[
  {
    "phenotype_id": "PH4326",
    "phenotype_version_id": 9544,
    "name": "Respiratory failure",
    "definition": "The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:17:43.276634Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:17:43.269231Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Respiratory failure (disorder)",
        "value": 28452
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 11013,
        "concept_version_id": 18498,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4326",
        "phenotype_version_id": 9544,
        "phenotype_name": "Respiratory failure",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1124",
            "description": "respiratory failure",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11014,
        "concept_version_id": 18499,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4326",
        "phenotype_version_id": 9544,
        "phenotype_name": "Respiratory failure",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "J96",
            "description": "Respiratory failure, not elsewhere classified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11015,
        "concept_version_id": 18500,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4326",
        "phenotype_version_id": 9544,
        "phenotype_name": "Respiratory failure",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "J96",
            "description": "Respiratory failure, not elsewhere classified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11016,
        "concept_version_id": 18501,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4326",
        "phenotype_version_id": 9544,
        "phenotype_name": "Respiratory failure",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "J96",
            "description": "Respiratory failure, not elsewhere classified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11017,
        "concept_version_id": 18502,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4326",
        "phenotype_version_id": 9544,
        "phenotype_name": "Respiratory failure",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "J96",
            "description": "Respiratory failure, not elsewhere classified",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11018,
        "concept_version_id": 18503,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4326",
        "phenotype_version_id": 9544,
        "phenotype_name": "Respiratory failure",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "Fy04.00",
            "description": "Sleep-related respiratory failure",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H59..00",
            "description": "Respiratory failure",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H590.00",
            "description": "Acute respiratory failure",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H591.00",
            "description": "Chronic respiratory failure",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H592.00",
            "description": "Chronic type 1 respiratory failure",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "H593.00",
            "description": "Chronic type 2 respiratory failure",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "R2y1.00",
            "description": "[D]Respiratory failure",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "R2y1z00",
            "description": "[D]Respiratory failure NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "X008F",
            "description": "Sleep-related respiratory failure",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaO5l",
            "description": "Chronic type 1 respiratory failure",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaO5m",
            "description": "Chronic type 2 respiratory failure",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XM09V",
            "description": "Respiratory failure",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/vxen-rh72",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9544,
        "version_name": "Respiratory failure",
        "version_date": "2026-06-08T20:17:43.289664Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]