[
  {
    "phenotype_id": "PH4215",
    "phenotype_version_id": 9433,
    "name": "Intracerebral haemorrhage",
    "definition": "Bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:11:55.604737Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:11:55.597933Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Cerebral hemorrhage (disorder)",
        "value": 89504
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10338,
        "concept_version_id": 17823,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4215",
        "phenotype_version_id": 9433,
        "phenotype_name": "Intracerebral haemorrhage",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1491",
            "description": "brain haemorrhage",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10339,
        "concept_version_id": 17824,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4215",
        "phenotype_version_id": 9433,
        "phenotype_name": "Intracerebral haemorrhage",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I61",
            "description": "Intracerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I69.1",
            "description": "Sequelae of intracerebral haemorrhage",
            "attributes": {
              "type": "prevalent"
            }
          }
        ]
      },
      {
        "concept_id": 10340,
        "concept_version_id": 17825,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4215",
        "phenotype_version_id": 9433,
        "phenotype_name": "Intracerebral haemorrhage",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I61",
            "description": "Intracerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I69.1",
            "description": "Sequelae of intracerebral haemorrhage",
            "attributes": {
              "type": "prevalent"
            }
          }
        ]
      },
      {
        "concept_id": 10341,
        "concept_version_id": 17826,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4215",
        "phenotype_version_id": 9433,
        "phenotype_name": "Intracerebral haemorrhage",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I61",
            "description": "Intracerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I69.1",
            "description": "Sequelae of intracerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10342,
        "concept_version_id": 17827,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4215",
        "phenotype_version_id": 9433,
        "phenotype_name": "Intracerebral haemorrhage",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I61",
            "description": "Intracerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I69.1",
            "description": "Sequelae of intracerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10343,
        "concept_version_id": 17828,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4215",
        "phenotype_version_id": 9433,
        "phenotype_name": "Intracerebral haemorrhage",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "662o.00",
            "description": "Haemorrhagic stroke monitoring",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "7004300.0",
            "description": "Evacuation of intracerebral haematoma NEC",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G61..00",
            "description": "Intracerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G610.00",
            "description": "Cortical haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G611.00",
            "description": "Internal capsule haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G61..11",
            "description": "CVA - cerebrovascular accid due to intracerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G61..12",
            "description": "Stroke due to intracerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G612.00",
            "description": "Basal nucleus haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G613.00",
            "description": "Cerebellar haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G614.00",
            "description": "Pontine haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G615.00",
            "description": "Bulbar haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G616.00",
            "description": "External capsule haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G617.00",
            "description": "Intracerebral haemorrhage, intraventricular",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G618.00",
            "description": "Intracerebral haemorrhage, multiple localized",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G619.00",
            "description": "Lobar cerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G61X.00",
            "description": "Intracerebral haemorrhage in hemisphere, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G61X000",
            "description": "Left sided intracerebral haemorrhage, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G61X100",
            "description": "Right sided intracerebral haemorrhage, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G61z.00",
            "description": "Intracerebral haemorrhage NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G681.00",
            "description": "Sequelae of intracerebral haemorrhage",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "G682.00",
            "description": "Sequelae of other nontraumatic intracranial haemorrhage",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "Gyu6200",
            "description": "[X]Other intracerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Gyu6F00",
            "description": "[X]Intracerebral haemorrhage in hemisphere, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "X00DM",
            "description": "Lobar cerebral haemorrhage",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaBM4",
            "description": "Left sided intracerebral haemorrhage, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaBM5",
            "description": "Right sided intracerebral haemorrhage, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaKSH",
            "description": "Haemorrhagic stroke monitoring",
            "attributes": {
              "type": "prevalent"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/qqr1-jf56",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9433,
        "version_name": "Intracerebral haemorrhage",
        "version_date": "2026-06-08T20:11:55.617853Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]