[ { "phenotype_id": "PH4263", "phenotype_version_id": 9481, "name": "Pancreatitis", "definition": "An acute inflammatory process that leads to necrosis of the pancreatic parenchyma.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:14:31.436989Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:14:31.431599Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Pancreatitis (disorder)", "value": 436857 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 10612, "concept_version_id": 18097, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4263", "phenotype_version_id": 9481, "phenotype_name": "Pancreatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "1165", "description": "pancreatitis", "attributes": { "type": "any" } } ] }, { "concept_id": 10613, "concept_version_id": 18098, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4263", "phenotype_version_id": 9481, "phenotype_name": "Pancreatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "K85", "description": "Acute pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.0", "description": "Alcohol-induced chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.1", "description": "Other chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.3", "description": "Pseudocyst of pancreas", "attributes": { "type": "any" } } ] }, { "concept_id": 10614, "concept_version_id": 18099, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4263", "phenotype_version_id": 9481, "phenotype_name": "Pancreatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "K85", "description": "Acute pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.0", "description": "Alcohol-induced chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.1", "description": "Other chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.3", "description": "Pseudocyst of pancreas", "attributes": { "type": "any" } } ] }, { "concept_id": 10615, "concept_version_id": 18100, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4263", "phenotype_version_id": 9481, "phenotype_name": "Pancreatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "K85", "description": "Acute pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.0", "description": "Alcohol-induced chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.1", "description": "Other chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.3", "description": "Pseudocyst of pancreas", "attributes": { "type": "any" } } ] }, { "concept_id": 10616, "concept_version_id": 18101, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4263", "phenotype_version_id": 9481, "phenotype_name": "Pancreatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "K85", "description": "Acute pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.0", "description": "Alcohol-induced chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.1", "description": "Other chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "K86.3", "description": "Pseudocyst of pancreas", "attributes": { "type": "any" } } ] }, { "concept_id": 10617, "concept_version_id": 18102, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4263", "phenotype_version_id": 9481, "phenotype_name": "Pancreatitis", "code_attribute_header": [ "type" ], "codes": [ { "code": "14CG.00", "description": "History of acute pancreatitis", "attributes": { "type": "prevalent" } }, { "code": "14CH.00", "description": "History of chronic pancreatitis", "attributes": { "type": "prevalent" } }, { "code": "A723.00", "description": "Mumps pancreatitis", "attributes": { "type": "any" } }, { "code": "A785100", "description": "Cytomegaloviral pancreatitis", "attributes": { "type": "any" } }, { "code": "D201612", "description": "Pancytopenia with pancreatitis", "attributes": { "type": "any" } }, { "code": "J670.00", "description": "Acute pancreatitis", "attributes": { "type": "any" } }, { "code": "J670000", "description": "Acute pancreatitis unspecified", "attributes": { "type": "any" } }, { "code": "J670100", "description": "Acute recurrent pancreatitis", "attributes": { "type": "any" } }, { "code": "J670200", "description": "Acute haemorrhagic pancreatitis", "attributes": { "type": "any" } }, { "code": "J670300", "description": "Acute suppurative pancreatitis", "attributes": { "type": "any" } }, { "code": "J670400", "description": "Subacute pancreatitis", "attributes": { "type": "any" } }, { "code": "J670500", "description": "Gallstone acute pancreatitis", "attributes": { "type": "any" } }, { "code": "J670600", "description": "Idiopathic acute pancreatitis", "attributes": { "type": "any" } }, { "code": "J670700", "description": "Biliary acute pancreatitis", "attributes": { "type": "any" } }, { "code": "J670800", "description": "Alcohol-induced acute pancreatitis", "attributes": { "type": "any" } }, { "code": "J670900", "description": "Drug-induced acute pancreatitis", "attributes": { "type": "any" } }, { "code": "J670y00", "description": "Other acute pancreatitis", "attributes": { "type": "any" } }, { "code": "J670z00", "description": "Acute pancreatitis NOS", "attributes": { "type": "any" } }, { "code": "J670z11", "description": "Pancreatitis", "attributes": { "type": "any" } }, { "code": "J671.00", "description": "Chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "J671000", "description": "Alcohol-induced chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "J671100", "description": "Gallstone chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "J672100", "description": "Pseudocyst of pancreas", "attributes": { "type": "any" } }, { "code": "Jyu8400", "description": "[X]Other chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "X308i", "description": "Gallstone acute pancreatitis", "attributes": { "type": "any" } }, { "code": "X308j", "description": "Alcohol-induced acute pancreatitis", "attributes": { "type": "any" } }, { "code": "X308k", "description": "Idiopathic acute pancreatitis", "attributes": { "type": "any" } }, { "code": "X308l", "description": "Drug-induced acute pancreatitis", "attributes": { "type": "any" } }, { "code": "X308p", "description": "Cytomegaloviral pancreatitis", "attributes": { "type": "any" } }, { "code": "X308u", "description": "Gallstone chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "X308v", "description": "Alcohol-induced chronic pancreatitis", "attributes": { "type": "any" } }, { "code": "XaLou", "description": "History of acute pancreatitis", "attributes": { "type": "prevalent" } }, { "code": "XaLov", "description": "History of chronic pancreatitis", "attributes": { "type": "prevalent" } }, { "code": "XaYaK", "description": "Biliary acute pancreatitis", "attributes": { "type": "any" } }, { "code": "XE0bH", "description": "Acute pancreatitis NOS", "attributes": { "type": "any" } }, { "code": "XE13v", "description": "Pancytopenia NOS", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/6tj1-tp48", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9481, "version_name": "Pancreatitis", "version_date": "2026-06-08T20:14:31.448135Z", "is_published": true, "is_latest": true } ] } ]