[ { "phenotype_id": "PH427", "phenotype_version_id": 854, "name": "Lithium Levels", "definition": "Patient level data were extracted from the General Practice Research Database (GPRD), which contains anonymised, patient based data on morbidity, prescribing, treatment, and referral collected from over 500 general practices, covering about 7% of the UK population (4.4 million patients).14 Data are in Read code format—a hierarchical system used to code clinical data. Additional data on prescriptions and test results are available as free-text entries. We selected a sample of 148 practices that provided data to the GPRD continuously between January 2000 and December 2007, structured to include a range of list (patient panel) sizes. Selected practices were nationally representative in terms of patient sex and age distribution and area socioeconomic deprivation but had a relatively large average list size, reflecting a bias towards larger practices in the GPRD. Overall, the selected practices performed marginally better than national practices on the clinical indicators in the Quality and Outcomes Framework. A random selection of 4500 patients registered for at least one day between 1 January 2000 and 31 December 2007 was drawn from each practice. For practices with fewer than 4501 patients, all patients were selected. The final sample consisted of 653 500 patients. Patients with relevant conditions were identified from their diagnostic Read codes. Patients for whom targets were met were identified from the relevant Read codes and free-text terms.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves, Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework. BMJ, 342:d3590, 2011." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:18:58.988563Z", "author": "Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:18:58.988591Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Biomarker", "value": "1" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 }, { "name": "OXMIS codes", "value": 15 } ], "event_date_range": "01/01/2000 - 31/12/2007", "concept_information": [ { "concept_id": 1779, "concept_version_id": 4696, "concept_name": "Lithium Levels - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH427", "phenotype_version_id": 854, "phenotype_name": "Lithium Levels", "code_attribute_header": [ "Entity type", "Coding System (OXMIS Read)", "Category" ], "codes": [ { "code": "44vE.00", "description": "Lithium level therapeutic", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "44W8.00", "description": "Serum lithium level", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "44W8000", "description": "Lithium level therapeutic", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "44W8100", "description": "Lithium level high - toxic", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "44W8.11", "description": "Lithium: blood level", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "44W8200", "description": "Lithium level low", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "46P3.00", "description": "Urine lithium", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "6657.00", "description": "On lithium", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "6657.11", "description": "Lithium monitoring", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "6657.12", "description": "Started lithium", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "665B.00", "description": "Lithium stopped", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "d615.00", "description": "", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "d616.00", "description": "", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "d61z.00", "description": "", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } }, { "code": "R105300", "description": "[D]Lithium; blood level abnormal", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "Read", "Category": "diagnostic" } } ] }, { "concept_id": 1780, "concept_version_id": 4698, "concept_name": "Lithium Levels - Primary Care", "coding_system": { "id": 15, "name": "OXMIS codes", "description": "OXMIS codes" }, "phenotype_id": "PH427", "phenotype_version_id": 854, "phenotype_name": "Lithium Levels", "code_attribute_header": [ "Entity type", "Coding System (OXMIS Read)", "Category" ], "codes": [ { "code": "9859", "description": "TOXICITY LITHIUM", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } }, { "code": "L 130L", "description": "SERUM LITHIUM LEVEL", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } }, { "code": "L 130L9", "description": "LITHIUM LEVEL (mmol/l)", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } }, { "code": "L 130LA", "description": "LITHIUM LEVEL", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } }, { "code": "L 130LB", "description": "LITHIUM LEVEL LOW", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } }, { "code": "L 130LC", "description": "LITHIUM LEVEL THERAPEUTIC", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } }, { "code": "L 130LD", "description": "LITHIUM LEVEL HIGH", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } }, { "code": "T3551CA", "description": "LITHIUM THERAPY", "attributes": { "Entity type": "Lithium levels", "Coding System (OXMIS Read)": "OXMIS", "Category": "diagnostic" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/kqrq-5f44", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 854, "version_name": "Lithium Levels", "version_date": "2021-10-06T16:18:59.017340Z", "is_published": true, "is_latest": true } ] } ]