[ { "phenotype_id": "PH4204", "phenotype_version_id": 9422, "name": "Hypertension", "definition": "Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:11:21.359565Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:11:21.354152Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Hypertensive disorder, systemic arterial (disorder)", "value": 298769 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 10274, "concept_version_id": 17759, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4204", "phenotype_version_id": 9422, "phenotype_name": "Hypertension", "code_attribute_header": [ "type" ], "codes": [ { "code": "1072", "description": "essential hypertension", "attributes": { "type": "any" } } ] }, { "concept_id": 10275, "concept_version_id": 17760, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4204", "phenotype_version_id": 9422, "phenotype_name": "Hypertension", "code_attribute_header": [ "type" ], "codes": [ { "code": "I10", "description": "Essential (primary) hypertension", "attributes": { "type": "any" } }, { "code": "I11", "description": "Hypertensive heart disease", "attributes": { "type": "any" } }, { "code": "I12", "description": "Hypertensive renal disease", "attributes": { "type": "any" } }, { "code": "I13", "description": "Hypertensive heart and renal disease", "attributes": { "type": "any" } }, { "code": "I15", "description": "Secondary hypertension", "attributes": { "type": "any" } } ] }, { "concept_id": 10276, "concept_version_id": 17761, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4204", "phenotype_version_id": 9422, "phenotype_name": "Hypertension", "code_attribute_header": [ "type" ], "codes": [ { "code": "I10", "description": "Essential (primary) hypertension", "attributes": { "type": "any" } }, { "code": "I11", "description": "Hypertensive heart disease", "attributes": { "type": "any" } }, { "code": "I12", "description": "Hypertensive renal disease", "attributes": { "type": "any" } }, { "code": "I13", "description": "Hypertensive heart and renal disease", "attributes": { "type": "any" } }, { "code": "I15", "description": "Secondary hypertension", "attributes": { "type": "any" } } ] }, { "concept_id": 10277, "concept_version_id": 17762, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4204", "phenotype_version_id": 9422, "phenotype_name": "Hypertension", "code_attribute_header": [ "type" ], "codes": [ { "code": "I10", "description": "Essential (primary) hypertension", "attributes": { "type": "any" } }, { "code": "I11", "description": "Hypertensive heart disease", "attributes": { "type": "any" } }, { "code": "I12", "description": "Hypertensive renal disease", "attributes": { "type": "any" } }, { "code": "I13", "description": "Hypertensive heart and renal disease", "attributes": { "type": "any" } }, { "code": "I15", "description": "Secondary hypertension", "attributes": { "type": "any" } } ] }, { "concept_id": 10278, "concept_version_id": 17763, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4204", "phenotype_version_id": 9422, "phenotype_name": "Hypertension", "code_attribute_header": [ "type" ], "codes": [ { "code": "I10", "description": "Essential (primary) hypertension", "attributes": { "type": "any" } }, { "code": "I11", "description": "Hypertensive heart disease", "attributes": { "type": "any" } }, { "code": "I12", "description": "Hypertensive renal disease", "attributes": { "type": "any" } }, { "code": "I13", "description": "Hypertensive heart and renal disease", "attributes": { "type": "any" } }, { "code": "I15", "description": "Secondary hypertension", "attributes": { "type": "any" } } ] }, { "concept_id": 10279, "concept_version_id": 17764, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4204", "phenotype_version_id": 9422, "phenotype_name": "Hypertension", "code_attribute_header": [ "type" ], "codes": [ { "code": "14A2.00", "description": "H/O: hypertension", "attributes": { "type": "prevalent" } }, { "code": "21261", "description": "Hypertension resolved", "attributes": { "type": "any" } }, { "code": "2126100", "description": "Hypertension resolved", "attributes": { "type": "any" } }, { "code": "212K.00", "description": "Hypertension resolved", "attributes": { "type": "any" } }, { "code": "6146200", "description": "Hypertension induced by oral contraceptive pill", "attributes": { "type": "any" } }, { "code": "6624", "description": "Borderline hyperten:yearly obs", "attributes": { "type": "any" } }, { "code": "6627", "description": "Good hypertension control", "attributes": { "type": "any" } }, { "code": "6628", "description": "Poor hypertension control", "attributes": { "type": "any" } }, { "code": "662b.00", "description": "Moderate hypertension control", "attributes": { "type": "any" } }, { "code": "662c.00", "description": "Hypertension six month review", "attributes": { "type": "prevalent" } }, { "code": "662d.00", "description": "Hypertension annual review", "attributes": { "type": "prevalent" } }, { "code": "662F.00", "description": "Hypertension treatm. started", "attributes": { "type": "any" } }, { "code": "662G.00", "description": "Hypertensive treatm.changed", "attributes": { "type": "any" } }, { "code": "662O.00", "description": "On treatment for hypertension", "attributes": { "type": "any" } }, { "code": "662r.00", "description": "Trial withdrawal of antihypertensive therapy", "attributes": { "type": "any" } }, { "code": "7Q01.00", "description": "High cost hypertension drugs", "attributes": { "type": "any" } }, { "code": "8B26.00", "description": "Antihypertensive therapy", "attributes": { "type": "any" } }, { "code": "8BL0.00", "description": "Patient on maximal tolerated antihypertensive therapy", "attributes": { "type": "any" } }, { "code": "8I3N.00", "description": "Hypertension treatment refused", "attributes": { "type": "any" } }, { "code": "9OI9.00", "description": "Hypertens.monitor deleted", "attributes": { "type": "any" } }, { "code": "F404200", "description": "Blind hypertensive eye", "attributes": { "type": "any" } }, { "code": "F4211", "description": "Hypertensive retinopathy", "attributes": { "type": "any" } }, { "code": "F421300", "description": "Hypertensive retinopathy", "attributes": { "type": "any" } }, { "code": "G2...00", "description": "Hypertensive disease", "attributes": { "type": "any" } }, { "code": "G20..00", "description": "Essential hypertension", "attributes": { "type": "any" } }, { "code": "G200.00", "description": "Malignant essential hypertension", "attributes": { "type": "any" } }, { "code": "G201.00", "description": "Benign essential hypertension", "attributes": { "type": "any" } }, { "code": "G202.00", "description": "Systolic hypertension", "attributes": { "type": "any" } }, { "code": "G203.00", "description": "Diastolic hypertension", "attributes": { "type": "any" } }, { "code": "G20z.00", "description": "Essential hypertension NOS", "attributes": { "type": "any" } }, { "code": "G20z.11", "description": "Hypertension NOS", "attributes": { "type": "any" } }, { "code": "G21..00", "description": "Hypertensive heart disease", "attributes": { "type": "any" } }, { "code": "G210.00", "description": "Malignant hypertensive heart disease", "attributes": { "type": "any" } }, { "code": "G210000", "description": "Malignant hypertensive heart disease without CCF", "attributes": { "type": "any" } }, { "code": "G210100", "description": "Malignant hypertensive heart disease with CCF", "attributes": { "type": "any" } }, { "code": "G2...11", "description": "BP - hypertensive disease", "attributes": { "type": "any" } }, { "code": "G211.00", "description": "Benign hypertensive heart disease", "attributes": { "type": "any" } }, { "code": "G211000", "description": "Benign hypertensive heart disease without CCF", "attributes": { "type": "any" } }, { "code": "G211100", "description": "Benign hypertensive heart disease with CCF", "attributes": { "type": "any" } }, { "code": "G21z.", "description": "Hypertensive heart disease NOS", "attributes": { "type": "any" } }, { "code": "G21z.00", "description": "Hypertensive heart disease NOS", "attributes": { "type": "any" } }, { "code": "G21z000", "description": "Hypertensive heart disease NOS without CCF", "attributes": { "type": "any" } }, { "code": "G21z011", "description": "Cardiomegaly - hypertensive", "attributes": { "type": "any" } }, { "code": "G21z100", "description": "Hypertensive heart disease NOS with CCF", "attributes": { "type": "any" } }, { "code": "G21zz00", "description": "Hypertensive heart disease NOS", "attributes": { "type": "any" } }, { "code": "G22..00", "description": "Hypertensive renal disease", "attributes": { "type": "any" } }, { "code": "G220.00", "description": "Malignant hypertensive renal disease", "attributes": { "type": "any" } }, { "code": "G221.00", "description": "Benign hypertensive renal disease", "attributes": { "type": "any" } }, { "code": "G222.00", "description": "Hypertensive renal disease with renal failure", "attributes": { "type": "any" } }, { "code": "G22z.00", "description": "Hypertensive renal disease NOS", "attributes": { "type": "any" } }, { "code": "G22z.11", "description": "Renal hypertension", "attributes": { "type": "any" } }, { "code": "G23..00", "description": "Hypertensive heart and renal disease", "attributes": { "type": "any" } }, { "code": "G230.00", "description": "Malignant hypertensive heart and renal disease", "attributes": { "type": "any" } }, { "code": "G231.00", "description": "Benign hypertensive heart and renal disease", "attributes": { "type": "any" } }, { "code": "G232.00", "description": "Hypertensive heart&renal dis wth (congestive) heart failure", "attributes": { "type": "any" } }, { "code": "G233.00", "description": "Hypertensive heart and renal disease with renal failure", "attributes": { "type": "any" } }, { "code": "G234.00", "description": "Hyperten heart&renal dis+both(congestv)heart and renal fail", "attributes": { "type": "any" } }, { "code": "G23z.00", "description": "Hypertensive heart and renal disease NOS", "attributes": { "type": "any" } }, { "code": "G24..00", "description": "Secondary hypertension", "attributes": { "type": "any" } }, { "code": "G240.00", "description": "Secondary malignant hypertension", "attributes": { "type": "any" } }, { "code": "G240000", "description": "Secondary malignant renovascular hypertension", "attributes": { "type": "any" } }, { "code": "G240z00", "description": "Secondary malignant hypertension NOS", "attributes": { "type": "any" } }, { "code": "G241.00", "description": "Secondary benign hypertension", "attributes": { "type": "any" } }, { "code": "G241000", "description": "Secondary benign renovascular hypertension", "attributes": { "type": "any" } }, { "code": "G241z00", "description": "Secondary benign hypertension NOS", "attributes": { "type": "any" } }, { "code": "G244.00", "description": "Hypertension secondary to endocrine disorders", "attributes": { "type": "any" } }, { "code": "G24z.", "description": "Secondary hypertension NOS", "attributes": { "type": "any" } }, { "code": "G24z.00", "description": "Secondary hypertension NOS", "attributes": { "type": "any" } }, { "code": "G24z000", "description": "Secondary renovascular hypertension NOS", "attributes": { "type": "any" } }, { "code": "G24z100", "description": "Hypertension secondary to drug", "attributes": { "type": "any" } }, { "code": "G24zz00", "description": "Secondary hypertension NOS", "attributes": { "type": "any" } }, { "code": "G2y..00", "description": "Other specified hypertensive disease", "attributes": { "type": "any" } }, { "code": "G2z..00", "description": "Hypertensive disease NOS", "attributes": { "type": "any" } }, { "code": "G672.00", "description": "Hypertensive encephalopathy", "attributes": { "type": "any" } }, { "code": "G672.11", "description": "Hypertensive crisis", "attributes": { "type": "any" } }, { "code": "Gyu2.00", "description": "[X]Hypertensive diseases", "attributes": { "type": "any" } }, { "code": "Gyu2100", "description": "[X]Hypertension secondary to other renal disorders", "attributes": { "type": "any" } }, { "code": "L122.00", "description": "Other pre-existing hypertension in preg/childbirth/puerp", "attributes": { "type": "any" } }, { "code": "L122000", "description": "Other pre-existing hypertension in preg/childb/puerp unspec", "attributes": { "type": "any" } }, { "code": "L122100", "description": "Other pre-existing hypertension in preg/childb/puerp - deliv", "attributes": { "type": "any" } }, { "code": "L122300", "description": "Other pre-exist hypertension in preg/childb/puerp-not deliv", "attributes": { "type": "any" } }, { "code": "L122z00", "description": "Other pre-existing hypertension in preg/childb/puerp NOS", "attributes": { "type": "any" } }, { "code": "L127.00", "description": "Pre-eclampsia or eclampsia with pre-existing hypertension", "attributes": { "type": "any" } }, { "code": "L127z00", "description": "Pre-eclampsia or eclampsia + pre-existing hypertension NOS", "attributes": { "type": "any" } }, { "code": "L128.00", "description": "Pre-exist hypertension compl preg childbirth and puerperium", "attributes": { "type": "any" } }, { "code": "L128000", "description": "Pre-exist hyperten heart dis compl preg childbth+puerperium", "attributes": { "type": "any" } }, { "code": "L128200", "description": "Pre-exist 2ndry hypertens comp preg childbth and puerperium", "attributes": { "type": "any" } }, { "code": "TJC7.00", "description": "Adverse reaction to other antihypertensives", "attributes": { "type": "any" } }, { "code": "TJC7z00", "description": "Adverse reaction to antihypertensives NOS", "attributes": { "type": "any" } }, { "code": "U60C500", "description": "[X]Oth antihyperten drug caus advers eff in therap use, NEC", "attributes": { "type": "any" } }, { "code": "U60C511", "description": "[X] Adverse reaction to other antihypertensives", "attributes": { "type": "any" } }, { "code": "U60C51A", "description": "[X] Adverse reaction to antihypertensives NOS", "attributes": { "type": "any" } }, { "code": "Xa8HD", "description": "On treatment for hypertension", "attributes": { "type": "any" } }, { "code": "XaBLq", "description": "Antihypertensive therapy", "attributes": { "type": "any" } }, { "code": "XaIy8", "description": "Moderate hypertension control", "attributes": { "type": "any" } }, { "code": "XaIyC", "description": "Hypertension treatment refused", "attributes": { "type": "any" } }, { "code": "XaIyD", "description": "Hypertension six month review", "attributes": { "type": "prevalent" } }, { "code": "XaIyE", "description": "Hypertension annual review", "attributes": { "type": "prevalent" } }, { "code": "XaJ5h", "description": "Patient on maximal tolerated antihypertensive therapy", "attributes": { "type": "any" } }, { "code": "XaM5f", "description": "High cost hypertension drugs", "attributes": { "type": "any" } }, { "code": "XaNFs", "description": "Trial withdrawal of antihypertensive therapy", "attributes": { "type": "any" } }, { "code": "XE0Uc", "description": "Essential hypertension", "attributes": { "type": "any" } }, { "code": "XE0Ud", "description": "Essential hypertension NOS", "attributes": { "type": "any" } }, { "code": "XE0Uf", "description": "Hypertensive renal disease", "attributes": { "type": "any" } }, { "code": "XE0Ug", "description": "Hypertensive renal disease NOS", "attributes": { "type": "any" } }, { "code": "XE0VM", "description": "Hypertensive encephalopathy", "attributes": { "type": "any" } }, { "code": "XE15r", "description": "Blind hypertensive eye", "attributes": { "type": "any" } }, { "code": "XSDSb", "description": "Diastolic hypertension", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/29tv-0j28", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9422, "version_name": "Hypertension", "version_date": "2026-06-08T20:11:21.370989Z", "is_published": true, "is_latest": true } ] } ]