[
  {
    "phenotype_id": "PH4325",
    "phenotype_version_id": 9543,
    "name": "Postinfective and reactive arthropathies",
    "definition": "An aseptic, inflammatory arthritis developing secondary to a primary extra\\-articular infection, most typically of the gastrointestinal tract or urogenital system..\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:17:40.598119Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:17:40.591291Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Reactive arthritis (disorder)",
        "value": 325110
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 11008,
        "concept_version_id": 18493,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4325",
        "phenotype_version_id": 9543,
        "phenotype_name": "Postinfective and reactive arthropathies",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "M02",
            "description": "Reactive arthropathies",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "M03",
            "description": "Postinfective and reactive arthropathies in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11009,
        "concept_version_id": 18494,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4325",
        "phenotype_version_id": 9543,
        "phenotype_name": "Postinfective and reactive arthropathies",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "M02",
            "description": "Reactive arthropathies",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "M03",
            "description": "Postinfective and reactive arthropathies in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11010,
        "concept_version_id": 18495,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4325",
        "phenotype_version_id": 9543,
        "phenotype_name": "Postinfective and reactive arthropathies",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "M02",
            "description": "Reactive arthropathies",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "M03",
            "description": "Postinfective and reactive arthropathies in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11011,
        "concept_version_id": 18496,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4325",
        "phenotype_version_id": 9543,
        "phenotype_name": "Postinfective and reactive arthropathies",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "M02",
            "description": "Reactive arthropathies",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "M03",
            "description": "Postinfective and reactive arthropathies in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11012,
        "concept_version_id": 18497,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4325",
        "phenotype_version_id": 9543,
        "phenotype_name": "Postinfective and reactive arthropathies",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "A993.00",
            "description": "Reiter's disease / syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "A993.11",
            "description": "Reiter's syndrome",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "M211400",
            "description": "Keratoderma blennorrhagica",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N011.00",
            "description": "Sexually acquired reactive arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N011.12",
            "description": "Arthropathy in Reiter's disease",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N011400",
            "description": "Sexually acquired reactive arthropathy of the hand",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N011600",
            "description": "Sexually acquired reactive arthropathy of the lower leg",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N011x00",
            "description": "Sexually acquired reactive arthropathy of multiple sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N011z00",
            "description": "Sexually acquired reactive arthropathy NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N013.00",
            "description": "Postdysenteric reactive arthropathy",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N013400",
            "description": "Postdysenteric reactive arthropathy of the hand",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N013700",
            "description": "Postdysenteric reactive arthropathy of the ankle and foot",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N013x00",
            "description": "Postdysenteric reactive arthropathy of multiple sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01w.00",
            "description": "Reactive arthropathy, unspecified",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01w000",
            "description": "Reactive arthropathy of shoulder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01w100",
            "description": "Reactive arthropathy of sternoclavicular joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01w300",
            "description": "Reactive arthropathy of elbow",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01w500",
            "description": "Reactive arthropathy of wrist",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01w600",
            "description": "Reactive arthropathy of MCP joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01w700",
            "description": "Reactive arthropathy of PIP joint of finger",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01w800",
            "description": "Reactive arthropathy of DIP joint of finger",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01w900",
            "description": "Reactive arthropathy of hip",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01wA00",
            "description": "Reactive arthropathy of sacro-iliac joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01wB00",
            "description": "Reactive arthropathy of knee",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01wD00",
            "description": "Reactive arthropathy of ankle",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01wH00",
            "description": "Reactive arthropathy of 1st MTP joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01wJ00",
            "description": "Reactive arthropathy of lesser MTP joint",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N01wK00",
            "description": "Reactive arthropathy of IP joint of toe",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "N038.00",
            "description": "Reactive arthropathies",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Nyu0300",
            "description": "[X]Other reactive arthropathies",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Nyu0400",
            "description": "[X]Other postinfectious arthropathies in diseases CE",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Nyu0500",
            "description": "[X]Reactive arthropathy in other diseases CE",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/0y9t-qq54",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9543,
        "version_name": "Postinfective and reactive arthropathies",
        "version_date": "2026-06-08T20:17:40.609651Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]