[ { "phenotype_id": "PH4366", "phenotype_version_id": 9584, "name": "Stable angina", "definition": "Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:20:14.572190Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:20:14.566486Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Stable angina (disorder)", "value": 649931 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 11251, "concept_version_id": 18736, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4366", "phenotype_version_id": 9584, "phenotype_name": "Stable angina", "code_attribute_header": [ "type" ], "codes": [ { "code": "I20.1", "description": "Angina pectoris with documented spasm", "attributes": { "type": "any" } }, { "code": "I20.8", "description": "Other forms of angina pectoris", "attributes": { "type": "any" } }, { "code": "I20.9", "description": "Angina pectoris, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 11252, "concept_version_id": 18737, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4366", "phenotype_version_id": 9584, "phenotype_name": "Stable angina", "code_attribute_header": [ "type" ], "codes": [ { "code": "I20.1", "description": "Angina pectoris with documented spasm", "attributes": { "type": "any" } }, { "code": "I20.8", "description": "Other forms of angina pectoris", "attributes": { "type": "any" } }, { "code": "I20.9", "description": "Angina pectoris, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 11253, "concept_version_id": 18738, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4366", "phenotype_version_id": 9584, "phenotype_name": "Stable angina", "code_attribute_header": [ "type" ], "codes": [ { "code": "I20.1", "description": "Angina pectoris with documented spasm", "attributes": { "type": "any" } }, { "code": "I20.8", "description": "Other forms of angina pectoris", "attributes": { "type": "any" } }, { "code": "I20.9", "description": "Angina pectoris, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 11254, "concept_version_id": 18739, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4366", "phenotype_version_id": 9584, "phenotype_name": "Stable angina", "code_attribute_header": [ "type" ], "codes": [ { "code": "I20.1", "description": "Angina pectoris with documented spasm", "attributes": { "type": "any" } }, { "code": "I20.8", "description": "Other forms of angina pectoris", "attributes": { "type": "any" } }, { "code": "I20.9", "description": "Angina pectoris, unspecified", "attributes": { "type": "any" } } ] }, { "concept_id": 11255, "concept_version_id": 18740, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4366", "phenotype_version_id": 9584, "phenotype_name": "Stable angina", "code_attribute_header": [ "type" ], "codes": [ { "code": "14A5.00", "description": "H/O: angina pectoris", "attributes": { "type": "prevalent" } }, { "code": "14AJ.00", "description": "H/O: Angina in last year", "attributes": { "type": "prevalent" } }, { "code": "3213100", "description": "Exercise ECG abnormal", "attributes": { "type": "any" } }, { "code": "3213111", "description": "Positive exercise ECG test", "attributes": { "type": "any" } }, { "code": "322..00", "description": "ECG: myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "3222", "description": "ECG:shows myocardial ischaemia", "attributes": { "type": "any" } }, { "code": "322Z.00", "description": "ECG: myocardial ischaemia NOS", "attributes": { "type": "any" } }, { "code": "32E4.00", "description": "ECG: S-T depression", "attributes": { "type": "any" } }, { "code": "32F2.00", "description": "ECG: T wave abnormal", "attributes": { "type": "any" } }, { "code": "32F3.00", "description": "ECG: T wave flattened", "attributes": { "type": "any" } }, { "code": "32F4.00", "description": "ECG: T wave inverted", "attributes": { "type": "any" } }, { "code": "33B9500", "description": "Exercise tolerance test abnormal", "attributes": { "type": "any" } }, { "code": "5543", "description": "Coronary arteriograph.abnormal", "attributes": { "type": "any" } }, { "code": "5C11.00", "description": "Radionuclide heart study abnormal", "attributes": { "type": "any" } }, { "code": "662K.00", "description": "Angina control", "attributes": { "type": "any" } }, { "code": "662K000", "description": "Angina control - good", "attributes": { "type": "any" } }, { "code": "662K100", "description": "Angina control - poor", "attributes": { "type": "any" } }, { "code": "662K200", "description": "Angina control - improving", "attributes": { "type": "any" } }, { "code": "662Kz00", "description": "Angina control NOS", "attributes": { "type": "any" } }, { "code": "7920", "description": "Saphenous vein graft replacement of coronary artery", "attributes": { "type": "any" } }, { "code": "7920000", "description": "Saphenous vein graft replacement of one coronary artery", "attributes": { "type": "any" } }, { "code": "7920100", "description": "Saphenous vein graft replacement of two coronary arteries", "attributes": { "type": "any" } }, { "code": "7920.11", "description": "Saphenous vein graft bypass of coronary artery", "attributes": { "type": "any" } }, { "code": "7920200", "description": "Saphenous vein graft replacement of three coronary arteries", "attributes": { "type": "any" } }, { "code": "7920300", "description": "Saphenous vein graft replacement of four+ coronary arteries", "attributes": { "type": "any" } }, { "code": "7920y00", "description": "Saphenous vein graft replacement of coronary artery OS", "attributes": { "type": "any" } }, { "code": "7920z00", "description": "Saphenous vein graft replacement coronary artery NOS", "attributes": { "type": "any" } }, { "code": "7921", "description": "Other autograft replacement of coronary artery", "attributes": { "type": "any" } }, { "code": "7921000", "description": "Autograft replacement of one coronary artery NEC", "attributes": { "type": "any" } }, { "code": "792..11", "description": "Coronary artery bypass graft operations", "attributes": { "type": "any" } }, { "code": "7921100", "description": "Autograft replacement of two coronary arteries NEC", "attributes": { "type": "any" } }, { "code": "7921.11", "description": "Other autograft bypass of coronary artery", "attributes": { "type": "any" } }, { "code": "7921200", "description": "Autograft replacement of three coronary arteries NEC", "attributes": { "type": "any" } }, { "code": "7921300", "description": "Autograft replacement of four of more coronary arteries NEC", "attributes": { "type": "any" } }, { "code": "7921y00", "description": "Other autograft replacement of coronary artery OS", "attributes": { "type": "any" } }, { "code": "7921z00", "description": "Other autograft replacement of coronary artery NOS", "attributes": { "type": "any" } }, { "code": "7922", "description": "Allograft replacement of coronary artery", "attributes": { "type": "any" } }, { "code": "7922000", "description": "Allograft replacement of one coronary artery", "attributes": { "type": "any" } }, { "code": "7922100", "description": "Allograft replacement of two coronary arteries", "attributes": { "type": "any" } }, { "code": "7922.11", "description": "Allograft bypass of coronary artery", "attributes": { "type": "any" } }, { "code": "7922200", "description": "Allograft replacement of three coronary arteries", "attributes": { "type": "any" } }, { "code": "7922300", "description": "Allograft replacement of four or more coronary arteries", "attributes": { "type": "any" } }, { "code": "7922y00", "description": "Other specified allograft replacement of coronary artery", "attributes": { "type": "any" } }, { "code": "7922z00", "description": "Allograft replacement of coronary artery NOS", "attributes": { "type": "any" } }, { "code": "7923", "description": "Prosthetic replacement of coronary artery", "attributes": { "type": "any" } }, { "code": "7923000", "description": "Prosthetic replacement of one coronary artery", "attributes": { "type": "any" } }, { "code": "7923100", "description": "Prosthetic replacement of two coronary arteries", "attributes": { "type": "any" } }, { "code": "7923.11", "description": "Prosthetic bypass of coronary artery", "attributes": { "type": "any" } }, { "code": "7923200", "description": "Prosthetic replacement of three coronary arteries", "attributes": { "type": "any" } }, { "code": "7923300", "description": "Prosthetic replacement of four or more coronary arteries", "attributes": { "type": "any" } }, { "code": "7923z00", "description": "Prosthetic replacement of coronary artery NOS", "attributes": { "type": "any" } }, { "code": "7925", "description": "Connection of mammary artery to coronary artery", "attributes": { "type": "any" } }, { "code": "7925000", "description": "Double anastomosis of mammary arteries to coronary arteries", "attributes": { "type": "any" } }, { "code": "7925100", "description": "Double implant of mammary arteries into coronary arteries", "attributes": { "type": "any" } }, { "code": "7925.11", "description": "Creation of bypass from mammary artery to coronary artery", "attributes": { "type": "any" } }, { "code": "7925300", "description": "Single anastomosis of mammary artery to coronary artery NEC", "attributes": { "type": "any" } }, { "code": "7925311", "description": "LIMA single anastomosis", "attributes": { "type": "any" } }, { "code": "7925312", "description": "RIMA single anastomosis", "attributes": { "type": "any" } }, { "code": "7925400", "description": "Single implantation of mammary artery into coronary artery", "attributes": { "type": "any" } }, { "code": "7925y00", "description": "Connection of mammary artery to coronary artery OS", "attributes": { "type": "any" } }, { "code": "7925z00", "description": "Connection of mammary artery to coronary artery NOS", "attributes": { "type": "any" } }, { "code": "7926", "description": "Connection of other thoracic artery to coronary artery", "attributes": { "type": "any" } }, { "code": "7926000", "description": "Double anastom thoracic arteries to coronary arteries NEC", "attributes": { "type": "any" } }, { "code": "7926200", "description": "Single anastomosis of thoracic artery to coronary artery NEC", "attributes": { "type": "any" } }, { "code": "7926300", "description": "Single implantation thoracic artery into coronary artery NEC", "attributes": { "type": "any" } }, { "code": "7926z00", "description": "Connection of other thoracic artery to coronary artery NOS", "attributes": { "type": "any" } }, { "code": "7927500", "description": "Open angioplasty of coronary artery", "attributes": { "type": "any" } }, { "code": "7928000", "description": "Percut transluminal balloon angioplasty one coronary artery", "attributes": { "type": "any" } }, { "code": "7928100", "description": "Percut translum balloon angioplasty mult coronary arteries", "attributes": { "type": "any" } }, { "code": "7928.11", "description": "Percutaneous balloon coronary angioplasty", "attributes": { "type": "any" } }, { "code": "7928200", "description": "Percut translum balloon angioplasty bypass graft coronary a", "attributes": { "type": "any" } }, { "code": "7928300", "description": "Percut translum cutting balloon angioplasty coronary artery", "attributes": { "type": "any" } }, { "code": "7928y00", "description": "Transluminal balloon angioplasty of coronary artery OS", "attributes": { "type": "any" } }, { "code": "7928z00", "description": "Transluminal balloon angioplasty of coronary artery NOS", "attributes": { "type": "any" } }, { "code": "7929000", "description": "Percutaneous transluminal laser coronary angioplasty", "attributes": { "type": "any" } }, { "code": "7929300", "description": "Rotary blade coronary angioplasty", "attributes": { "type": "any" } }, { "code": "7929400", "description": "Insertion of coronary artery stent", "attributes": { "type": "any" } }, { "code": "7929500", "description": "Insertion of drug-eluting coronary artery stent", "attributes": { "type": "any" } }, { "code": "7929600", "description": "Percutaneous transluminal atherectomy of coronary artery", "attributes": { "type": "any" } }, { "code": "792B000", "description": "Endarterectomy of coronary artery NEC", "attributes": { "type": "any" } }, { "code": "792C.00", "description": "Other replacement of coronary artery", "attributes": { "type": "any" } }, { "code": "792C000", "description": "Replacement of coronary arteries using multiple methods", "attributes": { "type": "any" } }, { "code": "792Cy00", "description": "Other specified replacement of coronary artery", "attributes": { "type": "any" } }, { "code": "792Cz00", "description": "Replacement of coronary artery NOS", "attributes": { "type": "any" } }, { "code": "792D.00", "description": "Other bypass of coronary artery", "attributes": { "type": "any" } }, { "code": "792Dy00", "description": "Other specified other bypass of coronary artery", "attributes": { "type": "any" } }, { "code": "792Dz00", "description": "Other bypass of coronary artery NOS", "attributes": { "type": "any" } }, { "code": "793G.00", "description": "Perc translumin balloon angioplasty stenting coronary artery", "attributes": { "type": "any" } }, { "code": "793G000", "description": "Perc translum ball angio insert 1-2 drug elut stents cor art", "attributes": { "type": "any" } }, { "code": "793G100", "description": "Perc tran ball angio ins 3 or more drug elut stents cor art", "attributes": { "type": "any" } }, { "code": "793G200", "description": "Perc translum balloon angioplasty insert 1-2 stents cor art", "attributes": { "type": "any" } }, { "code": "793G300", "description": "Percutaneous cor balloon angiop 3 more stents cor art NEC", "attributes": { "type": "any" } }, { "code": "793Gy00", "description": "OS perc translumina balloon angioplast stenting coronary art", "attributes": { "type": "any" } }, { "code": "793Gz00", "description": "Perc translum balloon angioplasty stenting coronary art NOS", "attributes": { "type": "any" } }, { "code": "7A54000", "description": "Percutaneous transluminal angioplasty of artery NEC", "attributes": { "type": "any" } }, { "code": "7A54500", "description": "Rotary blade angioplasty", "attributes": { "type": "any" } }, { "code": "7A54800", "description": "Percutaneous transluminal atherectomy", "attributes": { "type": "any" } }, { "code": "7A56400", "description": "Percutaneous transluminal balloon angioplasty of artery", "attributes": { "type": "any" } }, { "code": "7A6G100", "description": "Peroperative angioplasty", "attributes": { "type": "any" } }, { "code": "7A6H300", "description": "Prosthetic graft patch angioplasty", "attributes": { "type": "any" } }, { "code": "7A6H400", "description": "Percutaneous transluminal angioplasty of vascular graft", "attributes": { "type": "any" } }, { "code": "8B27.00", "description": "Antianginal therapy", "attributes": { "type": "any" } }, { "code": "G33..00", "description": "Angina pectoris", "attributes": { "type": "any" } }, { "code": "G330.00", "description": "Angina decubitus", "attributes": { "type": "any" } }, { "code": "G330000", "description": "Nocturnal angina", "attributes": { "type": "any" } }, { "code": "G330z00", "description": "Angina decubitus NOS", "attributes": { "type": "any" } }, { "code": "G33z.", "description": "Angina pectoris NOS", "attributes": { "type": "any" } }, { "code": "G33z.00", "description": "Angina pectoris NOS", "attributes": { "type": "any" } }, { "code": "G33z100", "description": "Stenocardia", "attributes": { "type": "any" } }, { "code": "G33z200", "description": "Syncope anginosa", "attributes": { "type": "any" } }, { "code": "G33z300", "description": "Angina on effort", "attributes": { "type": "any" } }, { "code": "G33z400", "description": "Ischaemic chest pain", "attributes": { "type": "any" } }, { "code": "G33z500", "description": "Post infarct angina", "attributes": { "type": "any" } }, { "code": "G33z600", "description": "New onset angina", "attributes": { "type": "any" } }, { "code": "G33z700", "description": "Stable angina", "attributes": { "type": "any" } }, { "code": "G33zz00", "description": "Angina pectoris NOS", "attributes": { "type": "any" } }, { "code": "G34y000", "description": "Chronic coronary insufficiency", "attributes": { "type": "any" } }, { "code": "Gyu3000", "description": "[X]Other forms of angina pectoris", "attributes": { "type": "any" } }, { "code": "SP00300", "description": "Mechanical complication of coronary bypass", "attributes": { "type": "any" } }, { "code": "SP07600", "description": "Coronary artery bypass graft occlusion", "attributes": { "type": "any" } }, { "code": "Ua1eH", "description": "Ischaemic chest pain", "attributes": { "type": "any" } }, { "code": "X00tU", "description": "Insertion of coronary artery stent", "attributes": { "type": "any" } }, { "code": "X2008", "description": "Stable angina", "attributes": { "type": "any" } }, { "code": "X200A", "description": "New onset angina", "attributes": { "type": "any" } }, { "code": "X70Wk", "description": "Percutaneous transluminal atherectomy", "attributes": { "type": "any" } }, { "code": "XaBL2", "description": "H/O: Angina in last year", "attributes": { "type": "prevalent" } }, { "code": "XaBLr", "description": "Antianginal therapy", "attributes": { "type": "any" } }, { "code": "XaDyk", "description": "Prosthetic graft patch angioplasty", "attributes": { "type": "any" } }, { "code": "XaDyl", "description": "Percutaneous transluminal angioplasty of vascular graft", "attributes": { "type": "any" } }, { "code": "XaEXt", "description": "Post infarct angina", "attributes": { "type": "any" } }, { "code": "XaJi9", "description": "Radionuclide heart study abnormal", "attributes": { "type": "any" } }, { "code": "XaJIU", "description": "Coronary artery bypass graft occlusion", "attributes": { "type": "any" } }, { "code": "XaLga", "description": "Percutaneous transluminal balloon angioplasty and stenting of coronary artery NOS", "attributes": { "type": "any" } }, { "code": "XaLgU", "description": "Percutaneous transluminal balloon angioplasty and stenting of coronary artery", "attributes": { "type": "any" } }, { "code": "XaLgV", "description": "Percutaneous transluminal balloon angioplasty and insertion of 1-2 drug eluting stents into coronary artery", "attributes": { "type": "any" } }, { "code": "XaLgW", "description": "Percutaneous transluminal balloon angioplasty and insertion of 3 or more drug eluting stents into coronary artery", "attributes": { "type": "any" } }, { "code": "XaLgX", "description": "Percutaneous transluminal balloon angioplasty and insertion of 1-2 stents into coronary artery", "attributes": { "type": "any" } }, { "code": "XaLgY", "description": "Percutaneous coronary balloon angioplasty and 3 or more stents into coronary artery NEC", "attributes": { "type": "any" } }, { "code": "XaLgZ", "description": "Other specified percutaneous transluminal balloon angioplasty and stenting of coronary artery", "attributes": { "type": "any" } }, { "code": "XaLhc", "description": "Percutaneous transluminal balloon angioplasty of artery", "attributes": { "type": "any" } }, { "code": "XaLSD", "description": "Insertion of drug-eluting coronary artery stent", "attributes": { "type": "any" } }, { "code": "XaMKE", "description": "Percutaneous transluminal cutting balloon angioplasty of coronary artery", "attributes": { "type": "any" } }, { "code": "XE0En", "description": "Double anastomosis of mammary arteries to coronary arteries", "attributes": { "type": "any" } }, { "code": "XE2Px", "description": "Single anastomosis of mammary artery to coronary artery NEC", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/64p5-g165", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9584, "version_name": "Stable angina", "version_date": "2026-06-08T20:20:14.588247Z", "is_published": true, "is_latest": true } ] } ]