[
  {
    "phenotype_id": "PH4220",
    "phenotype_version_id": 9438,
    "name": "Keratitis",
    "definition": "Keratitis is an inflammation of the cornea — the clear, dome\\-shaped tissue on the front of your eye that covers the pupil and iris.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:12:09.604011Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:12:09.599071Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Keratitis (disorder)",
        "value": 248535
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10365,
        "concept_version_id": 17850,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4220",
        "phenotype_version_id": 9438,
        "phenotype_name": "Keratitis",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "H16",
            "description": "Keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.1",
            "description": "Herpesviral keratitis and keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.2",
            "description": "Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.3",
            "description": "Keratitis and keratoconjunctivitis in other diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10366,
        "concept_version_id": 17851,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4220",
        "phenotype_version_id": 9438,
        "phenotype_name": "Keratitis",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "H16",
            "description": "Keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.1",
            "description": "Herpesviral keratitis and keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.2",
            "description": "Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.3",
            "description": "Keratitis and keratoconjunctivitis in other diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10367,
        "concept_version_id": 17852,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4220",
        "phenotype_version_id": 9438,
        "phenotype_name": "Keratitis",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "H16",
            "description": "Keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.1",
            "description": "Herpesviral keratitis and keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.2",
            "description": "Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.3",
            "description": "Keratitis and keratoconjunctivitis in other diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10368,
        "concept_version_id": 17853,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4220",
        "phenotype_version_id": 9438,
        "phenotype_name": "Keratitis",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "H16",
            "description": "Keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.1",
            "description": "Herpesviral keratitis and keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.2",
            "description": "Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H19.3",
            "description": "Keratitis and keratoconjunctivitis in other diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10369,
        "concept_version_id": 17854,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4220",
        "phenotype_version_id": 9438,
        "phenotype_name": "Keratitis",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "A173200",
            "description": "Tuberculous interstitial keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A173400",
            "description": "Tuberculous keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A532100",
            "description": "Herpes zoster with keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A544200",
            "description": "Herpes simplex dendritic keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A544300",
            "description": "Herpes simplex disciform keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A55x000",
            "description": "Measles keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A771.00",
            "description": "Epidemic keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A776.00",
            "description": "Keratoconjunctivitis due to adenovirus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A903.00",
            "description": "Syphilitic interstitial keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A984300",
            "description": "Gonococcal keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "AD67000",
            "description": "Acanthamoeba keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A..00",
            "description": "Keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A1.00",
            "description": "Dendritic keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A..11",
            "description": "Keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A2.00",
            "description": "Other superficial keratitis without conjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A2000",
            "description": "Unspecified superficial keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A2100",
            "description": "Punctate keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A2112",
            "description": "Thygeson's superficial punctate keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A2200",
            "description": "Nummular keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A2300",
            "description": "Striate keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A2400",
            "description": "Macular keratitis NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A2500",
            "description": "Filamentary keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A2z00",
            "description": "Other superficial keratitis without conjunctivitis NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A3.00",
            "description": "Specific keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A3000",
            "description": "Phlyctenular keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A3300",
            "description": "Exposure keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A3400",
            "description": "Neurotrophic keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A3z00",
            "description": "Specific keratoconjunctivitis NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A4.00",
            "description": "Other keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A4000",
            "description": "Unspecified keratoconjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A4100",
            "description": "Keratitis or keratoconjunctivitis in other exanthemata",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A4z00",
            "description": "Other keratoconjunctivitis NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A5.00",
            "description": "Interstitial and deep keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A5000",
            "description": "Unspecified interstitial keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A5100",
            "description": "Diffuse interstitial keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A5200",
            "description": "Sclerosing keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A5400",
            "description": "Keratitis due to syphilis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A5500",
            "description": "Keratitis due to tuberculosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4A5z00",
            "description": "Interstitial and deep keratitis NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4Ay.00",
            "description": "Other forms of keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F4Az.00",
            "description": "Keratitis NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "FyuD100",
            "description": "[X]Other superficial keratitis without conjunctivitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "FyuD200",
            "description": "[X]Other keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "FyuDA00",
            "description": "[X]Keratitis+keratoconjunctivitis in other diseases CE",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "X00ab",
            "description": "Acanthamoeba keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE16N",
            "description": "Keratitis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE16R",
            "description": "Diffuse interstitial keratitis",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/t5x1-9p56",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9438,
        "version_name": "Keratitis",
        "version_date": "2026-06-08T20:12:09.610867Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]