[ { "phenotype_id": "PH423", "phenotype_version_id": 846, "name": "Hypotension Drugs", "definition": "Patient level data were extracted from the General Practice Research Database (GPRD), which contains anonymised, patient based data on morbidity, prescribing, treatment, and referral collected from over 500 general practices, covering about 7% of the UK population (4.4 million patients).14 Data are in Read code format—a hierarchical system used to code clinical data. Additional data on prescriptions and test results are available as free-text entries. We selected a sample of 148 practices that provided data to the GPRD continuously between January 2000 and December 2007, structured to include a range of list (patient panel) sizes. Selected practices were nationally representative in terms of patient sex and age distribution and area socioeconomic deprivation but had a relatively large average list size, reflecting a bias towards larger practices in the GPRD. Overall, the selected practices performed marginally better than national practices on the clinical indicators in the Quality and Outcomes Framework. A random selection of 4500 patients registered for at least one day between 1 January 2000 and 31 December 2007 was drawn from each practice. For practices with fewer than 4501 patients, all patients were selected. The final sample consisted of 653 500 patients. Patients with relevant conditions were identified from their diagnostic Read codes. Patients for whom targets were met were identified from the relevant Read codes and free-text terms.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves, Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework. BMJ, 342:d3590, 2011." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:18:52.863160Z", "author": "Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:18:52.863191Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Drug", "value": "3" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 }, { "name": "OXMIS codes", "value": 15 } ], "event_date_range": "01/01/2000 - 31/12/2007", "concept_information": [ { "concept_id": 1772, "concept_version_id": 4682, "concept_name": "Hypotension Drugs - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH423", "phenotype_version_id": 846, "phenotype_name": "Hypotension Drugs", "code_attribute_header": [ "Entity type", "Coding System (OXMIS Read)", "Category" ], "codes": [ { "code": "23D2.11", "description": "O/E - bronchospasm", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "2422.00", "description": "O/E - pulse rate - bradycardia", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "2422.11", "description": "O/E - bradycardia", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "8624.00", "description": "Hypothermia with hypotension", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "B540.11", "description": "Phaeochromocytoma", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "B7H0000", "description": "Benign phaeochromocytoma", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "BBD9.00", "description": "[M]Phaeochromocytoma NOS", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "BBDA.00", "description": "[M]Phaeochromocytoma; malignant", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "C362000", "description": "Metabolic acidosis NEC", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "F130300", "description": "Parkinsonism with orthostatic hypotension", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G331.00", "description": "Prinzmetal's angina", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G57y000", "description": "Persistent sinus bradycardia", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G57y100", "description": "Severe sinus bradycardia", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G57y300", "description": "Sick sinus syndrome", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G87..00", "description": "Hypotension", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G870.00", "description": "Orthostatic hypotension", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G870.11", "description": "Postural hypotension", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G871.00", "description": "Chronic hypotension", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G872.00", "description": "Idiopathic hypotension", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G873.00", "description": "Hypotension due to drugs", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "G87z.00", "description": "Hypotension NOS", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "Gyu9000", "description": "[X]Other hypotension", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "H061200", "description": "Acute bronchiolitis with bronchospasm", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "H5y1600", "description": "Bronchospasm", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "L263.12", "description": "Fetal bradycardia", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "L263A00", "description": "Maternal care for fetal bradycardia during pregnancy", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "L392.00", "description": "Maternal hypotension syndrome", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "L392000", "description": "Maternal hypotension syndrome unspecified", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "L392100", "description": "Maternal hypotension syndrome - delivered", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "L392200", "description": "Maternal hypotension syndrome - delivered with p/n problem", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "L392300", "description": "Maternal hypotension syndrome with antenatal problem", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "L392400", "description": "Maternal hypotension syndrome with postnatal problem", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "L392z00", "description": "Maternal hypotension syndrome NOS", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "Q448.00", "description": "Newborn late metabolic acidosis", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "Q48C.00", "description": "Neonatal hypotension", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "R055100", "description": "[D]Cardiogenic shock", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "R059.00", "description": "[D]Sinus bradycardia", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "R05W.00", "description": "[D] Bradycardia; unspecified", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } }, { "code": "Ryu0600", "description": "[X]Bradycardia; unspecified", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "Read", "Category": "drug" } } ] }, { "concept_id": 1773, "concept_version_id": 4684, "concept_name": "Hypotension Drugs - Primary Care", "coding_system": { "id": 15, "name": "OXMIS codes", "description": "OXMIS codes" }, "phenotype_id": "PH423", "phenotype_version_id": 846, "phenotype_name": "Hypotension Drugs", "code_attribute_header": [ "Entity type", "Coding System (OXMIS Read)", "Category" ], "codes": [ { "code": "2552", "description": "PHAEOCHROMOCYTOMA", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "4139PB", "description": "PRINZMETAL'S ANGINA", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "4279BR", "description": "SINUS BRADYCARDIA", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "4279G", "description": "BRADYCARDIA", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "4279PK", "description": "SICK SINUS SYNDROME", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "4580", "description": "HYPOTENSION", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "4580A", "description": "POSTURAL HYPOTENSION", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "4580AB", "description": "HYPOTENSION FIRST DOSE", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "4580T", "description": "HYPOTENSION ORTHOSTATIC", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "5199AL", "description": "BRONCHOSPASM ALLERGIC", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "5199B", "description": "BRONCHOSPASM", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "7886M", "description": "METABOLIC ACIDOSIS", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } }, { "code": "9779PH", "description": "HYPOTENSION POSTURAL DRUG INDUCED", "attributes": { "Entity type": "hypotension drugs", "Coding System (OXMIS Read)": "OXMIS", "Category": "drug" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/s48p-zy89", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 846, "version_name": "Hypotension Drugs", "version_date": "2021-10-06T16:18:52.890581Z", "is_published": true, "is_latest": true } ] } ]