[ { "phenotype_id": "PH4235", "phenotype_version_id": 9453, "name": "Meningitis", "definition": "A central nervous system disease that is characterized by an inflammation of the pia\\-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:12:57.029120Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:12:57.023532Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Meningitis (disorder)", "value": 610618 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 10453, "concept_version_id": 17938, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4235", "phenotype_version_id": 9453, "phenotype_name": "Meningitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "1247", "description": "meningitis", "attributes": { "type": "any" } } ] }, { "concept_id": 10454, "concept_version_id": 17939, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4235", "phenotype_version_id": 9453, "phenotype_name": "Meningitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "A17.0", "description": "Tuberculous meningitis", "attributes": { "type": "any" } }, { "code": "A17.1", "description": "Meningeal tuberculoma", "attributes": { "type": "any" } }, { "code": "A20.3", "description": "Plague meningitis", "attributes": { "type": "any" } }, { "code": "A32.1", "description": "Listerial meningitis and meningoencephalitis", "attributes": { "type": "any" } }, { "code": "A39.0", "description": "Meningococcal meningitis", "attributes": { "type": "any" } }, { "code": "A87", "description": "Viral meningitis", "attributes": { "type": "any" } }, { "code": "B00.3", "description": "Herpesviral meningitis", "attributes": { "type": "any" } }, { "code": "B01.0", "description": "Varicella meningitis", "attributes": { "type": "any" } }, { "code": "B02.1", "description": "Zoster meningitis", "attributes": { "type": "any" } }, { "code": "B05.1", "description": "Measles complicated by meningitis", "attributes": { "type": "any" } }, { "code": "B26.1", "description": "Mumps meningitis", "attributes": { "type": "any" } }, { "code": "B37.5", "description": "Candidal meningitis", "attributes": { "type": "any" } }, { "code": "B38.4", "description": "Coccidioidomycosis meningitis", "attributes": { "type": "any" } }, { "code": "G00", "description": "Bacterial meningitis, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "G01", "description": "Meningitis in bacterial diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G02.0", "description": "Meningitis in viral diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G02.1", "description": "Meningitis in mycoses", "attributes": { "type": "any" } }, { "code": "G02.8", "description": "Meningitis in other specified infectious and parasitic diseases classified elsewhere", "attributes": { "type": "any" } } ] }, { "concept_id": 10455, "concept_version_id": 17940, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4235", "phenotype_version_id": 9453, "phenotype_name": "Meningitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "A17.0", "description": "Tuberculous meningitis", "attributes": { "type": "any" } }, { "code": "A17.1", "description": "Meningeal tuberculoma", "attributes": { "type": "any" } }, { "code": "A20.3", "description": "Plague meningitis", "attributes": { "type": "any" } }, { "code": "A32.1", "description": "Listerial meningitis and meningoencephalitis", "attributes": { "type": "any" } }, { "code": "A39.0", "description": "Meningococcal meningitis", "attributes": { "type": "any" } }, { "code": "A87", "description": "Viral meningitis", "attributes": { "type": "any" } }, { "code": "B00.3", "description": "Herpesviral meningitis", "attributes": { "type": "any" } }, { "code": "B01.0", "description": "Varicella meningitis", "attributes": { "type": "any" } }, { "code": "B02.1", "description": "Zoster meningitis", "attributes": { "type": "any" } }, { "code": "B05.1", "description": "Measles complicated by meningitis", "attributes": { "type": "any" } }, { "code": "B26.1", "description": "Mumps meningitis", "attributes": { "type": "any" } }, { "code": "B37.5", "description": "Candidal meningitis", "attributes": { "type": "any" } }, { "code": "B38.4", "description": "Coccidioidomycosis meningitis", "attributes": { "type": "any" } }, { "code": "G00", "description": "Bacterial meningitis, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "G01", "description": "Meningitis in bacterial diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G02.0", "description": "Meningitis in viral diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G02.1", "description": "Meningitis in mycoses", "attributes": { "type": "any" } }, { "code": "G02.8", "description": "Meningitis in other specified infectious and parasitic diseases classified elsewhere", "attributes": { "type": "any" } } ] }, { "concept_id": 10456, "concept_version_id": 17941, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4235", "phenotype_version_id": 9453, "phenotype_name": "Meningitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "A17.0", "description": "Tuberculous meningitis", "attributes": { "type": "any" } }, { "code": "A17.1", "description": "Meningeal tuberculoma", "attributes": { "type": "any" } }, { "code": "A20.3", "description": "Plague meningitis", "attributes": { "type": "any" } }, { "code": "A32.1", "description": "Listerial meningitis and meningoencephalitis", "attributes": { "type": "any" } }, { "code": "A39.0", "description": "Meningococcal meningitis", "attributes": { "type": "any" } }, { "code": "A87", "description": "Viral meningitis", "attributes": { "type": "any" } }, { "code": "B00.3", "description": "Herpesviral meningitis", "attributes": { "type": "any" } }, { "code": "B01.0", "description": "Varicella meningitis", "attributes": { "type": "any" } }, { "code": "B02.1", "description": "Zoster meningitis", "attributes": { "type": "any" } }, { "code": "B05.1", "description": "Measles complicated by meningitis", "attributes": { "type": "any" } }, { "code": "B26.1", "description": "Mumps meningitis", "attributes": { "type": "any" } }, { "code": "B37.5", "description": "Candidal meningitis", "attributes": { "type": "any" } }, { "code": "B38.4", "description": "Coccidioidomycosis meningitis", "attributes": { "type": "any" } }, { "code": "G00", "description": "Bacterial meningitis, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "G01", "description": "Meningitis in bacterial diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G02.0", "description": "Meningitis in viral diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G02.1", "description": "Meningitis in mycoses", "attributes": { "type": "any" } }, { "code": "G02.8", "description": "Meningitis in other specified infectious and parasitic diseases classified elsewhere", "attributes": { "type": "any" } } ] }, { "concept_id": 10457, "concept_version_id": 17942, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4235", "phenotype_version_id": 9453, "phenotype_name": "Meningitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "A17.0", "description": "Tuberculous meningitis", "attributes": { "type": "any" } }, { "code": "A17.1", "description": "Meningeal tuberculoma", "attributes": { "type": "any" } }, { "code": "A20.3", "description": "Plague meningitis", "attributes": { "type": "any" } }, { "code": "A32.1", "description": "Listerial meningitis and meningoencephalitis", "attributes": { "type": "any" } }, { "code": "A39.0", "description": "Meningococcal meningitis", "attributes": { "type": "any" } }, { "code": "A87", "description": "Viral meningitis", "attributes": { "type": "any" } }, { "code": "B00.3", "description": "Herpesviral meningitis", "attributes": { "type": "any" } }, { "code": "B01.0", "description": "Varicella meningitis", "attributes": { "type": "any" } }, { "code": "B02.1", "description": "Zoster meningitis", "attributes": { "type": "any" } }, { "code": "B05.1", "description": "Measles complicated by meningitis", "attributes": { "type": "any" } }, { "code": "B26.1", "description": "Mumps meningitis", "attributes": { "type": "any" } }, { "code": "B37.5", "description": "Candidal meningitis", "attributes": { "type": "any" } }, { "code": "B38.4", "description": "Coccidioidomycosis meningitis", "attributes": { "type": "any" } }, { "code": "G00", "description": "Bacterial meningitis, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "G01", "description": "Meningitis in bacterial diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G02.0", "description": "Meningitis in viral diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G02.1", "description": "Meningitis in mycoses", "attributes": { "type": "any" } }, { "code": "G02.8", "description": "Meningitis in other specified infectious and parasitic diseases classified elsewhere", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/667s-0r65", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9453, "version_name": "Meningitis", "version_date": "2026-06-08T20:12:57.039350Z", "is_published": true, "is_latest": true } ] } ]