[ { "phenotype_id": "PH4218", "phenotype_version_id": 9436, "name": "Ischaemic stroke", "definition": "Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan\\-necrosis.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:12:03.978277Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:12:03.972152Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Ischemic stroke (disorder)", "value": 40940 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 10354, "concept_version_id": 17839, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4218", "phenotype_version_id": 9436, "phenotype_name": "Ischaemic stroke", "code_attribute_header": [ "type" ], "codes": [ { "code": "1583", "description": "ischaemic stroke", "attributes": { "type": "any" } } ] }, { "concept_id": 10355, "concept_version_id": 17840, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4218", "phenotype_version_id": 9436, "phenotype_name": "Ischaemic stroke", "code_attribute_header": [ "type" ], "codes": [ { "code": "I63.0", "description": "Cerebral infarction due to thrombosis of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.1", "description": "Cerebral infarction due to embolism of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.2", "description": "Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.3", "description": "Cerebral infarction due to thrombosis of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.4", "description": "Cerebral infarction due to embolism of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.5", "description": "Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.8", "description": "Other cerebral infarction", "attributes": { "type": "any" } }, { "code": "I63.9", "description": "Cerebral infarction, unspecified", "attributes": { "type": "any" } }, { "code": "I69.3", "description": "Sequelae of cerebral infarction", "attributes": { "type": "prevalent" } } ] }, { "concept_id": 10356, "concept_version_id": 17841, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4218", "phenotype_version_id": 9436, "phenotype_name": "Ischaemic stroke", "code_attribute_header": [ "type" ], "codes": [ { "code": "I63.0", "description": "Cerebral infarction due to thrombosis of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.1", "description": "Cerebral infarction due to embolism of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.2", "description": "Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.3", "description": "Cerebral infarction due to thrombosis of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.4", "description": "Cerebral infarction due to embolism of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.5", "description": "Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.8", "description": "Other cerebral infarction", "attributes": { "type": "any" } }, { "code": "I63.9", "description": "Cerebral infarction, unspecified", "attributes": { "type": "any" } }, { "code": "I69.3", "description": "Sequelae of cerebral infarction", "attributes": { "type": "prevalent" } } ] }, { "concept_id": 10357, "concept_version_id": 17842, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4218", "phenotype_version_id": 9436, "phenotype_name": "Ischaemic stroke", "code_attribute_header": [ "type" ], "codes": [ { "code": "I63.0", "description": "Cerebral infarction due to thrombosis of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.1", "description": "Cerebral infarction due to embolism of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.2", "description": "Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.3", "description": "Cerebral infarction due to thrombosis of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.4", "description": "Cerebral infarction due to embolism of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.5", "description": "Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.8", "description": "Other cerebral infarction", "attributes": { "type": "any" } }, { "code": "I63.9", "description": "Cerebral infarction, unspecified", "attributes": { "type": "any" } }, { "code": "I69.3", "description": "Sequelae of cerebral infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 10358, "concept_version_id": 17843, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4218", "phenotype_version_id": 9436, "phenotype_name": "Ischaemic stroke", "code_attribute_header": [ "type" ], "codes": [ { "code": "I63.0", "description": "Cerebral infarction due to thrombosis of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.1", "description": "Cerebral infarction due to embolism of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.2", "description": "Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.3", "description": "Cerebral infarction due to thrombosis of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.4", "description": "Cerebral infarction due to embolism of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.5", "description": "Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries", "attributes": { "type": "any" } }, { "code": "I63.8", "description": "Other cerebral infarction", "attributes": { "type": "any" } }, { "code": "I63.9", "description": "Cerebral infarction, unspecified", "attributes": { "type": "any" } }, { "code": "I69.3", "description": "Sequelae of cerebral infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 10359, "concept_version_id": 17844, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4218", "phenotype_version_id": 9436, "phenotype_name": "Ischaemic stroke", "code_attribute_header": [ "type" ], "codes": [ { "code": "G63..11", "description": "Infarction - precerebral", "attributes": { "type": "any" } }, { "code": "G63y000", "description": "Cerebral infarct due to thrombosis of precerebral arteries", "attributes": { "type": "any" } }, { "code": "G63y100", "description": "Cerebral infarction due to embolism of precerebral arteries", "attributes": { "type": "any" } }, { "code": "G64..00", "description": "Cerebral arterial occlusion", "attributes": { "type": "any" } }, { "code": "G640.00", "description": "Cerebral thrombosis", "attributes": { "type": "any" } }, { "code": "G640000", "description": "Cerebral infarction due to thrombosis of cerebral arteries", "attributes": { "type": "any" } }, { "code": "G641.00", "description": "Cerebral embolism", "attributes": { "type": "any" } }, { "code": "G641000", "description": "Cerebral infarction due to embolism of cerebral arteries", "attributes": { "type": "any" } }, { "code": "G64..11", "description": "CVA - cerebral artery occlusion", "attributes": { "type": "any" } }, { "code": "G641.11", "description": "Cerebral embolus", "attributes": { "type": "any" } }, { "code": "G64..12", "description": "Infarction - cerebral", "attributes": { "type": "any" } }, { "code": "G64..13", "description": "Stroke due to cerebral arterial occlusion", "attributes": { "type": "any" } }, { "code": "G64z.00", "description": "Cerebral infarction NOS", "attributes": { "type": "any" } }, { "code": "G64z000", "description": "Brainstem infarction", "attributes": { "type": "any" } }, { "code": "G64z100", "description": "Wallenberg syndrome", "attributes": { "type": "any" } }, { "code": "G64z.11", "description": "Brainstem infarction NOS", "attributes": { "type": "any" } }, { "code": "G64z111", "description": "Lateral medullary syndrome", "attributes": { "type": "any" } }, { "code": "G64z.12", "description": "Cerebellar infarction", "attributes": { "type": "any" } }, { "code": "G64z200", "description": "Left sided cerebral infarction", "attributes": { "type": "any" } }, { "code": "G64z300", "description": "Right sided cerebral infarction", "attributes": { "type": "any" } }, { "code": "G64z400", "description": "Infarction of basal ganglia", "attributes": { "type": "any" } }, { "code": "G683.00", "description": "Sequelae of cerebral infarction", "attributes": { "type": "prevalent" } }, { "code": "G6W..00", "description": "Cereb infarct due unsp occlus/stenos precerebr arteries", "attributes": { "type": "any" } }, { "code": "G6X..00", "description": "Cerebrl infarctn due/unspcf occlusn or sten/cerebrl artrs", "attributes": { "type": "any" } }, { "code": "Gyu6300", "description": "[X]Cerebrl infarctn due/unspcf occlusn or sten/cerebrl artrs", "attributes": { "type": "any" } }, { "code": "Gyu6400", "description": "[X]Other cerebral infarction", "attributes": { "type": "any" } }, { "code": "Gyu6G00", "description": "[X]Cereb infarct due unsp occlus/stenos precerebr arteries", "attributes": { "type": "any" } }, { "code": "Xa00K", "description": "Brainstem infarction", "attributes": { "type": "any" } }, { "code": "Xa00M", "description": "Wallenberg syndrome", "attributes": { "type": "any" } }, { "code": "XaBEC", "description": "Left sided cerebral infarction", "attributes": { "type": "any" } }, { "code": "XaBED", "description": "Right sided cerebral infarction", "attributes": { "type": "any" } }, { "code": "XaJgQ", "description": "Infarction of basal ganglia", "attributes": { "type": "any" } }, { "code": "XE0VG", "description": "Precerebral arterial occlusion", "attributes": { "type": "any" } }, { "code": "XE0VI", "description": "Cerebral arterial occlusion", "attributes": { "type": "any" } }, { "code": "XE0VJ", "description": "Cerebral infarction NOS", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/zkcq-0k08", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9436, "version_name": "Ischaemic stroke", "version_date": "2026-06-08T20:12:03.989613Z", "is_published": true, "is_latest": true } ] } ]