[
  {
    "phenotype_id": "PH4269",
    "phenotype_version_id": 9487,
    "name": "Personality disorders",
    "definition": "A major deviation from normal patterns of behavior.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:14:48.877639Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:14:48.871750Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Personality disorder (disorder)",
        "value": 635732
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10646,
        "concept_version_id": 18131,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4269",
        "phenotype_version_id": 9487,
        "phenotype_name": "Personality disorders",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "F60",
            "description": "Specific personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F61",
            "description": "Mixed and other personality disorders",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10647,
        "concept_version_id": 18132,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4269",
        "phenotype_version_id": 9487,
        "phenotype_name": "Personality disorders",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "F60",
            "description": "Specific personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F61",
            "description": "Mixed and other personality disorders",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10648,
        "concept_version_id": 18133,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4269",
        "phenotype_version_id": 9487,
        "phenotype_name": "Personality disorders",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "F60",
            "description": "Specific personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F61",
            "description": "Mixed and other personality disorders",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10649,
        "concept_version_id": 18134,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4269",
        "phenotype_version_id": 9487,
        "phenotype_name": "Personality disorders",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "F60",
            "description": "Specific personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "F61",
            "description": "Mixed and other personality disorders",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10650,
        "concept_version_id": 18135,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4269",
        "phenotype_version_id": 9487,
        "phenotype_name": "Personality disorders",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "E21..00",
            "description": "Personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E210.00",
            "description": "Paranoid personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21..11",
            "description": "Neurotic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E212.00",
            "description": "Schizoid personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E212000",
            "description": "Unspecified schizoid personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E212100",
            "description": "Introverted personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E212200",
            "description": "Schizotypal personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E212z00",
            "description": "Schizoid personality disorder NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E213.00",
            "description": "Explosive personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E213.11",
            "description": "Aggressive personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E213.12",
            "description": "Quarrelsome personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E214.00",
            "description": "Compulsive personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E214000",
            "description": "Anankastic personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E214100",
            "description": "Obsessional personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E214.11",
            "description": "Anancastic personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E214z00",
            "description": "Compulsive personality disorder NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E215.00",
            "description": "Histrionic personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E215000",
            "description": "Unspecified histrionic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E215.11",
            "description": "Hysterical personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E215200",
            "description": "Emotionally unstable personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E215300",
            "description": "Psychoinfantile personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E215z00",
            "description": "Histrionic personality disorder NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E216.00",
            "description": "Inadequate personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E216.11",
            "description": "Asthenic personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E216.12",
            "description": "Dependent personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E216.13",
            "description": "Labile personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E217.00",
            "description": "Antisocial or sociopathic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E217.11",
            "description": "Amoral personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21y.00",
            "description": "Other personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21y000",
            "description": "Narcissistic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21y100",
            "description": "Avoidant personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21y200",
            "description": "Borderline personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21y300",
            "description": "Passive-aggressive personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21y400",
            "description": "Eccentric personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21y500",
            "description": "Immature personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21y600",
            "description": "Masochistic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21y700",
            "description": "Psychoneurotic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21y711",
            "description": "Neurotic personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21yz00",
            "description": "Other personality disorder NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21yz11",
            "description": "Manipulative personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21z.00",
            "description": "Personality disorder NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E21z.11",
            "description": "Psychopathic personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "E2C3500",
            "description": "Isolated explosive disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60.00",
            "description": "[X]Specific personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60000",
            "description": "[X]Paranoid personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60013",
            "description": "[X]Querulant personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60014",
            "description": "[X]Sensitive paranoid personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60100",
            "description": "[X]Schizoid personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60200",
            "description": "[X]Dissocial personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60211",
            "description": "[X]Amoral personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60212",
            "description": "[X]Antisocial personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60213",
            "description": "[X]Asocial personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60214",
            "description": "[X]Psychopathic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60215",
            "description": "[X]Sociopathic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60300",
            "description": "[X]Emotionally unstable personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60311",
            "description": "[X]Aggressive personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60312",
            "description": "[X]Borderline personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60313",
            "description": "[X]Explosive personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60400",
            "description": "[X]Histrionic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60411",
            "description": "[X]Hysterical personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60412",
            "description": "[X]Psychoinfantile personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60500",
            "description": "[X]Anankastic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60511",
            "description": "[X]Compulsive personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60512",
            "description": "[X]Obsessional personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60513",
            "description": "[X]Obsessive-compulsive personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60600",
            "description": "[X]Anxious [avoidant] personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60700",
            "description": "[X]Dependent personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60711",
            "description": "[X]Asthenic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60712",
            "description": "[X]Inadequate personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60713",
            "description": "[X]Passive personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60714",
            "description": "[X]Self defeating personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60800",
            "description": "[X]Addictive personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60y00",
            "description": "[X]Other specific personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60y11",
            "description": "[X]Eccentric personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60y12",
            "description": "[X]Haltlose type personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60y13",
            "description": "[X]Immature personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60y14",
            "description": "[X]Narcissistic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60y16",
            "description": "[X]Psychoneurotic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60z00",
            "description": "[X]Personality disorder, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60z11",
            "description": "[X]Character neurosis NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu60z12",
            "description": "[X]Pathological personality NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Eu61.00",
            "description": "[X]Mixed and other personality disorders",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "X00T6",
            "description": "Explosive personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaJSA",
            "description": "[X]Addictive personality",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1YF",
            "description": "Paranoid personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1YK",
            "description": "Psychoneurotic personality disorder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1YL",
            "description": "Other personality disorder NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1YM",
            "description": "Personality disorder NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1Zy",
            "description": "[X]Other specific personality disorders",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/wvc5-gn56",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9487,
        "version_name": "Personality disorders",
        "version_date": "2026-06-08T20:14:48.887881Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]