[
  {
    "phenotype_id": "PH4345",
    "phenotype_version_id": 9563,
    "name": "Secondary Malignancy_Other organs",
    "definition": "Secondary malignancy of other specified and nonspecified organs and sites\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:18:50.942896Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:18:50.937729Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": null,
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 11132,
        "concept_version_id": 18617,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4345",
        "phenotype_version_id": 9563,
        "phenotype_name": "Secondary Malignancy_Other organs",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C78.1",
            "description": "Secondary malignant neoplasm of mediastinum",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C78.3",
            "description": "Secondary malignant neoplasm of other and unspecified respiratory organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C78.8",
            "description": "Secondary malignant neoplasm of other and unspecified digestive organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.0",
            "description": "Secondary malignant neoplasm of kidney and renal pelvis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.1",
            "description": "Secondary malignant neoplasm of bladder and other and unspecified urinary organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.2",
            "description": "Secondary malignant neoplasm of skin",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.6",
            "description": "Secondary malignant neoplasm of ovary",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.8",
            "description": "Secondary malignant neoplasm of other specified sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.9",
            "description": "Secondary malignant neoplasm, unspecified site",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11133,
        "concept_version_id": 18618,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4345",
        "phenotype_version_id": 9563,
        "phenotype_name": "Secondary Malignancy_Other organs",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C78.1",
            "description": "Secondary malignant neoplasm of mediastinum",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C78.3",
            "description": "Secondary malignant neoplasm of other and unspecified respiratory organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C78.8",
            "description": "Secondary malignant neoplasm of other and unspecified digestive organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.0",
            "description": "Secondary malignant neoplasm of kidney and renal pelvis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.1",
            "description": "Secondary malignant neoplasm of bladder and other and unspecified urinary organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.2",
            "description": "Secondary malignant neoplasm of skin",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.6",
            "description": "Secondary malignant neoplasm of ovary",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.8",
            "description": "Secondary malignant neoplasm of other specified sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.9",
            "description": "Secondary malignant neoplasm, unspecified site",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11134,
        "concept_version_id": 18619,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4345",
        "phenotype_version_id": 9563,
        "phenotype_name": "Secondary Malignancy_Other organs",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C78.1",
            "description": "Secondary malignant neoplasm of mediastinum",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C78.3",
            "description": "Secondary malignant neoplasm of other and unspecified respiratory organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C78.8",
            "description": "Secondary malignant neoplasm of other and unspecified digestive organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.0",
            "description": "Secondary malignant neoplasm of kidney and renal pelvis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.1",
            "description": "Secondary malignant neoplasm of bladder and other and unspecified urinary organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.2",
            "description": "Secondary malignant neoplasm of skin",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.6",
            "description": "Secondary malignant neoplasm of ovary",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.8",
            "description": "Secondary malignant neoplasm of other specified sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.9",
            "description": "Secondary malignant neoplasm, unspecified site",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11135,
        "concept_version_id": 18620,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4345",
        "phenotype_version_id": 9563,
        "phenotype_name": "Secondary Malignancy_Other organs",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C78.1",
            "description": "Secondary malignant neoplasm of mediastinum",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C78.3",
            "description": "Secondary malignant neoplasm of other and unspecified respiratory organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C78.8",
            "description": "Secondary malignant neoplasm of other and unspecified digestive organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.0",
            "description": "Secondary malignant neoplasm of kidney and renal pelvis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.1",
            "description": "Secondary malignant neoplasm of bladder and other and unspecified urinary organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.2",
            "description": "Secondary malignant neoplasm of skin",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.6",
            "description": "Secondary malignant neoplasm of ovary",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.8",
            "description": "Secondary malignant neoplasm of other specified sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.9",
            "description": "Secondary malignant neoplasm, unspecified site",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11136,
        "concept_version_id": 18621,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4345",
        "phenotype_version_id": 9563,
        "phenotype_name": "Secondary Malignancy_Other organs",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1D18.00",
            "description": "Pain from metastases",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "5136.00",
            "description": "X-ray metastasis control",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B57..00",
            "description": "Secondary malig neop of respiratory and digestive systems",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B571.00",
            "description": "Secondary malignant neoplasm of mediastinum",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B57..11",
            "description": "Metastases of respiratory and/or digestive systems",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B57..12",
            "description": "Secondary carcinoma of respiratory and/or digestive systems",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B573.00",
            "description": "Secondary malignant neoplasm of other respiratory organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B57y.00",
            "description": "Secondary malignant neoplasm of other digestive organ",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B57z.00",
            "description": "Secondary malig neop of respiratory or digestive system NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58..00",
            "description": "Secondary malignant neoplasm of other specified sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B580.00",
            "description": "Secondary malignant neoplasm of kidney",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B581.00",
            "description": "Secondary malignant neoplasm of other urinary organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B581000",
            "description": "Secondary malignant neoplasm of ureter",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58..11",
            "description": "Secondary carcinoma of other specified sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B581100",
            "description": "Secondary malignant neoplasm of bladder",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B581200",
            "description": "Secondary malignant neoplasm of urethra",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B581z00",
            "description": "Secondary malignant neoplasm of other urinary organ NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B582.00",
            "description": "Secondary malignant neoplasm of skin",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B582000",
            "description": "Secondary malignant neoplasm of skin of head",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B582100",
            "description": "Secondary malignant neoplasm of skin of face",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B582200",
            "description": "Secondary malignant neoplasm of skin of neck",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B582300",
            "description": "Secondary malignant neoplasm of skin of trunk",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B582400",
            "description": "Secondary malignant neoplasm of skin of shoulder and arm",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B582500",
            "description": "Secondary malignant neoplasm of skin of hip and leg",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B582600",
            "description": "Secondary malignant neoplasm of skin of breast",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B582z00",
            "description": "Secondary malignant neoplasm of skin NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B584.00",
            "description": "Secondary malignant neoplasm of other part of nervous system",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B586.00",
            "description": "Secondary malignant neoplasm of ovary",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y.00",
            "description": "Secondary malignant neoplasm of other specified sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y000",
            "description": "Secondary malignant neoplasm of breast",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y100",
            "description": "Secondary malignant neoplasm of uterus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y200",
            "description": "Secondary malignant neoplasm of cervix uteri",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y211",
            "description": "Secondary cancer of the cervix",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y300",
            "description": "Secondary malignant neoplasm of vagina",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y400",
            "description": "Secondary malignant neoplasm of vulva",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y411",
            "description": "Secondary cancer of the vulva",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y500",
            "description": "Secondary malignant neoplasm of prostate",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y600",
            "description": "Secondary malignant neoplasm of testis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y700",
            "description": "Secondary malignant neoplasm of penis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y800",
            "description": "Secondary malignant neoplasm of epididymis and vas deferens",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58y900",
            "description": "Secondary malignant neoplasm of tongue",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58yz",
            "description": "Secondary malignant neoplasm of other specified site NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58yz00",
            "description": "Secondary malignant neoplasm of other specified site NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B58z.00",
            "description": "Secondary malignant neoplasm of other specified site NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B590.00",
            "description": "Disseminated malignancy NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B590.11",
            "description": "Carcinomatosis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "B594.00",
            "description": "Secondary malignant neoplasm of unknown site",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "BB03.00",
            "description": "[M]Neoplasm, metastatic",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "BB03.11",
            "description": "[M]Secondary neoplasm",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "BB13.00",
            "description": "[M]Carcinoma, metastatic, NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "BB13.11",
            "description": "[M]Secondary carcinoma",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "BB2B.00",
            "description": "[M]Squamous cell carcinoma, metastatic NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "BB53.00",
            "description": "[M]Adenocarcinoma, metastatic, NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "BB85100",
            "description": "[M]Metastatic signet ring cell carcinoma",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "BBy2.00",
            "description": "[M]No microscopic confirmation tumour, clinically metastatic",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "ByuC300",
            "description": "[X]Secondary malignant neoplasm/oth+unspc respiratory organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "ByuC400",
            "description": "[X]Secondary malignant neoplasm/oth+unspcfd digestive organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "ByuC500",
            "description": "[X]2ndry malignant neoplasm/bladder+oth+unsp urinary organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "ByuC600",
            "description": "[X]2ndry malignant neoplasm/oth+unspec parts/nervous system",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "ByuC700",
            "description": "[X]Secondary malignant neoplasm of other specified sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaC0y",
            "description": "Secondary malignant neoplasm of tongue",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaFwL",
            "description": "Pain from metastases",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1vm",
            "description": "Secondary malignant neoplasm of respiratory and digestive systems",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1vn",
            "description": "Disseminated malignancy NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE1wR",
            "description": "[M]Neoplasm, metastatic",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE2vT",
            "description": "Secondary malignant neoplasm of other specified sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XM0pv",
            "description": "Secondary malignant neoplasm of unknown site",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11137,
        "concept_version_id": 18622,
        "concept_name": "Type of cancer: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4345",
        "phenotype_version_id": 9563,
        "phenotype_name": "Secondary Malignancy_Other organs",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "C78.1",
            "description": "Secondary malignant neoplasm of mediastinum",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C78.3",
            "description": "Secondary malignant neoplasm of other and unspecified respiratory organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C78.8",
            "description": "Secondary malignant neoplasm of other and unspecified digestive organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.0",
            "description": "Secondary malignant neoplasm of kidney and renal pelvis",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.1",
            "description": "Secondary malignant neoplasm of bladder and other and unspecified urinary organs",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.2",
            "description": "Secondary malignant neoplasm of skin",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.6",
            "description": "Secondary malignant neoplasm of ovary",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.8",
            "description": "Secondary malignant neoplasm of other specified sites",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "C79.9",
            "description": "Secondary malignant neoplasm, unspecified site",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/ab66-h881",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9563,
        "version_name": "Secondary Malignancy_Other organs",
        "version_date": "2026-06-08T20:18:50.956330Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]