS", "attributes": { "type": "any" } }, { "code": "G5yy900", "description": "Left ventricular systolic dysfunction", "attributes": { "type": "any" } }, { "code": "G5yyA00", "description": "Left ventricular diastolic dysfunction", "attributes": { "type": "any" } }, { "code": "X202l", "description": "Right ventricular failure", "attributes": { "type": "any" } }, { "code": "XaBLt", "description": "Cardiac failure therapy", "attributes": { "type": "any" } }, { "code": "XaBwi", "description": "H/O: Heart failure in last year", "attributes": { "type": "prevalent" } }, { "code": "XaIIq", "description": "Left ventricular systolic dysfunction", "attributes": { "type": "any" } }, { "code": "XaIIU", "description": "Congestive heart failure monitoring", "attributes": { "type": "prevalent" } }, { "code": "XaIL7", "description": "New York Heart Association classification of heart failure symptoms", "attributes": { "type": "any" } }, { "code": "XaIpn", "description": "Heart failure confirmed", "attributes": { "type": "any" } }, { "code": "XaIQM", "description": "Heart failure follow-up", "attributes": { "type": "prevalent" } }, { "code": "XaIQN", "description": "Heart failure annual review", "attributes": { "type": "prevalent" } }, { "code": "XaItG", "description": "Left ventricular diastolic dysfunction", "attributes": { "type": "any" } }, { "code": "XaJ4N", "description": "Exception reporting: LVD quality indicators", "attributes": { "type": "prevalent" } }, { "code": "XaJ4Y", "description": "Excepted from LVD quality indicators: Patient unsuitable", "attributes": { "type": "prevalent" } }, { "code": "XaJ4Z", "description": "Excepted from LVD quality indicators: Informed dissent", "attributes": { "type": "prevalent" } }, { "code": "XaJ9G", "description": "New York Heart Association classification - class I", "attributes": { "type": "any" } }, { "code": "XaJ9H", "description": "New York Heart Association classification - class II", "attributes": { "type": "any" } }, { "code": "XaJ9I", "description": "New York Heart Association classification - class III", "attributes": { "type": "any" } }, { "code": "XaJ9J", "description": "New York Heart Association classification - class IV", "attributes": { "type": "any" } }, { "code": "XaK6a", "description": "Left ventricular dysfunction monitoring third letter", "attributes": { "type": "prevalent" } }, { "code": "XaK6W", "description": "Left ventricular dysfunction monitoring administration", "attributes": { "type": "prevalent" } }, { "code": "XaK6Y", "description": "Left ventricular dysfunction monitoring first letter", "attributes": { "type": "prevalent" } }, { "code": "XaK6Z", "description": "Left ventricular dysfunction monitoring second letter", "attributes": { "type": "prevalent" } }, { "code": "XaKc0", "description": "Left ventricular dysfunction monitoring verbal invite", "attributes": { "type": "prevalent" } }, { "code": "XaKNa", "description": "Seen by community heart failure nurse", "attributes": { "type": "any" } }, { "code": "XaKNW", "description": "Admit heart failure emergency", "attributes": { "type": "any" } }, { "code": "XaLCj", "description": "Referred by heart failure nurse specialist", "attributes": { "type": "any" } }, { "code": "XaLMx", "description": "Referral to heart failure exercise programme", "attributes": { "type": "any" } }, { "code": "XaLN6", "description": "Heart failure monitoring administration", "attributes": { "type": "prevalent" } }, { "code": "XaLN7", "description": "Heart failure review completed", "attributes": { "type": "prevalent" } }, { "code": "XaLNA", "description": "Heart failure care plan discussed with patient", "attributes": { "type": "any" } }, { "code": "XaLon", "description": "Heart failure 6 month review", "attributes": { "type": "prevalent" } }, { "code": "XaLSI", "description": "Referred to heart failure education group", "attributes": { "type": "any" } }, { "code": "XaMFr", "description": "Heart failure monitoring telephone invite", "attributes": { "type": "prevalent" } }, { "code": "XaMGm", "description": "Left ventricular dysfunction monitoring telephone invite", "attributes": { "type": "prevalent" } }, { "code": "XaMGo", "description": "Heart failure monitoring verbal invite", "attributes": { "type": "prevalent" } }, { "code": "XaMGs", "description": "Heart failure monitoring first letter", "attributes": { "type": "prevalent" } }, { "code": "XaMGt", "description": "Heart failure monitoring second letter", "attributes": { "type": "prevalent" } }, { "code": "XaMGu", "description": "Heart failure monitoring third letter", "attributes": { "type": "prevalent" } }, { "code": "XaMJ9", "description": "Exception reporting: heart failure quality indicators", "attributes": { "type": "prevalent" } }, { "code": "XaMJA", "description": "Excepted from heart failure quality indicators: Patient unsuitable", "attributes": { "type": "prevalent" } }, { "code": "XaMJB", "description": "Excepted from heart failure quality indicators: Informed dissent", "attributes": { "type": "prevalent" } }, { "code": "XaNUf", "description": "Heart failure education", "attributes": { "type": "any" } }, { "code": "XaO5n", "description": "Congestive heart failure due to valvular disease", "attributes": { "type": "any" } }, { "code": "XaXkR", "description": "Has heart failure management plan", "attributes": { "type": "any" } }, { "code": "XaXzw", "description": "Preferred place of care for next exacerbation of heart failure", "attributes": { "type": "any" } }, { "code": "XaYbC", "description": "Heart failure self-management plan agreed", "attributes": { "type": "any" } }, { "code": "XaYft", "description": "Education about deteriorating heart failure", "attributes": { "type": "any" } }, { "code": "XaZih", "description": "Heart failure clinical pathway", "attributes": { "type": "any" } }, { "code": "XE0Un", "description": "Chronic pulmonary heart disease NOS", "attributes": { "type": "any" } }, { "code": "XE0Uz", "description": "Congestive cardiomyopathy", "attributes": { "type": "any" } }, { "code": "XE0V9", "description": "Heart failure NOS", "attributes": { "type": "any" } }, { "code": "XE2QG", "description": "Left ventricular failure", "attributes": { "type": "any" } }, { "code": "ZRad.00", "description": "New York Heart Assoc classification heart failure symptoms", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/sdx3-kx56", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9416, "version_name": "Heart failure", "version_date": "2026-06-08T20:11:03.191323Z", "is_published": true, "is_latest": true } ] } ]