[ { "phenotype_id": "PH4367", "phenotype_version_id": 9585, "name": "Stroke NOS", "definition": "A group of pathological conditions characterized by sudden, non\\-convulsive loss of neurological function due to brain ischemia or intracranial hemorrhages.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:20:21.074243Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:20:21.068475Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Cerebrovascular accident (disorder)", "value": 687298 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 11256, "concept_version_id": 18741, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4367", "phenotype_version_id": 9585, "phenotype_name": "Stroke NOS", "code_attribute_header": [ "type" ], "codes": [ { "code": "G46.3", "description": "Brain stem stroke syndrome", "attributes": { "type": "any" } }, { "code": "G46.4", "description": "Cerebellar stroke syndrome", "attributes": { "type": "any" } }, { "code": "G46.5", "description": "Pure motor lacunar syndrome", "attributes": { "type": "any" } }, { "code": "G46.6", "description": "Pure sensory lacunar syndrome", "attributes": { "type": "any" } }, { "code": "G46.7", "description": "Other lacunar syndromes", "attributes": { "type": "any" } }, { "code": "G46.8", "description": "Other vascular syndromes of brain in cerebrovascular diseases", "attributes": { "type": "any" } }, { "code": "I64", "description": "Stroke, not specified as haemorrhage or infarction", "attributes": { "type": "any" } }, { "code": "I69.4", "description": "Sequelae of stroke, not specified as haemorrhage or infarction", "attributes": { "type": "prevalent" } } ] }, { "concept_id": 11257, "concept_version_id": 18742, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4367", "phenotype_version_id": 9585, "phenotype_name": "Stroke NOS", "code_attribute_header": [ "type" ], "codes": [ { "code": "G46.3", "description": "Brain stem stroke syndrome", "attributes": { "type": "any" } }, { "code": "G46.4", "description": "Cerebellar stroke syndrome", "attributes": { "type": "any" } }, { "code": "G46.5", "description": "Pure motor lacunar syndrome", "attributes": { "type": "any" } }, { "code": "G46.6", "description": "Pure sensory lacunar syndrome", "attributes": { "type": "any" } }, { "code": "G46.7", "description": "Other lacunar syndromes", "attributes": { "type": "any" } }, { "code": "G46.8", "description": "Other vascular syndromes of brain in cerebrovascular diseases", "attributes": { "type": "any" } }, { "code": "I64", "description": "Stroke, not specified as haemorrhage or infarction", "attributes": { "type": "any" } }, { "code": "I69.4", "description": "Sequelae of stroke, not specified as haemorrhage or infarction", "attributes": { "type": "prevalent" } } ] }, { "concept_id": 11258, "concept_version_id": 18743, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4367", "phenotype_version_id": 9585, "phenotype_name": "Stroke NOS", "code_attribute_header": [ "type" ], "codes": [ { "code": "G46.3", "description": "Brain stem stroke syndrome", "attributes": { "type": "any" } }, { "code": "G46.4", "description": "Cerebellar stroke syndrome", "attributes": { "type": "any" } }, { "code": "G46.5", "description": "Pure motor lacunar syndrome", "attributes": { "type": "any" } }, { "code": "G46.6", "description": "Pure sensory lacunar syndrome", "attributes": { "type": "any" } }, { "code": "G46.7", "description": "Other lacunar syndromes", "attributes": { "type": "any" } }, { "code": "G46.8", "description": "Other vascular syndromes of brain in cerebrovascular diseases", "attributes": { "type": "any" } }, { "code": "I64", "description": "Stroke, not specified as haemorrhage or infarction", "attributes": { "type": "any" } }, { "code": "I69.4", "description": "Sequelae of stroke, not specified as haemorrhage or infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 11259, "concept_version_id": 18744, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4367", "phenotype_version_id": 9585, "phenotype_name": "Stroke NOS", "code_attribute_header": [ "type" ], "codes": [ { "code": "G46.3", "description": "Brain stem stroke syndrome", "attributes": { "type": "any" } }, { "code": "G46.4", "description": "Cerebellar stroke syndrome", "attributes": { "type": "any" } }, { "code": "G46.5", "description": "Pure motor lacunar syndrome", "attributes": { "type": "any" } }, { "code": "G46.6", "description": "Pure sensory lacunar syndrome", "attributes": { "type": "any" } }, { "code": "G46.7", "description": "Other lacunar syndromes", "attributes": { "type": "any" } }, { "code": "G46.8", "description": "Other vascular syndromes of brain in cerebrovascular diseases", "attributes": { "type": "any" } }, { "code": "I64", "description": "Stroke, not specified as haemorrhage or infarction", "attributes": { "type": "any" } }, { "code": "I69.4", "description": "Sequelae of stroke, not specified as haemorrhage or infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 11260, "concept_version_id": 18745, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4367", "phenotype_version_id": 9585, "phenotype_name": "Stroke NOS", "code_attribute_header": [ "type" ], "codes": [ { "code": "14A7.00", "description": "H/O: CVA/stroke", "attributes": { "type": "prevalent" } }, { "code": "14A7.11", "description": "H/O: CVA", "attributes": { "type": "prevalent" } }, { "code": "14A7.12", "description": "H/O: stroke", "attributes": { "type": "prevalent" } }, { "code": "14AK.00", "description": "H/O: Stroke in last year", "attributes": { "type": "prevalent" } }, { "code": "1M4..00", "description": "Central post-stroke pain", "attributes": { "type": "any" } }, { "code": "661M700", "description": "Stroke self-management plan agreed", "attributes": { "type": "any" } }, { "code": "661N700", "description": "Stroke self-management plan review", "attributes": { "type": "prevalent" } }, { "code": "662e.00", "description": "Stroke/CVA annual review", "attributes": { "type": "prevalent" } }, { "code": "662e.11", "description": "Stroke annual review", "attributes": { "type": "prevalent" } }, { "code": "662M.00", "description": "Stroke monitoring", "attributes": { "type": "prevalent" } }, { "code": "662M100", "description": "Stroke 6 month review", "attributes": { "type": "prevalent" } }, { "code": "662M200", "description": "Stroke initial post discharge review", "attributes": { "type": "prevalent" } }, { "code": "7P24200", "description": "Delivery of rehabilitation for stroke", "attributes": { "type": "any" } }, { "code": "8HHM.00", "description": "Ref to multidisciplinary stroke function improvement service", "attributes": { "type": "any" } }, { "code": "8IEC.00", "description": "Ref multidisciplinary stroke function improvement declined", "attributes": { "type": "any" } }, { "code": "9h2..00", "description": "Exception reporting: stroke quality indicators", "attributes": { "type": "prevalent" } }, { "code": "9h21.00", "description": "Excepted from stroke quality indicators: Patient unsuitable", "attributes": { "type": "prevalent" } }, { "code": "9h22.00", "description": "Excepted from stroke quality indicators: Informed dissent", "attributes": { "type": "prevalent" } }, { "code": "Fyu5600", "description": "[X]Other lacunar syndromes", "attributes": { "type": "any" } }, { "code": "G66..00", "description": "Stroke and cerebrovascular accident unspecified", "attributes": { "type": "any" } }, { "code": "G66..11", "description": "CVA unspecified", "attributes": { "type": "any" } }, { "code": "G66..12", "description": "Stroke unspecified", "attributes": { "type": "any" } }, { "code": "G66..13", "description": "CVA - Cerebrovascular accident unspecified", "attributes": { "type": "any" } }, { "code": "G663.00", "description": "Brain stem stroke syndrome", "attributes": { "type": "any" } }, { "code": "G664.00", "description": "Cerebellar stroke syndrome", "attributes": { "type": "any" } }, { "code": "G665.00", "description": "Pure motor lacunar syndrome", "attributes": { "type": "any" } }, { "code": "G666.00", "description": "Pure sensory lacunar syndrome", "attributes": { "type": "any" } }, { "code": "G667.00", "description": "Left sided CVA", "attributes": { "type": "any" } }, { "code": "G668.00", "description": "Right sided CVA", "attributes": { "type": "any" } }, { "code": "G68X.00", "description": "Sequelae of stroke,not specfd as h'morrhage or infarction", "attributes": { "type": "prevalent" } }, { "code": "Gyu6C00", "description": "[X]Sequelae of stroke,not specfd as h'morrhage or infarction", "attributes": { "type": "prevalent" } }, { "code": "L440.11", "description": "CVA - cerebrovascular accident in the puerperium", "attributes": { "type": "any" } }, { "code": "L440.12", "description": "Stroke in the puerperium", "attributes": { "type": "any" } }, { "code": "Xa0Ml", "description": "Central post-stroke pain", "attributes": { "type": "any" } }, { "code": "XaBL3", "description": "H/O: Stroke in last year", "attributes": { "type": "prevalent" } }, { "code": "XaIzF", "description": "Stroke/CVA annual review", "attributes": { "type": "prevalent" } }, { "code": "XaJ4b", "description": "Excepted from stroke quality indicators: Patient unsuitable", "attributes": { "type": "prevalent" } }, { "code": "XaJ4c", "description": "Excepted from stroke quality indicators: Informed dissent", "attributes": { "type": "prevalent" } }, { "code": "XaJ4O", "description": "Exception reporting: stroke quality indicators", "attributes": { "type": "prevalent" } }, { "code": "XaJi5", "description": "Referral to multidisciplinary stroke function improvement service", "attributes": { "type": "any" } }, { "code": "XaLtA", "description": "Delivery of rehabilitation for stroke", "attributes": { "type": "any" } }, { "code": "XaQbK", "description": "Pure motor lacunar syndrome", "attributes": { "type": "any" } }, { "code": "XaQbM", "description": "Pure sensory lacunar syndrome", "attributes": { "type": "any" } }, { "code": "XaR68", "description": "Stroke 6 month review", "attributes": { "type": "prevalent" } }, { "code": "XaXlL", "description": "Referral for multidisciplinary stroke function improvement declined", "attributes": { "type": "any" } }, { "code": "XaYbE", "description": "Stroke self-management plan agreed", "attributes": { "type": "any" } }, { "code": "XaYm4", "description": "Stroke initial post discharge review", "attributes": { "type": "prevalent" } }, { "code": "XaYZQ", "description": "Stroke self-management plan review", "attributes": { "type": "prevalent" } }, { "code": "XE2aB", "description": "Stroke and cerebrovascular accident unspecified", "attributes": { "type": "any" } }, { "code": "XE2sl", "description": "Cerebrovascular disorders in the puerperium", "attributes": { "type": "any" } }, { "code": "XE2te", "description": "H/O: CVA/stroke", "attributes": { "type": "prevalent" } }, { "code": "ZV12511", "description": "[V]Personal history of stroke", "attributes": { "type": "prevalent" } }, { "code": "ZV12512", "description": "[V]Personal history of cerebrovascular accident (CVA)", "attributes": { "type": "prevalent" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/3k49-me62", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9585, "version_name": "Stroke NOS", "version_date": "2026-06-08T20:20:21.084595Z", "is_published": true, "is_latest": true } ] } ]