[
  {
    "phenotype_id": "PH4236",
    "phenotype_version_id": 9454,
    "name": "Menorrhagia and polymenorrhoea",
    "definition": "Menorrhagia is the medical term for menstrual periods with abnormally heavy or prolonged bleeding.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:12:59.793742Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:12:59.787897Z",
    "sex": [
      {
        "name": "Female",
        "value": "2"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Menorrhagia (finding)",
        "value": 551540
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10458,
        "concept_version_id": 17943,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4236",
        "phenotype_version_id": 9454,
        "phenotype_name": "Menorrhagia and polymenorrhoea",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1556",
            "description": "menorrhagia (unknown cause)",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10459,
        "concept_version_id": 17944,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4236",
        "phenotype_version_id": 9454,
        "phenotype_name": "Menorrhagia and polymenorrhoea",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "N92.0",
            "description": "Excessive and frequent menstruation with regular cycle",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.1",
            "description": "Excessive and frequent menstruation with irregular cycle",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.2",
            "description": "Excessive menstruation at puberty",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.4",
            "description": "Excessive bleeding in the premenopausal period",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10460,
        "concept_version_id": 17945,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4236",
        "phenotype_version_id": 9454,
        "phenotype_name": "Menorrhagia and polymenorrhoea",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "N92.0",
            "description": "Excessive and frequent menstruation with regular cycle",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.1",
            "description": "Excessive and frequent menstruation with irregular cycle",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.2",
            "description": "Excessive menstruation at puberty",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.4",
            "description": "Excessive bleeding in the premenopausal period",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10461,
        "concept_version_id": 17946,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4236",
        "phenotype_version_id": 9454,
        "phenotype_name": "Menorrhagia and polymenorrhoea",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "N92.0",
            "description": "Excessive and frequent menstruation with regular cycle",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.1",
            "description": "Excessive and frequent menstruation with irregular cycle",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.2",
            "description": "Excessive menstruation at puberty",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.4",
            "description": "Excessive bleeding in the premenopausal period",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10462,
        "concept_version_id": 17947,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4236",
        "phenotype_version_id": 9454,
        "phenotype_name": "Menorrhagia and polymenorrhoea",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "N92.0",
            "description": "Excessive and frequent menstruation with regular cycle",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.1",
            "description": "Excessive and frequent menstruation with irregular cycle",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.2",
            "description": "Excessive menstruation at puberty",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N92.4",
            "description": "Excessive bleeding in the premenopausal period",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10463,
        "concept_version_id": 17948,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4236",
        "phenotype_version_id": 9454,
        "phenotype_name": "Menorrhagia and polymenorrhoea",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "151G.00",
            "description": "Length of cycle decreasing",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "1572.00",
            "description": "H/O: polymenorrhoea",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "1573.00",
            "description": "H/O: menorrhagia",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "1573.11",
            "description": "H/O: heavy periods",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "K592.00",
            "description": "Excessive or frequent menstruation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K592000",
            "description": "Menorrhagia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K592011",
            "description": "Heavy periods",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K592012",
            "description": "Heavy menstrual bleeding",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K592100",
            "description": "Polymenorrhoea",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K592.11",
            "description": "Frequent menses",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K592111",
            "description": "Epimenorrhoea",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K592.12",
            "description": "Hypermenorrhoea",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K592z00",
            "description": "Excessive or frequent menstruation NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K593.11",
            "description": "Pubertal bleeding and menorrhagia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K5A0.00",
            "description": "Premenopausal menorrhagia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K5A0.11",
            "description": "Climacteric menorrhagia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "K5A6.00",
            "description": "Perimenopausal menorrhagia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Xa9CP",
            "description": "Perimenopausal menorrhagia",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE0ep",
            "description": "Puberty bleeding",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE0ew",
            "description": "Premenopausal menorrhagia",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/r1d8-5g72",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9454,
        "version_name": "Menorrhagia and polymenorrhoea",
        "version_date": "2026-06-08T20:12:59.804699Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]