[
  {
    "phenotype_id": "PH4287",
    "phenotype_version_id": 9505,
    "name": "Prematurity",
    "definition": "An infant born before 37 weeks of gestation.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:15:44.523279Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:15:44.517687Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Prematurity of infant (disorder)",
        "value": 751885
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10755,
        "concept_version_id": 18240,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4287",
        "phenotype_version_id": 9505,
        "phenotype_name": "Prematurity",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "P07.2",
            "description": "Extreme immaturity",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "P07.3",
            "description": "Other preterm infants",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10756,
        "concept_version_id": 18241,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4287",
        "phenotype_version_id": 9505,
        "phenotype_name": "Prematurity",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "P07.2",
            "description": "Extreme immaturity",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "P07.3",
            "description": "Other preterm infants",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10757,
        "concept_version_id": 18242,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4287",
        "phenotype_version_id": 9505,
        "phenotype_name": "Prematurity",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "P07.2",
            "description": "Extreme immaturity",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "P07.3",
            "description": "Other preterm infants",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10758,
        "concept_version_id": 18243,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4287",
        "phenotype_version_id": 9505,
        "phenotype_name": "Prematurity",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "P07.2",
            "description": "Extreme immaturity",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "P07.3",
            "description": "Other preterm infants",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10759,
        "concept_version_id": 18244,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4287",
        "phenotype_version_id": 9505,
        "phenotype_name": "Prematurity",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1546.00",
            "description": "H/O: premature delivery",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "6351.00",
            "description": "Baby premature 36-38 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "635..13",
            "description": "Premature baby",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "6352.00",
            "description": "Baby v. premature 32-36 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "6353.00",
            "description": "Baby extremely prem.28-32 week",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "6356.00",
            "description": "Baby premature 26-28 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "6357.00",
            "description": "Baby premature 24-26 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "635A.00",
            "description": "Baby premature 37 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "635B.00",
            "description": "Baby premature 36 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "635C.00",
            "description": "Preterm infant status",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "635C.11",
            "description": "Preterm",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q110.00",
            "description": "Very premature - less than 1000g or less than 28 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q110.11",
            "description": "Immature baby",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q111.00",
            "description": "Premature - weight 1000g-2499g or gestation of 28-37weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q11..11",
            "description": "Baby born premature",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q112.00",
            "description": "Extreme immaturity",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q112.11",
            "description": "Extreme prematurity - less than 28 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q116.00",
            "description": "Premature infant 28-37 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q11z.00",
            "description": "Born premature NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q317100",
            "description": "Prematurity with interstitial pulmonary fibrosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q432.00",
            "description": "Preterm delivery associated jaundice",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Q456.00",
            "description": "Anaemia of prematurity",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Qyu1100",
            "description": "[X]Other preterm infants",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Xa0AU",
            "description": "Extreme immaturity",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaCJX",
            "description": "Baby premature 37 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaCJY",
            "description": "Baby premature 36 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaCMV",
            "description": "Premature infant 28-37 weeks",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaQ25",
            "description": "Preterm infant status",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1eX",
            "description": "Very premature - less than 1000g or less than 28 weeks",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/prnx-sg91",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9505,
        "version_name": "Prematurity",
        "version_date": "2026-06-08T20:15:44.534270Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]