[ { "phenotype_id": "PH4252", "phenotype_version_id": 9470, "name": "Obesity", "definition": "Obesity is a complex disease involving an excessive amount of body fat.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:13:48.594216Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:13:48.588289Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Obesity (disorder)", "value": 352027 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 }, { "name": "OPCS4 codes", "value": 7 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 10555, "concept_version_id": 18040, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4252", "phenotype_version_id": 9470, "phenotype_name": "Obesity", "code_attribute_header": [ "type" ], "codes": [ { "code": "E66", "description": "Obesity", "attributes": { "type": "any" } } ] }, { "concept_id": 10556, "concept_version_id": 18041, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4252", "phenotype_version_id": 9470, "phenotype_name": "Obesity", "code_attribute_header": [ "type" ], "codes": [ { "code": "E66", "description": "Obesity", "attributes": { "type": "any" } } ] }, { "concept_id": 10557, "concept_version_id": 18042, "concept_name": "Operative procedures - main OPCS4", "coding_system": { "id": 7, "name": "OPCS4 codes", "description": "OPCS4 codes" }, "phenotype_id": "PH4252", "phenotype_version_id": 9470, "phenotype_name": "Obesity", "code_attribute_header": [ "type" ], "codes": [ { "code": "G282", "description": "G282", "attributes": { "type": "any" } }, { "code": "G283", "description": "G283", "attributes": { "type": "any" } }, { "code": "G288", "description": "G288", "attributes": { "type": "any" } }, { "code": "G289", "description": "G289", "attributes": { "type": "any" } }, { "code": "G301", "description": "G301", "attributes": { "type": "any" } }, { "code": "G302", "description": "G302", "attributes": { "type": "any" } }, { "code": "G303", "description": "G303", "attributes": { "type": "any" } }, { "code": "G304", "description": "G304", "attributes": { "type": "any" } }, { "code": "G308", "description": "G308", "attributes": { "type": "any" } }, { "code": "G309", "description": "G309", "attributes": { "type": "any" } }, { "code": "G321", "description": "G321", "attributes": { "type": "any" } }, { "code": "G328", "description": "G328", "attributes": { "type": "any" } }, { "code": "G329", "description": "G329", "attributes": { "type": "any" } }, { "code": "G611", "description": "G611", "attributes": { "type": "any" } }, { "code": "G612", "description": "G612", "attributes": { "type": "any" } }, { "code": "G613", "description": "G613", "attributes": { "type": "any" } }, { "code": "G618", "description": "G618", "attributes": { "type": "any" } }, { "code": "G619", "description": "G619", "attributes": { "type": "any" } } ] }, { "concept_id": 10558, "concept_version_id": 18043, "concept_name": "Operative procedures - secondary OPCS4", "coding_system": { "id": 7, "name": "OPCS4 codes", "description": "OPCS4 codes" }, "phenotype_id": "PH4252", "phenotype_version_id": 9470, "phenotype_name": "Obesity", "code_attribute_header": [ "type" ], "codes": [ { "code": "G282", "description": "G282", "attributes": { "type": "any" } }, { "code": "G283", "description": "G283", "attributes": { "type": "any" } }, { "code": "G288", "description": "G288", "attributes": { "type": "any" } }, { "code": "G289", "description": "G289", "attributes": { "type": "any" } }, { "code": "G301", "description": "G301", "attributes": { "type": "any" } }, { "code": "G302", "description": "G302", "attributes": { "type": "any" } }, { "code": "G303", "description": "G303", "attributes": { "type": "any" } }, { "code": "G304", "description": "G304", "attributes": { "type": "any" } }, { "code": "G308", "description": "G308", "attributes": { "type": "any" } }, { "code": "G309", "description": "G309", "attributes": { "type": "any" } }, { "code": "G321", "description": "G321", "attributes": { "type": "any" } }, { "code": "G328", "description": "G328", "attributes": { "type": "any" } }, { "code": "G329", "description": "G329", "attributes": { "type": "any" } }, { "code": "G611", "description": "G611", "attributes": { "type": "any" } }, { "code": "G612", "description": "G612", "attributes": { "type": "any" } }, { "code": "G613", "description": "G613", "attributes": { "type": "any" } }, { "code": "G618", "description": "G618", "attributes": { "type": "any" } }, { "code": "G619", "description": "G619", "attributes": { "type": "any" } } ] }, { "concept_id": 10559, "concept_version_id": 18044, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4252", "phenotype_version_id": 9470, "phenotype_name": "Obesity", "code_attribute_header": [ "type" ], "codes": [ { "code": "E66", "description": "Obesity", "attributes": { "type": "any" } } ] }, { "concept_id": 10560, "concept_version_id": 18045, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4252", "phenotype_version_id": 9470, "phenotype_name": "Obesity", "code_attribute_header": [ "type" ], "codes": [ { "code": "E66", "description": "Obesity", "attributes": { "type": "any" } } ] }, { "concept_id": 10561, "concept_version_id": 18046, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4252", "phenotype_version_id": 9470, "phenotype_name": "Obesity", "code_attribute_header": [ "type" ], "codes": [ { "code": "1444.00", "description": "H/O: obesity", "attributes": { "type": "prevalent" } }, { "code": "212Q.00", "description": "Obesity resolved", "attributes": { "type": "any" } }, { "code": "222A.00", "description": "O/E - obese", "attributes": { "type": "any" } }, { "code": "22A5.11", "description": "O/E - obese", "attributes": { "type": "any" } }, { "code": "22K5.00", "description": "Body mass index 30+ - obesity", "attributes": { "type": "any" } }, { "code": "22K7.00", "description": "Body mass index 40+ - severely obese", "attributes": { "type": "any" } }, { "code": "66C..00", "description": "Obesity monitoring", "attributes": { "type": "prevalent" } }, { "code": "66C1.00", "description": "Initial obesity assessment", "attributes": { "type": "any" } }, { "code": "66C2.00", "description": "Follow-up obesity assessment", "attributes": { "type": "prevalent" } }, { "code": "66C4.00", "description": "Has seen dietician - obesity", "attributes": { "type": "any" } }, { "code": "66C5.00", "description": "Treatment of obesity changed", "attributes": { "type": "any" } }, { "code": "66C6.00", "description": "Treatment of obesity started", "attributes": { "type": "any" } }, { "code": "66CE.00", "description": "Reason for obesity therapy - occupational", "attributes": { "type": "any" } }, { "code": "66CZ.00", "description": "Obesity monitoring NOS", "attributes": { "type": "prevalent" } }, { "code": "7611400.0", "description": "Sleeve gastrectomy and duodenal switch", "attributes": { "type": "any" } }, { "code": "7611500.0", "description": "Sleeve gastrectomy NEC", "attributes": { "type": "any" } }, { "code": "7611600.0", "description": "Laparoscopic sleeve gastrectomy", "attributes": { "type": "any" } }, { "code": "7613100.0", "description": "Partitioning of stomach", "attributes": { "type": "any" } }, { "code": "7613111.0", "description": "Mason vertical banded gastroplasty", "attributes": { "type": "any" } }, { "code": "7613200.0", "description": "Laparoscopic adjustable gastric banding", "attributes": { "type": "any" } }, { "code": "7613300.0", "description": "Partitioning of stomach using band", "attributes": { "type": "any" } }, { "code": "7613400.0", "description": "Partitioning of stomach using staples", "attributes": { "type": "any" } }, { "code": "7613500.0", "description": "Partitioning of stomach NEC", "attributes": { "type": "any" } }, { "code": "7613600.0", "description": "Maintenance of gastric band", "attributes": { "type": "any" } }, { "code": "7614100.0", "description": "Bypass of stomach by anastomosis of stomach to duodenum", "attributes": { "type": "any" } }, { "code": "7615000.0", "description": "Bypass stomach by anastomosis stomach to transposed jejunum", "attributes": { "type": "any" } }, { "code": "7616000.0", "description": "Bypass of stomach by anastomosis of stomach to jejunum NEC", "attributes": { "type": "any" } }, { "code": "7616013.0", "description": "Mason high gastric bypass", "attributes": { "type": "any" } }, { "code": "7616015.0", "description": "Printer high gastric bypass", "attributes": { "type": "any" } }, { "code": "7616600.0", "description": "Laparoscopic gastric bypass", "attributes": { "type": "any" } }, { "code": "761A500", "description": "Removal of gastric band", "attributes": { "type": "any" } }, { "code": "7633.00", "description": "Bypass of jejunum", "attributes": { "type": "any" } }, { "code": "7633000.0", "description": "Bypass of jejunum by anastomosis of jejunum to jejunum", "attributes": { "type": "any" } }, { "code": "7633100.0", "description": "Bypass of jejunum by anastomosis of jejunum to ileum", "attributes": { "type": "any" } }, { "code": "7633200.0", "description": "Bypass of jejunum by anastomosis of jejunum to colon", "attributes": { "type": "any" } }, { "code": "7633y00", "description": "Other specified bypass of jejunum", "attributes": { "type": "any" } }, { "code": "7633z00", "description": "Bypass of jejunum NOS", "attributes": { "type": "any" } }, { "code": "7642500.0", "description": "Duodenal switch", "attributes": { "type": "any" } }, { "code": "9OK..00", "description": "Obesity monitoring admin.", "attributes": { "type": "prevalent" } }, { "code": "9OK1.00", "description": "Attends obesity monitoring", "attributes": { "type": "prevalent" } }, { "code": "9OK..11", "description": "Obesity clinic administration", "attributes": { "type": "any" } }, { "code": "9OK2.00", "description": "Refuses obesity monitoring", "attributes": { "type": "prevalent" } }, { "code": "9OK3.00", "description": "Obesity monitoring default", "attributes": { "type": "prevalent" } }, { "code": "9OK4.00", "description": "Obesity monitoring 1st letter", "attributes": { "type": "prevalent" } }, { "code": "9OK5.00", "description": "Obesity monitoring 2nd letter", "attributes": { "type": "prevalent" } }, { "code": "9OK6.00", "description": "Obesity monitoring 3rd letter", "attributes": { "type": "prevalent" } }, { "code": "9OK7.00", "description": "Obesity monitoring verbal inv.", "attributes": { "type": "prevalent" } }, { "code": "9OK8.00", "description": "Obesity monitor phone invite", "attributes": { "type": "any" } }, { "code": "9OKA.00", "description": "Obesity monitoring check done", "attributes": { "type": "prevalent" } }, { "code": "9OKZ.00", "description": "Obesity monitoring admin.NOS", "attributes": { "type": "prevalent" } }, { "code": "C38..00", "description": "Obesity and other hyperalimentation", "attributes": { "type": "any" } }, { "code": "C380.00", "description": "Obesity", "attributes": { "type": "any" } }, { "code": "C380000", "description": "Obesity due to excess calories", "attributes": { "type": "any" } }, { "code": "C380100", "description": "Drug-induced obesity", "attributes": { "type": "any" } }, { "code": "C380200", "description": "Extreme obesity with alveolar hypoventilation", "attributes": { "type": "any" } }, { "code": "C380300", "description": "Morbid obesity", "attributes": { "type": "any" } }, { "code": "C380400", "description": "Central obesity", "attributes": { "type": "any" } }, { "code": "C380500", "description": "Generalised obesity", "attributes": { "type": "any" } }, { "code": "C380600", "description": "Adult-onset obesity", "attributes": { "type": "any" } }, { "code": "C380700", "description": "Lifelong obesity", "attributes": { "type": "any" } }, { "code": "C38y000", "description": "Pickwickian syndrome", "attributes": { "type": "any" } }, { "code": "C38y011", "description": "Obesity hypoventilation syndrome", "attributes": { "type": "any" } }, { "code": "C38y.11", "description": "Pickwickian syndrome", "attributes": { "type": "any" } }, { "code": "C38z.00", "description": "Obesity and other hyperalimentation NOS", "attributes": { "type": "any" } }, { "code": "C38z000", "description": "Simple obesity NOS", "attributes": { "type": "any" } }, { "code": "Cyu7.00", "description": "[X]Obesity and other hyperalimentation", "attributes": { "type": "any" } }, { "code": "Cyu7000", "description": "[X]Other obesity", "attributes": { "type": "any" } }, { "code": "X40YO", "description": "Generalised obesity", "attributes": { "type": "any" } }, { "code": "X40YQ", "description": "Morbid obesity", "attributes": { "type": "any" } }, { "code": "X40YR", "description": "Pickwickian syndrome", "attributes": { "type": "any" } }, { "code": "X76BU", "description": "Central obesity", "attributes": { "type": "any" } }, { "code": "XaBM0", "description": "Simple obesity NOS", "attributes": { "type": "any" } }, { "code": "XaJJH", "description": "Body mass index 40+ - severely obese", "attributes": { "type": "any" } }, { "code": "XaK95", "description": "Laparoscopic adjustable gastric banding", "attributes": { "type": "any" } }, { "code": "XaKko", "description": "Obesity resolved", "attributes": { "type": "any" } }, { "code": "XaLd7", "description": "Sleeve gastrectomy and duodenal switch", "attributes": { "type": "any" } }, { "code": "XaLd8", "description": "Sleeve gastrectomy NEC", "attributes": { "type": "any" } }, { "code": "XaLd9", "description": "Partitioning of stomach using band", "attributes": { "type": "any" } }, { "code": "XaLdA", "description": "Partitioning of stomach using staples", "attributes": { "type": "any" } }, { "code": "XaLdH", "description": "Removal of gastric band", "attributes": { "type": "any" } }, { "code": "XaLdW", "description": "Duodenal switch", "attributes": { "type": "any" } }, { "code": "XaMgn", "description": "Laparoscopic sleeve gastrectomy", "attributes": { "type": "any" } }, { "code": "XaMHV", "description": "Partitioning of stomach NEC", "attributes": { "type": "any" } }, { "code": "XaOi9", "description": "Laparoscopic gastric bypass", "attributes": { "type": "any" } }, { "code": "XaPp5", "description": "[V]Presence of gastric bypass", "attributes": { "type": "any" } }, { "code": "XaPpT", "description": "Maintenance of gastric band", "attributes": { "type": "any" } }, { "code": "XE0Cg", "description": "Partitioning of stomach", "attributes": { "type": "any" } }, { "code": "XE0Ch", "description": "Bypass of stomach by anastomosis of stomach to duodenum", "attributes": { "type": "any" } }, { "code": "XE0Ci", "description": "Bypass of stomach by anastomosis of stomach to jejunum NEC", "attributes": { "type": "any" } }, { "code": "XE0Cy", "description": "Bypass of jejunum by anastomosis of jejunum to colon", "attributes": { "type": "any" } }, { "code": "XE11t", "description": "Other hyperalimentation", "attributes": { "type": "any" } }, { "code": "XE1T6", "description": "Obesity monitoring", "attributes": { "type": "prevalent" } }, { "code": "XE2Nc", "description": "Obesity monitoring admin.", "attributes": { "type": "prevalent" } }, { "code": "XSCIX", "description": "Lifelong obesity", "attributes": { "type": "any" } }, { "code": "XSCIZ", "description": "Adult-onset obesity", "attributes": { "type": "any" } }, { "code": "ZC2CM00", "description": "Dietary advice for obesity", "attributes": { "type": "any" } }, { "code": "ZV45P00", "description": "[V]Presence of gastric bypass", "attributes": { "type": "any" } }, { "code": "ZV65319", "description": "[V]Dietary counselling in obesity", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/rpp0-9655", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9470, "version_name": "Obesity", "version_date": "2026-06-08T20:13:48.605362Z", "is_published": true, "is_latest": true } ] } ]