[
  {
    "phenotype_id": "PH4299",
    "phenotype_version_id": 9517,
    "name": "Primary Malignancy_Lymph Nodes",
    "definition": "A primary or metastatic malignant neoplasm that affects the lymph nodes.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:16:22.429146Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:16:22.421654Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Neoplasm of lymph node (disorder)",
        "value": 337291
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 10835,
        "concept_version_id": 18320,
        "concept_name": "Cancer code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4299",
        "phenotype_version_id": 9517,
        "phenotype_name": "Primary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1070",
            "description": "malignant lymph node, unspecified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10836,
        "concept_version_id": 18321,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4299",
        "phenotype_version_id": 9517,
        "phenotype_name": "Primary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C96.9",
            "description": "Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10837,
        "concept_version_id": 18322,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4299",
        "phenotype_version_id": 9517,
        "phenotype_name": "Primary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C96.9",
            "description": "Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10838,
        "concept_version_id": 18323,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4299",
        "phenotype_version_id": 9517,
        "phenotype_name": "Primary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C96.9",
            "description": "Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10839,
        "concept_version_id": 18324,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4299",
        "phenotype_version_id": 9517,
        "phenotype_name": "Primary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C96.9",
            "description": "Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10840,
        "concept_version_id": 18325,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4299",
        "phenotype_version_id": 9517,
        "phenotype_name": "Primary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "B62x3",
            "description": "Malignant reticuloendotheliosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62y8",
            "description": "Malignant lymphoma NOS of lymph nodes of multiple sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62z.",
            "description": "Malignant neoplasms of lymphoid and histiocytic tissue NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62z0",
            "description": "Unspecified malignant neoplasm of lymphoid and histiocytic tissue of unspecified site",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62z1",
            "description": "Unspecified malignant neoplasm of lymphoid and histiocytic tissue of lymph nodes of head, face and neck",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62z2",
            "description": "Unspecified malignant neoplasm of lymphoid and histiocytic tissue of intrathoracic lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62z3",
            "description": "Unspecified malignant neoplasm of lymphoid and histiocytic tissue of intra-abdominal lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62z4",
            "description": "Unspecified malignant neoplasm of lymphoid and histiocytic tissue of lymph nodes of axilla and upper limb",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62z5",
            "description": "Unspecified malignant neoplasm of lymphoid and histiocytic tissue of lymph nodes of inguinal region and lower limb",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62z6",
            "description": "Unspecified malignant neoplasm of lymphoid and histiocytic tissue of intrapelvic lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62z7",
            "description": "Unspecified malignant neoplasm of lymphoid and histiocytic tissue of spleen",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62z8",
            "description": "Unspecified malignant neoplasm of lymphoid and histiocytic tissue of lymph nodes of multiple sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B62zz",
            "description": "Immunoproliferative neoplasm",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B6z..",
            "description": "Malignant neoplasm lymphatic or haematopoietic tissue NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "ByuDB",
            "description": "[X]Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 10841,
        "concept_version_id": 18326,
        "concept_name": "Type of cancer: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4299",
        "phenotype_version_id": 9517,
        "phenotype_name": "Primary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C96.9",
            "description": "Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/8e1v-ay53",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9517,
        "version_name": "Primary Malignancy_Lymph Nodes",
        "version_date": "2026-06-08T20:16:22.437542Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]