[ { "phenotype_id": "PH4253", "phenotype_version_id": 9471, "name": "Obstructive and reflux uropathy", "definition": "Obstructive uropathy: a structural or functional hindrance of normal urine flow. Reflux uropathy: a condition in which urine regurgitates from the bladder back into the ureter.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:13:51.586361Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:13:51.580546Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Urinary tract obstruction (disorder)", "value": 335933 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 10562, "concept_version_id": 18047, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4253", "phenotype_version_id": 9471, "phenotype_name": "Obstructive and reflux uropathy", "code_attribute_header": [ "type" ], "codes": [ { "code": "N13.0", "description": "Hydronephrosis with ureteropelvic junction obstruction", "attributes": { "type": "any" } }, { "code": "N13.1", "description": "Hydronephrosis with ureteral stricture, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "N13.2", "description": "Hydronephrosis with renal and ureteral calculous obstruction", "attributes": { "type": "any" } }, { "code": "N13.3", "description": "Other and unspecified hydronephrosis", "attributes": { "type": "any" } }, { "code": "N13.4", "description": "Hydroureter", "attributes": { "type": "any" } }, { "code": "N13.5", "description": "Kinking and stricture of ureter without hydronephrosis", "attributes": { "type": "any" } }, { "code": "N13.6", "description": "Pyonephrosis", "attributes": { "type": "any" } }, { "code": "N13.7", "description": "Vesicoureteral-reflux-associated uropathy", "attributes": { "type": "any" } }, { "code": "N13.8", "description": "Other obstructive and reflux uropathy", "attributes": { "type": "any" } }, { "code": "N13.9", "description": "Obstructive and reflux uropathy, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 10563, "concept_version_id": 18048, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4253", "phenotype_version_id": 9471, "phenotype_name": "Obstructive and reflux uropathy", "code_attribute_header": [ "type" ], "codes": [ { "code": "N13.0", "description": "Hydronephrosis with ureteropelvic junction obstruction", "attributes": { "type": "any" } }, { "code": "N13.1", "description": "Hydronephrosis with ureteral stricture, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "N13.2", "description": "Hydronephrosis with renal and ureteral calculous obstruction", "attributes": { "type": "any" } }, { "code": "N13.3", "description": "Other and unspecified hydronephrosis", "attributes": { "type": "any" } }, { "code": "N13.4", "description": "Hydroureter", "attributes": { "type": "any" } }, { "code": "N13.5", "description": "Kinking and stricture of ureter without hydronephrosis", "attributes": { "type": "any" } }, { "code": "N13.6", "description": "Pyonephrosis", "attributes": { "type": "any" } }, { "code": "N13.7", "description": "Vesicoureteral-reflux-associated uropathy", "attributes": { "type": "any" } }, { "code": "N13.8", "description": "Other obstructive and reflux uropathy", "attributes": { "type": "any" } }, { "code": "N13.9", "description": "Obstructive and reflux uropathy, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 10564, "concept_version_id": 18049, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4253", "phenotype_version_id": 9471, "phenotype_name": "Obstructive and reflux uropathy", "code_attribute_header": [ "type" ], "codes": [ { "code": "N13.0", "description": "Hydronephrosis with ureteropelvic junction obstruction", "attributes": { "type": "any" } }, { "code": "N13.1", "description": "Hydronephrosis with ureteral stricture, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "N13.2", "description": "Hydronephrosis with renal and ureteral calculous obstruction", "attributes": { "type": "any" } }, { "code": "N13.3", "description": "Other and unspecified hydronephrosis", "attributes": { "type": "any" } }, { "code": "N13.4", "description": "Hydroureter", "attributes": { "type": "any" } }, { "code": "N13.5", "description": "Kinking and stricture of ureter without hydronephrosis", "attributes": { "type": "any" } }, { "code": "N13.6", "description": "Pyonephrosis", "attributes": { "type": "any" } }, { "code": "N13.7", "description": "Vesicoureteral-reflux-associated uropathy", "attributes": { "type": "any" } }, { "code": "N13.8", "description": "Other obstructive and reflux uropathy", "attributes": { "type": "any" } }, { "code": "N13.9", "description": "Obstructive and reflux uropathy, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 10565, "concept_version_id": 18050, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4253", "phenotype_version_id": 9471, "phenotype_name": "Obstructive and reflux uropathy", "code_attribute_header": [ "type" ], "codes": [ { "code": "N13.0", "description": "Hydronephrosis with ureteropelvic junction obstruction", "attributes": { "type": "any" } }, { "code": "N13.1", "description": "Hydronephrosis with ureteral stricture, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "N13.2", "description": "Hydronephrosis with renal and ureteral calculous obstruction", "attributes": { "type": "any" } }, { "code": "N13.3", "description": "Other and unspecified hydronephrosis", "attributes": { "type": "any" } }, { "code": "N13.4", "description": "Hydroureter", "attributes": { "type": "any" } }, { "code": "N13.5", "description": "Kinking and stricture of ureter without hydronephrosis", "attributes": { "type": "any" } }, { "code": "N13.6", "description": "Pyonephrosis", "attributes": { "type": "any" } }, { "code": "N13.7", "description": "Vesicoureteral-reflux-associated uropathy", "attributes": { "type": "any" } }, { "code": "N13.8", "description": "Other obstructive and reflux uropathy", "attributes": { "type": "any" } }, { "code": "N13.9", "description": "Obstructive and reflux uropathy, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 10566, "concept_version_id": 18051, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4253", "phenotype_version_id": 9471, "phenotype_name": "Obstructive and reflux uropathy", "code_attribute_header": [ "type" ], "codes": [ { "code": "K11..00", "description": "Hydronephrosis", "attributes": { "type": "any" } }, { "code": "K110.00", "description": "Hydrocalycosis", "attributes": { "type": "any" } }, { "code": "K111.00", "description": "Hydroureteronephrosis", "attributes": { "type": "any" } }, { "code": "K112.00", "description": "Hydronephrosis with renal and ureteral calculous obstruction", "attributes": { "type": "any" } }, { "code": "K113.00", "description": "Hydronephrosis with ureteropelvic junction obstruction", "attributes": { "type": "any" } }, { "code": "K113.11", "description": "Hydronephrosis with pelviureteric junction obstruction", "attributes": { "type": "any" } }, { "code": "K11X.00", "description": "Hydronephrosis with ureteral stricture NEC", "attributes": { "type": "any" } }, { "code": "K11z.00", "description": "Hydronephrosis NOS", "attributes": { "type": "any" } }, { "code": "K133.00", "description": "Stricture of ureter", "attributes": { "type": "any" } }, { "code": "K133000", "description": "Postoperative ureteric constriction", "attributes": { "type": "any" } }, { "code": "K133100", "description": "Stricture of pelviureteric junction", "attributes": { "type": "any" } }, { "code": "K133z00", "description": "Stricture of ureter NOS", "attributes": { "type": "any" } }, { "code": "K134.00", "description": "Other ureteric obstruction", "attributes": { "type": "any" } }, { "code": "K134000", "description": "Idiopathic retroperitoneal fibrosis", "attributes": { "type": "any" } }, { "code": "K134z00", "description": "Occlusion of ureter NOS", "attributes": { "type": "any" } }, { "code": "K135.00", "description": "Hydroureter", "attributes": { "type": "any" } }, { "code": "K137.00", "description": "Vesicoureteric reflux", "attributes": { "type": "any" } }, { "code": "K137.11", "description": "Ureteric reflux", "attributes": { "type": "any" } }, { "code": "K196.00", "description": "Urinary obstruction unspecified", "attributes": { "type": "any" } }, { "code": "K196.11", "description": "Obstructive uropathy, unspecified", "attributes": { "type": "any" } }, { "code": "Kyu1100", "description": "[X]Other and unspecified hydronephrosis", "attributes": { "type": "any" } }, { "code": "Kyu1200", "description": "[X]Other obstructive and reflux uropathy", "attributes": { "type": "any" } }, { "code": "Kyu1300", "description": "[X]Obstructive and reflux uropathy, unspecified", "attributes": { "type": "any" } }, { "code": "Kyu1F00", "description": "[X]Hydronephrosis with ureteral stricture NEC", "attributes": { "type": "any" } }, { "code": "XaCMe", "description": "Hydronephrosis with ureteropelvic junction obstruction", "attributes": { "type": "any" } }, { "code": "XE0e4", "description": "Urinary obstruction unspecified", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/s19g-6b37", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9471, "version_name": "Obstructive and reflux uropathy", "version_date": "2026-06-08T20:13:51.600235Z", "is_published": true, "is_latest": true } ] } ]