[
  {
    "phenotype_id": "PH4217",
    "phenotype_version_id": 9435,
    "name": "Intrauterine hypoxia",
    "definition": "Deficient oxygenation of FETAL BLOOD.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:12:00.938340Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:12:00.932661Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Intrauterine hypoxia (disorder)",
        "value": 102014
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10349,
        "concept_version_id": 17834,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4217",
        "phenotype_version_id": 9435,
        "phenotype_name": "Intrauterine hypoxia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "P20",
            "description": "Intrauterine hypoxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "P24.0",
            "description": "Neonatal aspiration of meconium",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10350,
        "concept_version_id": 17835,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4217",
        "phenotype_version_id": 9435,
        "phenotype_name": "Intrauterine hypoxia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "P20",
            "description": "Intrauterine hypoxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "P24.0",
            "description": "Neonatal aspiration of meconium",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10351,
        "concept_version_id": 17836,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4217",
        "phenotype_version_id": 9435,
        "phenotype_name": "Intrauterine hypoxia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "P20",
            "description": "Intrauterine hypoxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "P24.0",
            "description": "Neonatal aspiration of meconium",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10352,
        "concept_version_id": 17837,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4217",
        "phenotype_version_id": 9435,
        "phenotype_name": "Intrauterine hypoxia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "P20",
            "description": "Intrauterine hypoxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "P24.0",
            "description": "Neonatal aspiration of meconium",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10353,
        "concept_version_id": 17838,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4217",
        "phenotype_version_id": 9435,
        "phenotype_name": "Intrauterine hypoxia",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "4H23.00",
            "description": "Amniotic fluid -meconium stain",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263.00",
            "description": "Fetal distress - affecting management",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263000",
            "description": "Fetal distress unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263100",
            "description": "Fetal distress - delivered",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263.11",
            "description": "Fetal acidosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263.14",
            "description": "Meconium stained liquor",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263200",
            "description": "Fetal distress with antenatal problem",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263400",
            "description": "Labour and delivery complic by meconium in amniotic fluid",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263500",
            "description": "Lab+del comp fetal ht rate anom wth meconium in amnio fluid",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263600",
            "description": "Labour+delivery complicatd by biochem evidence/fetal stress",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263700",
            "description": "Maternal care for fetal hypoxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "L263z00",
            "description": "Fetal distress NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Lyu4800",
            "description": "[X]Labour+delivery complicat/oth evidence of fetal distress",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q21..00",
            "description": "Intrauterine hypoxia and birth asphyxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q21..11",
            "description": "Intrauterine hypoxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q21..12",
            "description": "Labour fetal anoxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q212.00",
            "description": "Liveborn with prelabour fetal distress",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q212000",
            "description": "Liveborn with prelabour abnormal heart beat",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q212100",
            "description": "Liveborn with prelabour hypoxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q212.11",
            "description": "Fetal distress before labour - liveborn",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q212200",
            "description": "Liveborn with prelabour meconium in liquor",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q212z00",
            "description": "Liveborn with prelabour fetal distress NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q213.00",
            "description": "Liveborn with labour fetal distress",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q213000",
            "description": "Liveborn with labour abnormal heart beat",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q213100",
            "description": "Liveborn with labour hypoxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q213.11",
            "description": "Fetal distress in labour - liveborn",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q213200",
            "description": "Liveborn with labour meconium in liquor",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q213z00",
            "description": "Liveborn with labour fetal distress NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q214.00",
            "description": "Liveborn with fetal distress, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q214000",
            "description": "Liveborn with abnormal heart beat, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q214100",
            "description": "Liveborn with fetal hypoxia, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q214.11",
            "description": "Fetal distress, unspecified when, liveborn",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q214200",
            "description": "Liveborn with meconium liquor, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q214z00",
            "description": "Liveborn with unspecified fetal distress NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q311000",
            "description": "Meconium aspiration syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1ei",
            "description": "Intrauterine hypoxia and birth asphyxia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Z264800",
            "description": "Meconium stained liquor",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Z264900",
            "description": "Old meconium staining liquor",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Z264A00",
            "description": "Fresh meconium staining liquor",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Z264B00",
            "description": "Thick meconium stained liquor",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/mz5k-0150",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9435,
        "version_name": "Intrauterine hypoxia",
        "version_date": "2026-06-08T20:12:00.949911Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]