[
  {
    "phenotype_id": "PH4205",
    "phenotype_version_id": 9423,
    "name": "Hyperthyroidism",
    "definition": "UKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:11:24.411263Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:11:24.405711Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Hyperthyroidism (disorder)",
        "value": 112410
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10280,
        "concept_version_id": 17765,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4205",
        "phenotype_version_id": 9423,
        "phenotype_name": "Hyperthyroidism",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1225",
            "description": "hyperthyroidism/thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "1522",
            "description": "grave's disease",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10281,
        "concept_version_id": 17766,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4205",
        "phenotype_version_id": 9423,
        "phenotype_name": "Hyperthyroidism",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E05.0",
            "description": "Thyrotoxicosis with diffuse goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.1",
            "description": "Thyrotoxicosis with toxic single thyroid nodule",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.2",
            "description": "Thyrotoxicosis with toxic multinodular goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.5",
            "description": "Thyroid crisis or storm",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.8",
            "description": "Other thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.9",
            "description": "Thyrotoxicosis, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E06.2",
            "description": "Chronic thyroiditis with transient thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H06.2",
            "description": "Dysthyroid exophthalmos",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10282,
        "concept_version_id": 17767,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4205",
        "phenotype_version_id": 9423,
        "phenotype_name": "Hyperthyroidism",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E05.0",
            "description": "Thyrotoxicosis with diffuse goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.1",
            "description": "Thyrotoxicosis with toxic single thyroid nodule",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.2",
            "description": "Thyrotoxicosis with toxic multinodular goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.5",
            "description": "Thyroid crisis or storm",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.8",
            "description": "Other thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.9",
            "description": "Thyrotoxicosis, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E06.2",
            "description": "Chronic thyroiditis with transient thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H06.2",
            "description": "Dysthyroid exophthalmos",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10283,
        "concept_version_id": 17768,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4205",
        "phenotype_version_id": 9423,
        "phenotype_name": "Hyperthyroidism",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E05.0",
            "description": "Thyrotoxicosis with diffuse goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.1",
            "description": "Thyrotoxicosis with toxic single thyroid nodule",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.2",
            "description": "Thyrotoxicosis with toxic multinodular goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.5",
            "description": "Thyroid crisis or storm",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.8",
            "description": "Other thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.9",
            "description": "Thyrotoxicosis, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E06.2",
            "description": "Chronic thyroiditis with transient thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H06.2",
            "description": "Dysthyroid exophthalmos",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10284,
        "concept_version_id": 17769,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4205",
        "phenotype_version_id": 9423,
        "phenotype_name": "Hyperthyroidism",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E05.0",
            "description": "Thyrotoxicosis with diffuse goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.1",
            "description": "Thyrotoxicosis with toxic single thyroid nodule",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.2",
            "description": "Thyrotoxicosis with toxic multinodular goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.5",
            "description": "Thyroid crisis or storm",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.8",
            "description": "Other thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E05.9",
            "description": "Thyrotoxicosis, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E06.2",
            "description": "Chronic thyroiditis with transient thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H06.2",
            "description": "Dysthyroid exophthalmos",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10285,
        "concept_version_id": 17770,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4205",
        "phenotype_version_id": 9423,
        "phenotype_name": "Hyperthyroidism",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1431.00",
            "description": "H/O: hyperthyroidism",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "1431.11",
            "description": "H/O: thyrotoxicosis",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "212P.00",
            "description": "Hyperthyroidism resolved",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02..00",
            "description": "Thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C020.00",
            "description": "Toxic diffuse goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C020000",
            "description": "Toxic diffuse goitre with no crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C020100",
            "description": "Toxic diffuse goitre with crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C020.11",
            "description": "Basedow's disease",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C020.12",
            "description": "Graves' disease",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C020200",
            "description": "Thyroid-associated dermopathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C020z00",
            "description": "Toxic diffuse goitre NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C021.00",
            "description": "Toxic uninodular goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C021000",
            "description": "Toxic uninodular goitre with no crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02..11",
            "description": "Hyperthyroidism",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02..12",
            "description": "Toxic goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C021z00",
            "description": "Toxic uninodular goitre NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C022.00",
            "description": "Toxic multinodular goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C022000",
            "description": "Toxic multinodular goitre with no crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C022z00",
            "description": "Toxic multinodular goitre NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C023.00",
            "description": "Toxic nodular goitre unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C023000",
            "description": "Toxic nodular goitre unspecified with no crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C023100",
            "description": "Toxic nodular goitre unspecified with crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C023z00",
            "description": "Toxic nodular goitre NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02y.00",
            "description": "Thyrotoxicosis of other specified origin",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02y000",
            "description": "Thyrotoxicosis of other specified origin with no crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02y100",
            "description": "Thyrotoxicosis of other specified origin with crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02y300",
            "description": "Thyroid crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02yz00",
            "description": "Thyrotoxicosis of other specified origin NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02z.00",
            "description": "Thyrotoxicosis without mention of goitre or other cause",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02z000",
            "description": "Thyrotoxicosis without mention of goitre or cause no crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02z100",
            "description": "Thyrotoxicosis without mention of goitre, cause with crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C02zz00",
            "description": "Thyrotoxicosis NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Cyu1300",
            "description": "Myasthenic syndrome due to thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F395400",
            "description": "Myopathy due to thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4G2000",
            "description": "Thyrotoxic exophthalmos",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "FyuBD00",
            "description": "[X]Dysthyroid exophthalmos",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G557500",
            "description": "Thyrotoxic heart disease",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "X40H3",
            "description": "Thyroid crisis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "X40Hd",
            "description": "Chronic thyroiditis with transient thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaKcQ",
            "description": "Hyperthyroidism resolved",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE104",
            "description": "Thyrotoxicosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE105",
            "description": "Toxic diffuse goitre",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE106",
            "description": "Thyrotoxicosis of other specified origin",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/qa6p-t528",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9423,
        "version_name": "Hyperthyroidism",
        "version_date": "2026-06-08T20:11:24.420775Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]