[ { "phenotype_id": "PH4260", "phenotype_version_id": 9478, "name": "Other nervous system infections", "definition": "Other nervous system infections\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:14:12.863212Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:14:12.857223Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": null, "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 10599, "concept_version_id": 18084, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4260", "phenotype_version_id": 9478, "phenotype_name": "Other nervous system infections", "code_attribute_header": [ "type" ], "codes": [ { "code": "1245", "description": "brain abscess/intracranial abscess", "attributes": { "type": "any" } }, { "code": "1248", "description": "spinal abscess", "attributes": { "type": "any" } } ] }, { "concept_id": 10600, "concept_version_id": 18085, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4260", "phenotype_version_id": 9478, "phenotype_name": "Other nervous system infections", "code_attribute_header": [ "type" ], "codes": [ { "code": "A06.6", "description": "Amoebic brain abscess", "attributes": { "type": "any" } }, { "code": "A17.8", "description": "Other tuberculosis of nervous system", "attributes": { "type": "any" } }, { "code": "A17.9", "description": "Tuberculosis of nervous system, unspecified", "attributes": { "type": "any" } }, { "code": "A52.1", "description": "Symptomatic neurosyphilis", "attributes": { "type": "any" } }, { "code": "A52.2", "description": "Asymptomatic neurosyphilis", "attributes": { "type": "any" } }, { "code": "A52.3", "description": "Neurosyphilis, unspecified", "attributes": { "type": "any" } }, { "code": "A80", "description": "Acute poliomyelitis", "attributes": { "type": "any" } }, { "code": "A81", "description": "Atypical virus infections of central nervous system", "attributes": { "type": "any" } }, { "code": "A82", "description": "Rabies", "attributes": { "type": "any" } }, { "code": "A88", "description": "Other viral infections of central nervous system, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "A89", "description": "Unspecified viral infection of central nervous system", "attributes": { "type": "any" } }, { "code": "B02.2", "description": "Zoster with other nervous system involvement", "attributes": { "type": "any" } }, { "code": "B06.0", "description": "Rubella with neurological complications", "attributes": { "type": "any" } }, { "code": "B43.1", "description": "Phaeomycotic brain abscess", "attributes": { "type": "any" } }, { "code": "B45.1", "description": "Cerebral cryptococcosis", "attributes": { "type": "any" } }, { "code": "B50.0", "description": "Plasmodium falciparum malaria with cerebral complications", "attributes": { "type": "any" } }, { "code": "B58.2", "description": "Toxoplasma meningoencephalitis", "attributes": { "type": "any" } }, { "code": "B69.0", "description": "Cysticercosis of central nervous system", "attributes": { "type": "any" } }, { "code": "B90.0", "description": "Sequelae of central nervous system tuberculosis", "attributes": { "type": "any" } }, { "code": "B91", "description": "Sequelae of poliomyelitis", "attributes": { "type": "any" } }, { "code": "G04.2", "description": "Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "G04.8", "description": "Other encephalitis, myelitis and encephalomyelitis", "attributes": { "type": "any" } }, { "code": "G04.9", "description": "Encephalitis, myelitis and encephalomyelitis, unspecified", "attributes": { "type": "any" } }, { "code": "G05.0", "description": "Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G05.1", "description": "Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G05.2", "description": "Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G06", "description": "Intracranial and intraspinal abscess and granuloma", "attributes": { "type": "any" } }, { "code": "G07", "description": "Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G08", "description": "Intracranial and intraspinal phlebitis and thrombophlebitis", "attributes": { "type": "any" } }, { "code": "M89.6", "description": "Osteopathy after poliomyelitis", "attributes": { "type": "any" } } ] }, { "concept_id": 10601, "concept_version_id": 18086, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4260", "phenotype_version_id": 9478, "phenotype_name": "Other nervous system infections", "code_attribute_header": [ "type" ], "codes": [ { "code": "A06.6", "description": "Amoebic brain abscess", "attributes": { "type": "any" } }, { "code": "A17.8", "description": "Other tuberculosis of nervous system", "attributes": { "type": "any" } }, { "code": "A17.9", "description": "Tuberculosis of nervous system, unspecified", "attributes": { "type": "any" } }, { "code": "A52.1", "description": "Symptomatic neurosyphilis", "attributes": { "type": "any" } }, { "code": "A52.2", "description": "Asymptomatic neurosyphilis", "attributes": { "type": "any" } }, { "code": "A52.3", "description": "Neurosyphilis, unspecified", "attributes": { "type": "any" } }, { "code": "A80", "description": "Acute poliomyelitis", "attributes": { "type": "any" } }, { "code": "A81", "description": "Atypical virus infections of central nervous system", "attributes": { "type": "any" } }, { "code": "A82", "description": "Rabies", "attributes": { "type": "any" } }, { "code": "A88", "description": "Other viral infections of central nervous system, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "A89", "description": "Unspecified viral infection of central nervous system", "attributes": { "type": "any" } }, { "code": "B02.2", "description": "Zoster with other nervous system involvement", "attributes": { "type": "any" } }, { "code": "B06.0", "description": "Rubella with neurological complications", "attributes": { "type": "any" } }, { "code": "B43.1", "description": "Phaeomycotic brain abscess", "attributes": { "type": "any" } }, { "code": "B45.1", "description": "Cerebral cryptococcosis", "attributes": { "type": "any" } }, { "code": "B50.0", "description": "Plasmodium falciparum malaria with cerebral complications", "attributes": { "type": "any" } }, { "code": "B58.2", "description": "Toxoplasma meningoencephalitis", "attributes": { "type": "any" } }, { "code": "B69.0", "description": "Cysticercosis of central nervous system", "attributes": { "type": "any" } }, { "code": "B90.0", "description": "Sequelae of central nervous system tuberculosis", "attributes": { "type": "any" } }, { "code": "B91", "description": "Sequelae of poliomyelitis", "attributes": { "type": "any" } }, { "code": "G04.2", "description": "Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "G04.8", "description": "Other encephalitis, myelitis and encephalomyelitis", "attributes": { "type": "any" } }, { "code": "G04.9", "description": "Encephalitis, myelitis and encephalomyelitis, unspecified", "attributes": { "type": "any" } }, { "code": "G05.0", "description": "Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G05.1", "description": "Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G05.2", "description": "Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G06", "description": "Intracranial and intraspinal abscess and granuloma", "attributes": { "type": "any" } }, { "code": "G07", "description": "Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G08", "description": "Intracranial and intraspinal phlebitis and thrombophlebitis", "attributes": { "type": "any" } }, { "code": "M89.6", "description": "Osteopathy after poliomyelitis", "attributes": { "type": "any" } } ] }, { "concept_id": 10602, "concept_version_id": 18087, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4260", "phenotype_version_id": 9478, "phenotype_name": "Other nervous system infections", "code_attribute_header": [ "type" ], "codes": [ { "code": "A06.6", "description": "Amoebic brain abscess", "attributes": { "type": "any" } }, { "code": "A17.8", "description": "Other tuberculosis of nervous system", "attributes": { "type": "any" } }, { "code": "A17.9", "description": "Tuberculosis of nervous system, unspecified", "attributes": { "type": "any" } }, { "code": "A52.1", "description": "Symptomatic neurosyphilis", "attributes": { "type": "any" } }, { "code": "A52.2", "description": "Asymptomatic neurosyphilis", "attributes": { "type": "any" } }, { "code": "A52.3", "description": "Neurosyphilis, unspecified", "attributes": { "type": "any" } }, { "code": "A80", "description": "Acute poliomyelitis", "attributes": { "type": "any" } }, { "code": "A81", "description": "Atypical virus infections of central nervous system", "attributes": { "type": "any" } }, { "code": "A82", "description": "Rabies", "attributes": { "type": "any" } }, { "code": "A88", "description": "Other viral infections of central nervous system, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "A89", "description": "Unspecified viral infection of central nervous system", "attributes": { "type": "any" } }, { "code": "B02.2", "description": "Zoster with other nervous system involvement", "attributes": { "type": "any" } }, { "code": "B06.0", "description": "Rubella with neurological complications", "attributes": { "type": "any" } }, { "code": "B43.1", "description": "Phaeomycotic brain abscess", "attributes": { "type": "any" } }, { "code": "B45.1", "description": "Cerebral cryptococcosis", "attributes": { "type": "any" } }, { "code": "B50.0", "description": "Plasmodium falciparum malaria with cerebral complications", "attributes": { "type": "any" } }, { "code": "B58.2", "description": "Toxoplasma meningoencephalitis", "attributes": { "type": "any" } }, { "code": "B69.0", "description": "Cysticercosis of central nervous system", "attributes": { "type": "any" } }, { "code": "B90.0", "description": "Sequelae of central nervous system tuberculosis", "attributes": { "type": "any" } }, { "code": "B91", "description": "Sequelae of poliomyelitis", "attributes": { "type": "any" } }, { "code": "G04.2", "description": "Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "G04.8", "description": "Other encephalitis, myelitis and encephalomyelitis", "attributes": { "type": "any" } }, { "code": "G04.9", "description": "Encephalitis, myelitis and encephalomyelitis, unspecified", "attributes": { "type": "any" } }, { "code": "G05.0", "description": "Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G05.1", "description": "Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G05.2", "description": "Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G06", "description": "Intracranial and intraspinal abscess and granuloma", "attributes": { "type": "any" } }, { "code": "G07", "description": "Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G08", "description": "Intracranial and intraspinal phlebitis and thrombophlebitis", "attributes": { "type": "any" } }, { "code": "M89.6", "description": "Osteopathy after poliomyelitis", "attributes": { "type": "any" } } ] }, { "concept_id": 10603, "concept_version_id": 18088, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4260", "phenotype_version_id": 9478, "phenotype_name": "Other nervous system infections", "code_attribute_header": [ "type" ], "codes": [ { "code": "A06.6", "description": "Amoebic brain abscess", "attributes": { "type": "any" } }, { "code": "A17.8", "description": "Other tuberculosis of nervous system", "attributes": { "type": "any" } }, { "code": "A17.9", "description": "Tuberculosis of nervous system, unspecified", "attributes": { "type": "any" } }, { "code": "A52.1", "description": "Symptomatic neurosyphilis", "attributes": { "type": "any" } }, { "code": "A52.2", "description": "Asymptomatic neurosyphilis", "attributes": { "type": "any" } }, { "code": "A52.3", "description": "Neurosyphilis, unspecified", "attributes": { "type": "any" } }, { "code": "A80", "description": "Acute poliomyelitis", "attributes": { "type": "any" } }, { "code": "A81", "description": "Atypical virus infections of central nervous system", "attributes": { "type": "any" } }, { "code": "A82", "description": "Rabies", "attributes": { "type": "any" } }, { "code": "A88", "description": "Other viral infections of central nervous system, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "A89", "description": "Unspecified viral infection of central nervous system", "attributes": { "type": "any" } }, { "code": "B02.2", "description": "Zoster with other nervous system involvement", "attributes": { "type": "any" } }, { "code": "B06.0", "description": "Rubella with neurological complications", "attributes": { "type": "any" } }, { "code": "B43.1", "description": "Phaeomycotic brain abscess", "attributes": { "type": "any" } }, { "code": "B45.1", "description": "Cerebral cryptococcosis", "attributes": { "type": "any" } }, { "code": "B50.0", "description": "Plasmodium falciparum malaria with cerebral complications", "attributes": { "type": "any" } }, { "code": "B58.2", "description": "Toxoplasma meningoencephalitis", "attributes": { "type": "any" } }, { "code": "B69.0", "description": "Cysticercosis of central nervous system", "attributes": { "type": "any" } }, { "code": "B90.0", "description": "Sequelae of central nervous system tuberculosis", "attributes": { "type": "any" } }, { "code": "B91", "description": "Sequelae of poliomyelitis", "attributes": { "type": "any" } }, { "code": "G04.2", "description": "Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "G04.8", "description": "Other encephalitis, myelitis and encephalomyelitis", "attributes": { "type": "any" } }, { "code": "G04.9", "description": "Encephalitis, myelitis and encephalomyelitis, unspecified", "attributes": { "type": "any" } }, { "code": "G05.0", "description": "Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G05.1", "description": "Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G05.2", "description": "Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G06", "description": "Intracranial and intraspinal abscess and granuloma", "attributes": { "type": "any" } }, { "code": "G07", "description": "Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere", "attributes": { "type": "any" } }, { "code": "G08", "description": "Intracranial and intraspinal phlebitis and thrombophlebitis", "attributes": { "type": "any" } }, { "code": "M89.6", "description": "Osteopathy after poliomyelitis", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/r9wm-f986", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9478, "version_name": "Other nervous system infections", "version_date": "2026-06-08T20:14:12.873902Z", "is_published": true, "is_latest": true } ] } ]