[
  {
    "phenotype_id": "PH4343",
    "phenotype_version_id": 9561,
    "name": "Secondary Malignancy_Lymph Nodes",
    "definition": "Cancer which has spread from a primary site of origin to the lymph nodes.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:18:41.320365Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:18:41.314362Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Metastatic malignant neoplasm to lymph node (disorder)",
        "value": 624138
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 11120,
        "concept_version_id": 18605,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4343",
        "phenotype_version_id": 9561,
        "phenotype_name": "Secondary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C77",
            "description": "Secondary and unspecified malignant neoplasm of lymph nodes",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11121,
        "concept_version_id": 18606,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4343",
        "phenotype_version_id": 9561,
        "phenotype_name": "Secondary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C77",
            "description": "Secondary and unspecified malignant neoplasm of lymph nodes",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11122,
        "concept_version_id": 18607,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4343",
        "phenotype_version_id": 9561,
        "phenotype_name": "Secondary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C77",
            "description": "Secondary and unspecified malignant neoplasm of lymph nodes",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11123,
        "concept_version_id": 18608,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4343",
        "phenotype_version_id": 9561,
        "phenotype_name": "Secondary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C77",
            "description": "Secondary and unspecified malignant neoplasm of lymph nodes",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11124,
        "concept_version_id": 18609,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4343",
        "phenotype_version_id": 9561,
        "phenotype_name": "Secondary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "B56..00",
            "description": "Secondary and unspecified malignant neoplasm of lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560.00",
            "description": "Secondary and unspec malig neop lymph nodes head/face/neck",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560000",
            "description": "Secondary and unspec malig neop of superficial parotid LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560100",
            "description": "Secondary and unspec malignant neoplasm mastoid lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560200",
            "description": "Secondary and unspec malig neop superficial cervical LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560300",
            "description": "Secondary and unspec malignant neoplasm occipital lymph node",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560400",
            "description": "Secondary and unspec malig neop deep parotid lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560500",
            "description": "Secondary and unspec malig neop submandibular lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560600",
            "description": "Secondary and unspec malig neop of facial lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560700",
            "description": "Secondary and unspec malig neop submental lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560800",
            "description": "Secondary and unspec malig neop anterior cervical LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560900",
            "description": "Secondary and unspec malig neop deep cervical LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B560z00",
            "description": "Secondary unspec malig neop lymph nodes head/face/neck NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561.00",
            "description": "Secondary and unspec malig neop intrathoracic lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561000",
            "description": "Secondary and unspec malig neop internal mammary lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B56..11",
            "description": "Lymph node metastases",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561100",
            "description": "Secondary and unspec malig neop intercostal lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561200",
            "description": "Secondary and unspec malig neop diaphragmatic lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561300",
            "description": "Secondary and unspec malig neop ant mediastinal lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561400",
            "description": "Secondary and unspec malig neop post mediastinal lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561500",
            "description": "Secondary and unspec malig neop paratracheal lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561600",
            "description": "Secondary and unspec malig neop superfic tracheobronchial LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561700",
            "description": "Secondary and unspec malig neop inferior tracheobronchial LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561800",
            "description": "Secondary and unspec malig neop bronchopulmonary lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561900",
            "description": "Secondary and unspec malig neop pulmonary lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B561z00",
            "description": "Secondary and unspec malig neop intrathoracic LN NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B562.00",
            "description": "Secondary and unspec malig neop intra-abdominal lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B562000",
            "description": "Secondary and unspec malig neop coeliac lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B562100",
            "description": "Secondary and unspec malig neop superficial mesenteric LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B562200",
            "description": "Secondary and unspec malig neop inferior mesenteric LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B562300",
            "description": "Secondary and unspec malig neop common iliac lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B562400",
            "description": "Secondary and unspec malig neop external iliac lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B562z00",
            "description": "Secondary and unspec malig neop intra-abdominal LN NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B563.00",
            "description": "Secondary and unspec malig neop axilla and upper limb LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B563000",
            "description": "Secondary and unspec malig neop axillary lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B563100",
            "description": "Secondary and unspec malig neop supratrochlear lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B563200",
            "description": "Secondary and unspec malig neop infraclavicular lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B563300",
            "description": "Secondary and unspec malig neop pectoral lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B563z00",
            "description": "Secondary and unspec malig neop axilla and upper limb LN NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B564.00",
            "description": "Secondary and unspec malig neop inguinal and lower limb LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B564000",
            "description": "Secondary and unspec malig neop superficial inguinal LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B564100",
            "description": "Secondary and unspec malig neop deep inguinal lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B564z00",
            "description": "Secondary and unspec malig neop of inguinal and leg LN NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B565.00",
            "description": "Secondary and unspec malig neop intrapelvic lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B565000",
            "description": "Secondary and unspec malig neop internal iliac lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B565200",
            "description": "Secondary and unspec malig neop circumflex iliac LN",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B565300",
            "description": "Secondary and unspec malig neop sacral lymph nodes",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B565z00",
            "description": "Secondary and unspec malig neop intrapelvic LN NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B56y.00",
            "description": "Secondary and unspec malig neop lymph nodes multiple sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B56z.00",
            "description": "Secondary and unspec malig neop lymph nodes NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "ByuC200",
            "description": "[X]2ndry+unspcf malignant neoplasm lymph nodes/multi regions",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE2xB",
            "description": "Secondary and unspecified malignant neoplasm of lymph nodes",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11125,
        "concept_version_id": 18610,
        "concept_name": "Type of cancer: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4343",
        "phenotype_version_id": 9561,
        "phenotype_name": "Secondary Malignancy_Lymph Nodes",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C77",
            "description": "Secondary and unspecified malignant neoplasm of lymph nodes",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/xf7x-6j96",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9561,
        "version_name": "Secondary Malignancy_Lymph Nodes",
        "version_date": "2026-06-08T20:18:41.331563Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]