[ { "phenotype_id": "PH4244", "phenotype_version_id": 9462, "name": "Myocardial infarction", "definition": "Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:13:22.890362Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:13:22.883066Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Myocardial infarction (disorder)", "value": 598222 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "UKBioBank codes", "value": 12 }, { "name": "Non-standard codes", "value": 13 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 10504, "concept_version_id": 17989, "concept_name": "Vascular/heart problems diagnosed by doctor", "coding_system": { "id": 13, "name": "Non-standard codes", "description": "Non-standard codes" }, "phenotype_id": "PH4244", "phenotype_version_id": 9462, "phenotype_name": "Myocardial infarction", "code_attribute_header": [ "type" ], "codes": [ { "code": "1", "description": "heart attack", "attributes": { "type": "any" } } ] }, { "concept_id": 10505, "concept_version_id": 17990, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4244", "phenotype_version_id": 9462, "phenotype_name": "Myocardial infarction", "code_attribute_header": [ "type" ], "codes": [ { "code": "1075", "description": "heart attack/myocardial infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 10506, "concept_version_id": 17991, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4244", "phenotype_version_id": 9462, "phenotype_name": "Myocardial infarction", "code_attribute_header": [ "type" ], "codes": [ { "code": "I21", "description": "Acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "I22", "description": "Subsequent myocardial infarction", "attributes": { "type": "any" } }, { "code": "I23", "description": "Certain current complications following acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "I24.1", "description": "Dressler's syndrome", "attributes": { "type": "any" } }, { "code": "I25.2", "description": "Old myocardial infarction", "attributes": { "type": "prevalent" } } ] }, { "concept_id": 10507, "concept_version_id": 17992, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4244", "phenotype_version_id": 9462, "phenotype_name": "Myocardial infarction", "code_attribute_header": [ "type" ], "codes": [ { "code": "I21", "description": "Acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "I22", "description": "Subsequent myocardial infarction", "attributes": { "type": "prevalent" } }, { "code": "I23", "description": "Certain current complications following acute myocardial infarction", "attributes": { "type": "prevalent" } }, { "code": "I24.1", "description": "Dressler's syndrome", "attributes": { "type": "any" } }, { "code": "I25.2", "description": "Old myocardial infarction", "attributes": { "type": "prevalent" } } ] }, { "concept_id": 10508, "concept_version_id": 17993, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4244", "phenotype_version_id": 9462, "phenotype_name": "Myocardial infarction", "code_attribute_header": [ "type" ], "codes": [ { "code": "I21", "description": "Acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "I22", "description": "Subsequent myocardial infarction", "attributes": { "type": "any" } }, { "code": "I23", "description": "Certain current complications following acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "I24.1", "description": "Dressler's syndrome", "attributes": { "type": "any" } }, { "code": "I25.2", "description": "Old myocardial infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 10509, "concept_version_id": 17994, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4244", "phenotype_version_id": 9462, "phenotype_name": "Myocardial infarction", "code_attribute_header": [ "type" ], "codes": [ { "code": "I21", "description": "Acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "I22", "description": "Subsequent myocardial infarction", "attributes": { "type": "any" } }, { "code": "I23", "description": "Certain current complications following acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "I24.1", "description": "Dressler's syndrome", "attributes": { "type": "any" } }, { "code": "I25.2", "description": "Old myocardial infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 10510, "concept_version_id": 17995, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4244", "phenotype_version_id": 9462, "phenotype_name": "Myocardial infarction", "code_attribute_header": [ "type" ], "codes": [ { "code": "14A3.00", "description": "H/O: myocardial infarct <60", "attributes": { "type": "prevalent" } }, { "code": "14A4.00", "description": "H/O: myocardial infarct >60", "attributes": { "type": "prevalent" } }, { "code": "14AH.00", "description": "H/O: Myocardial infarction in last year", "attributes": { "type": "prevalent" } }, { "code": "323..00", "description": "ECG: myocardial infarction", "attributes": { "type": "any" } }, { "code": "3233", "description": "ECG: antero-septal infarct.", "attributes": { "type": "any" } }, { "code": "3234", "description": "ECG:posterior/inferior infarct", "attributes": { "type": "any" } }, { "code": "3235", "description": "ECG: subendocardial infarct", "attributes": { "type": "any" } }, { "code": "3236", "description": "ECG: lateral infarction", "attributes": { "type": "any" } }, { "code": "323Z.00", "description": "ECG: myocardial infarct NOS", "attributes": { "type": "any" } }, { "code": "889A.00", "description": "Diab mellit insulin-glucose infus acute myocardial infarct", "attributes": { "type": "any" } }, { "code": "G30..00", "description": "Acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "G300.00", "description": "Acute anterolateral infarction", "attributes": { "type": "any" } }, { "code": "G301.00", "description": "Other specified anterior myocardial infarction", "attributes": { "type": "any" } }, { "code": "G301000", "description": "Acute anteroapical infarction", "attributes": { "type": "any" } }, { "code": "G30..11", "description": "Attack - heart", "attributes": { "type": "any" } }, { "code": "G301100", "description": "Acute anteroseptal infarction", "attributes": { "type": "any" } }, { "code": "G30..12", "description": "Coronary thrombosis", "attributes": { "type": "any" } }, { "code": "G30..13", "description": "Cardiac rupture following myocardial infarction (MI)", "attributes": { "type": "any" } }, { "code": "G30..14", "description": "Heart attack", "attributes": { "type": "any" } }, { "code": "G30..15", "description": "MI - acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "G30..16", "description": "Thrombosis - coronary", "attributes": { "type": "any" } }, { "code": "G30..17", "description": "Silent myocardial infarction", "attributes": { "type": "any" } }, { "code": "G301z00", "description": "Anterior myocardial infarction NOS", "attributes": { "type": "any" } }, { "code": "G302.00", "description": "Acute inferolateral infarction", "attributes": { "type": "any" } }, { "code": "G303.00", "description": "Acute inferoposterior infarction", "attributes": { "type": "any" } }, { "code": "G304.00", "description": "Posterior myocardial infarction NOS", "attributes": { "type": "any" } }, { "code": "G305.00", "description": "Lateral myocardial infarction NOS", "attributes": { "type": "any" } }, { "code": "G306.00", "description": "True posterior myocardial infarction", "attributes": { "type": "any" } }, { "code": "G307.00", "description": "Acute subendocardial infarction", "attributes": { "type": "any" } }, { "code": "G307000", "description": "Acute non-Q wave infarction", "attributes": { "type": "any" } }, { "code": "G307100", "description": "Acute non-ST segment elevation myocardial infarction", "attributes": { "type": "any" } }, { "code": "G308.00", "description": "Inferior myocardial infarction NOS", "attributes": { "type": "any" } }, { "code": "G309.00", "description": "Acute Q-wave infarct", "attributes": { "type": "any" } }, { "code": "G30A.00", "description": "Mural thrombosis", "attributes": { "type": "any" } }, { "code": "G30B.00", "description": "Acute posterolateral myocardial infarction", "attributes": { "type": "any" } }, { "code": "G30X.00", "description": "Acute transmural myocardial infarction of unspecif site", "attributes": { "type": "any" } }, { "code": "G30X000", "description": "Acute ST segment elevation myocardial infarction", "attributes": { "type": "any" } }, { "code": "G30y.00", "description": "Other acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "G30y000", "description": "Acute atrial infarction", "attributes": { "type": "any" } }, { "code": "G30y100", "description": "Acute papillary muscle infarction", "attributes": { "type": "any" } }, { "code": "G30y200", "description": "Acute septal infarction", "attributes": { "type": "any" } }, { "code": "G30yz00", "description": "Other acute myocardial infarction NOS", "attributes": { "type": "any" } }, { "code": "G30z.00", "description": "Acute myocardial infarction NOS", "attributes": { "type": "any" } }, { "code": "G310.00", "description": "Postmyocardial infarction syndrome", "attributes": { "type": "any" } }, { "code": "G310.11", "description": "Dressler's syndrome", "attributes": { "type": "any" } }, { "code": "G31y100", "description": "Microinfarction of heart", "attributes": { "type": "any" } }, { "code": "G32..00", "description": "Old myocardial infarction", "attributes": { "type": "prevalent" } }, { "code": "G32..11", "description": "Healed myocardial infarction", "attributes": { "type": "prevalent" } }, { "code": "G32..12", "description": "Personal history of myocardial infarction", "attributes": { "type": "prevalent" } }, { "code": "G33z500", "description": "Post infarct angina", "attributes": { "type": "prevalent" } }, { "code": "G35..00", "description": "Subsequent myocardial infarction", "attributes": { "type": "any" } }, { "code": "G350.00", "description": "Subsequent myocardial infarction of anterior wall", "attributes": { "type": "any" } }, { "code": "G351.00", "description": "Subsequent myocardial infarction of inferior wall", "attributes": { "type": "any" } }, { "code": "G353.00", "description": "Subsequent myocardial infarction of other sites", "attributes": { "type": "any" } }, { "code": "G35X.00", "description": "Subsequent myocardial infarction of unspecified site", "attributes": { "type": "any" } }, { "code": "G36..00", "description": "Certain current complication follow acute myocardial infarct", "attributes": { "type": "any" } }, { "code": "G360.00", "description": "Haemopericardium/current comp folow acut myocard infarct", "attributes": { "type": "any" } }, { "code": "G361.00", "description": "Atrial septal defect/curr comp folow acut myocardal infarct", "attributes": { "type": "any" } }, { "code": "G362.00", "description": "Ventric septal defect/curr comp fol acut myocardal infarctn", "attributes": { "type": "any" } }, { "code": "G363.00", "description": "Ruptur cardiac wall w'out haemopericard/cur comp fol ac MI", "attributes": { "type": "any" } }, { "code": "G364.00", "description": "Ruptur chordae tendinae/curr comp fol acute myocard infarct", "attributes": { "type": "any" } }, { "code": "G365.00", "description": "Rupture papillary muscle/curr comp fol acute myocard infarct", "attributes": { "type": "any" } }, { "code": "G366.00", "description": "Thrombosis atrium,auric append&vent/curr comp foll acute MI", "attributes": { "type": "any" } }, { "code": "G38..00", "description": "Postoperative myocardial infarction", "attributes": { "type": "any" } }, { "code": "G380.00", "description": "Postoperative transmural myocardial infarction anterior wall", "attributes": { "type": "any" } }, { "code": "G381.00", "description": "Postoperative transmural myocardial infarction inferior wall", "attributes": { "type": "any" } }, { "code": "G384.00", "description": "Postoperative subendocardial myocardial infarction", "attributes": { "type": "any" } }, { "code": "G38z.00", "description": "Postoperative myocardial infarction, unspecified", "attributes": { "type": "any" } }, { "code": "G501.00", "description": "Post infarction pericarditis", "attributes": { "type": "any" } }, { "code": "Gyu3400", "description": "[X]Acute transmural myocardial infarction of unspecif site", "attributes": { "type": "any" } }, { "code": "XaAzi", "description": "Acute non-Q wave infarction", "attributes": { "type": "any" } }, { "code": "XaBL1", "description": "H/O: Myocardial infarction in last year", "attributes": { "type": "prevalent" } }, { "code": "XaD2b", "description": "Postoperative myocardial infarction", "attributes": { "type": "any" } }, { "code": "XaD2d", "description": "Postoperative transmural myocardial infarction of anterior wall", "attributes": { "type": "any" } }, { "code": "XaD2e", "description": "Postoperative transmural myocardial infarction of inferior wall", "attributes": { "type": "any" } }, { "code": "XaD2h", "description": "Postoperative subendocardial myocardial infarction", "attributes": { "type": "any" } }, { "code": "XaD2i", "description": "Postoperative myocardial infarction, unspecified", "attributes": { "type": "any" } }, { "code": "XaEXt", "description": "Post infarct angina", "attributes": { "type": "any" } }, { "code": "XaFx7", "description": "Diabetes mellitus insulin-glucose infusion in acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "XaIwM", "description": "Acute ST segment elevation myocardial infarction", "attributes": { "type": "any" } }, { "code": "XaIwY", "description": "Acute non-ST segment elevation myocardial infarction", "attributes": { "type": "any" } }, { "code": "XaJX0", "description": "Acute posterolateral myocardial infarction", "attributes": { "type": "any" } }, { "code": "XE0Uh", "description": "Acute myocardial infarction", "attributes": { "type": "any" } }, { "code": "XE2aA", "description": "Old myocardial infarction", "attributes": { "type": "prevalent" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/gq97-1588", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9462, "version_name": "Myocardial infarction", "version_date": "2026-06-08T20:13:22.898750Z", "is_published": true, "is_latest": true } ] } ]