[
  {
    "phenotype_id": "PH4291",
    "phenotype_version_id": 9509,
    "name": "Primary Malignancy_Bladder",
    "definition": "Malignant neoplasm of bladder.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:15:55.276679Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:15:55.269833Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Malignant neoplasm of urinary bladder (disorder)",
        "value": 452061
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10779,
        "concept_version_id": 18264,
        "concept_name": "Cancer code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4291",
        "phenotype_version_id": 9509,
        "phenotype_name": "Primary Malignancy_Bladder",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1035",
            "description": "bladder cancer",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10780,
        "concept_version_id": 18265,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4291",
        "phenotype_version_id": 9509,
        "phenotype_name": "Primary Malignancy_Bladder",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C67",
            "description": "Malignant neoplasm of bladder",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10781,
        "concept_version_id": 18266,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4291",
        "phenotype_version_id": 9509,
        "phenotype_name": "Primary Malignancy_Bladder",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C67",
            "description": "Malignant neoplasm of bladder",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10782,
        "concept_version_id": 18267,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4291",
        "phenotype_version_id": 9509,
        "phenotype_name": "Primary Malignancy_Bladder",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C67",
            "description": "Malignant neoplasm of bladder",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10783,
        "concept_version_id": 18268,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4291",
        "phenotype_version_id": 9509,
        "phenotype_name": "Primary Malignancy_Bladder",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C67",
            "description": "Malignant neoplasm of bladder",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10784,
        "concept_version_id": 18269,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4291",
        "phenotype_version_id": 9509,
        "phenotype_name": "Primary Malignancy_Bladder",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "B49..00",
            "description": "Malignant neoplasm of urinary bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B490.00",
            "description": "Malignant neoplasm of trigone of urinary bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B491.00",
            "description": "Malignant neoplasm of dome of urinary bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B492.00",
            "description": "Malignant neoplasm of lateral wall of urinary bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B493.00",
            "description": "Malignant neoplasm of anterior wall of urinary bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B494.00",
            "description": "Malignant neoplasm of posterior wall of urinary bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B495.00",
            "description": "Malignant neoplasm of bladder neck",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B496.00",
            "description": "Malignant neoplasm of ureteric orifice",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B497.00",
            "description": "Malignant neoplasm of urachus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B498.00",
            "description": "Local recurrence of malignant tumour of urinary bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B49y.00",
            "description": "Malignant neoplasm of other site of urinary bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B49y000",
            "description": "Malignant neoplasm, overlapping lesion of bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B49z.00",
            "description": "Malignant neoplasm of urinary bladder NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaFrL",
            "description": "Local recurrence of malignant tumour of urinary bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "ZV10511",
            "description": "[V]Personal history of malignant neoplasm of bladder",
            "attributes": {
              "type": "prevalent"
            }
          }
        ]
      },
      {
        "concept_id": 10785,
        "concept_version_id": 18270,
        "concept_name": "Type of cancer: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4291",
        "phenotype_version_id": 9509,
        "phenotype_name": "Primary Malignancy_Bladder",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C67",
            "description": "Malignant neoplasm of bladder",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/7366-q334",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9509,
        "version_name": "Primary Malignancy_Bladder",
        "version_date": "2026-06-08T20:15:55.286833Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]