[
  {
    "phenotype_id": "PH4245",
    "phenotype_version_id": 9463,
    "name": "Nasal polyp",
    "definition": "Nasal polyps are soft, painless, noncancerous growths on the lining of the nasal passages or sinuses\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:13:25.838579Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:13:25.829578Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Polyp of nasal sinus (disorder)",
        "value": 785021
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      },
      {
        "name": "OPCS4 codes",
        "value": 7
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10511,
        "concept_version_id": 17996,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4245",
        "phenotype_version_id": 9463,
        "phenotype_name": "Nasal polyp",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1417",
            "description": "nasal polyps",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10512,
        "concept_version_id": 17997,
        "concept_name": "Operation code",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4245",
        "phenotype_version_id": 9463,
        "phenotype_name": "Nasal polyp",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1559",
            "description": "nasal polyp surgery / nasal polypectomy",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10513,
        "concept_version_id": 17998,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4245",
        "phenotype_version_id": 9463,
        "phenotype_name": "Nasal polyp",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "J33",
            "description": "Nasal polyp",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10514,
        "concept_version_id": 17999,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4245",
        "phenotype_version_id": 9463,
        "phenotype_name": "Nasal polyp",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "J33",
            "description": "Nasal polyp",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10515,
        "concept_version_id": 18000,
        "concept_name": "Operative procedures - main OPCS4",
        "coding_system": {
          "id": 7,
          "name": "OPCS4 codes",
          "description": "OPCS4 codes"
        },
        "phenotype_id": "PH4245",
        "phenotype_version_id": 9463,
        "phenotype_name": "Nasal polyp",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E08.1",
            "description": "Polypectomy of internal nose",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10516,
        "concept_version_id": 18001,
        "concept_name": "Operative procedures - secondary OPCS4",
        "coding_system": {
          "id": 7,
          "name": "OPCS4 codes",
          "description": "OPCS4 codes"
        },
        "phenotype_id": "PH4245",
        "phenotype_version_id": 9463,
        "phenotype_name": "Nasal polyp",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E08.1",
            "description": "Polypectomy of internal nose",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10517,
        "concept_version_id": 18002,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4245",
        "phenotype_version_id": 9463,
        "phenotype_name": "Nasal polyp",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "J33",
            "description": "Nasal polyp",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10518,
        "concept_version_id": 18003,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4245",
        "phenotype_version_id": 9463,
        "phenotype_name": "Nasal polyp",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "J33",
            "description": "Nasal polyp",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10519,
        "concept_version_id": 18004,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4245",
        "phenotype_version_id": 9463,
        "phenotype_name": "Nasal polyp",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "2D33.00",
            "description": "O/E - nasal polyp present",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7402900.0",
            "description": "Excision of polyp of nasal septum",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7402911.0",
            "description": "Nasal septum polypectomy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7406000.0",
            "description": "Nasal polypectomy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7406700.0",
            "description": "Nasal polypectomy using auto-debrider",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7416F00",
            "description": "Functional endoscopic sinus surg - polypectomy nasal sinus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H11..00",
            "description": "Nasal polyps",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H110.00",
            "description": "Polyp of nasal cavity",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H110000",
            "description": "Choanal polyp",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H110100",
            "description": "Nasopharyngeal polyp",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H110z00",
            "description": "Polyp of nasal cavity NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H111.00",
            "description": "Polypoid sinus degeneration",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H111000",
            "description": "Woakes' ethmoiditis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H111z00",
            "description": "Polypoid sinus degeneration NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H11y.00",
            "description": "Other polyp of sinus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H11y000",
            "description": "Polyp of frontal sinus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H11y100",
            "description": "Polyp of ethmoidal sinus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H11y.11",
            "description": "Nasal sinus polyps",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H11y200",
            "description": "Polyp of maxillary sinus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H11y211",
            "description": "Antral (maxillary) polyp",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H11y300",
            "description": "Polyp of sphenoidal sinus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H11yz00",
            "description": "Other polyp of sinus NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H11z.00",
            "description": "Nasal polyp NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Hyu2300",
            "description": "[X]Other polyp of sinus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaDyR",
            "description": "Nasal polypectomy using auto-debrider",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaIwR",
            "description": "Functional endoscopic sinus surgery - polypectomy of nasal sinus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE0Xv",
            "description": "Other polyp of sinus",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/wghc-q139",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9463,
        "version_name": "Nasal polyp",
        "version_date": "2026-06-08T20:13:25.851315Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]