[ { "phenotype_id": "PH424", "phenotype_version_id": 848, "name": "Hypothyroidism", "definition": "Patient level data were extracted from the General Practice Research Database (GPRD), which contains anonymised, patient based data on morbidity, prescribing, treatment, and referral collected from over 500 general practices, covering about 7% of the UK population (4.4 million patients).14 Data are in Read code format—a hierarchical system used to code clinical data. Additional data on prescriptions and test results are available as free-text entries. We selected a sample of 148 practices that provided data to the GPRD continuously between January 2000 and December 2007, structured to include a range of list (patient panel) sizes. Selected practices were nationally representative in terms of patient sex and age distribution and area socioeconomic deprivation but had a relatively large average list size, reflecting a bias towards larger practices in the GPRD. Overall, the selected practices performed marginally better than national practices on the clinical indicators in the Quality and Outcomes Framework. A random selection of 4500 patients registered for at least one day between 1 January 2000 and 31 December 2007 was drawn from each practice. For practices with fewer than 4501 patients, all patients were selected. The final sample consisted of 653 500 patients. Patients with relevant conditions were identified from their diagnostic Read codes. Patients for whom targets were met were identified from the relevant Read codes and free-text terms.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves, Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework. BMJ, 342:d3590, 2011." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:18:54.614615Z", "author": "Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:18:54.614644Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 }, { "name": "OXMIS codes", "value": 15 } ], "event_date_range": "01/01/2000 - 31/12/2007", "concept_information": [ { "concept_id": 1774, "concept_version_id": 4686, "concept_name": "Hypothyroidism - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH424", "phenotype_version_id": 848, "phenotype_name": "Hypothyroidism", "code_attribute_header": [ "Entity type", "Coding System (OXMIS Read)", "Category" ], "codes": [ { "code": "C03..00", "description": "Congenital hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C03y.00", "description": "Other specified congenital hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C03y000", "description": "Congenital hypothyroidism with diffuse goitre", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C03y100", "description": "Congenital hypothyroidism without goitre", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C03z.00", "description": "Congenital hypothyroidism NOS", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04..00", "description": "Acquired hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C040.00", "description": "Postsurgical hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C040.11", "description": "Post ablative hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C041.00", "description": "Other postablative hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C041000", "description": "Irradiation hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04..11", "description": "Myxoedema", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04..12", "description": "Thyroid deficiency", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04..13", "description": "Hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C041z00", "description": "Postablative hypothyroidism NOS", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C042.00", "description": "Iodine hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C043.00", "description": "Other iatrogenic hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C043000", "description": "Hypothyroidism resulting from para-aminosalicylic acid", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C043100", "description": "Hypothyroidism resulting from phenylbutazone", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C043200", "description": "Hypothyroidism resulting from resorcinol", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C043z00", "description": "Iatrogenic hypothyroidism NOS", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C044.00", "description": "Postinfectious hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C045.00", "description": "Acquired atrophy of thyroid", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C046.00", "description": "Autoimmune myxoedema", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04y.00", "description": "Other acquired hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04z.00", "description": "Hypothyroidism NOS", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04z000", "description": "Premature puberty due to hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04z100", "description": "Myxoedema coma", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04z.11", "description": "Pretibial myxoedema - hypothyroid", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04z.12", "description": "Thyroid insufficiency", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "C04z.13", "description": "Hypothyroid goitre; acquired", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "Cyu1100", "description": "[X]Other sp cified hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "F381400", "description": "Myasthenic syndrome due to hypothyroidism", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "f921.00", "description": "THYROXINE", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "f922.00", "description": "THYROXINE tabs 50micrograms", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "f923.00", "description": "THYROXINE tabs 100micrograms", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } } ] }, { "concept_id": 1775, "concept_version_id": 4688, "concept_name": "Hypothyroidism - Primary Care", "coding_system": { "id": 15, "name": "OXMIS codes", "description": "OXMIS codes" }, "phenotype_id": "PH424", "phenotype_version_id": 848, "phenotype_name": "Hypothyroidism", "code_attribute_header": [ "Entity type", "Coding System (OXMIS Read)", "Category" ], "codes": [ { "code": "243", "description": "HYPOTHYROIDISM CONGENITAL", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } }, { "code": "244 AC", "description": "HYPOTHYROIDISM ACQUIRED", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } }, { "code": "244 AG", "description": "HYPOTHYROIDISM COMPENSATED", "attributes": { "Entity type": "hypothyroidism", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/d8q7-6534", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 848, "version_name": "Hypothyroidism", "version_date": "2021-10-06T16:18:54.636104Z", "is_published": true, "is_latest": true } ] } ]