[ { "phenotype_id": "PH4379", "phenotype_version_id": 9597, "name": "Transient ischaemic attack", "definition": "A transient ischaemic attack (TIA) or \"mini stroke\" is caused by a temporary disruption in the blood supply to part of the brain.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:21:19.513574Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:21:19.505831Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Transient ischemic attack (disorder)", "value": 488326 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 11326, "concept_version_id": 18811, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4379", "phenotype_version_id": 9597, "phenotype_name": "Transient ischaemic attack", "code_attribute_header": [ "type" ], "codes": [ { "code": "1082", "description": "transient ischaemic attack (tia)", "attributes": { "type": "any" } } ] }, { "concept_id": 11327, "concept_version_id": 18812, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4379", "phenotype_version_id": 9597, "phenotype_name": "Transient ischaemic attack", "code_attribute_header": [ "type" ], "codes": [ { "code": "G45.0", "description": "Vertebro-basilar artery syndrome", "attributes": { "type": "any" } }, { "code": "G45.1", "description": "Carotid artery syndrome (hemispheric)", "attributes": { "type": "any" } }, { "code": "G45.2", "description": "Multiple and bilateral precerebral artery syndromes", "attributes": { "type": "any" } }, { "code": "G45.3", "description": "Amaurosis fugax", "attributes": { "type": "any" } }, { "code": "G45.4", "description": "Transient global amnesia", "attributes": { "type": "any" } }, { "code": "G45.8", "description": "Other transient cerebral ischaemic attacks and related syndromes", "attributes": { "type": "any" } }, { "code": "G45.9", "description": "Transient cerebral ischaemic attack, unspecified", "attributes": { "type": "any" } }, { "code": "G46.0", "description": "Middle cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "G46.1", "description": "Anterior cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "G46.2", "description": "Posterior cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "I65", "description": "Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction", "attributes": { "type": "any" } }, { "code": "I66", "description": "Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 11328, "concept_version_id": 18813, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4379", "phenotype_version_id": 9597, "phenotype_name": "Transient ischaemic attack", "code_attribute_header": [ "type" ], "codes": [ { "code": "G45.0", "description": "Vertebro-basilar artery syndrome", "attributes": { "type": "any" } }, { "code": "G45.1", "description": "Carotid artery syndrome (hemispheric)", "attributes": { "type": "any" } }, { "code": "G45.2", "description": "Multiple and bilateral precerebral artery syndromes", "attributes": { "type": "any" } }, { "code": "G45.3", "description": "Amaurosis fugax", "attributes": { "type": "any" } }, { "code": "G45.4", "description": "Transient global amnesia", "attributes": { "type": "any" } }, { "code": "G45.8", "description": "Other transient cerebral ischaemic attacks and related syndromes", "attributes": { "type": "any" } }, { "code": "G45.9", "description": "Transient cerebral ischaemic attack, unspecified", "attributes": { "type": "any" } }, { "code": "G46.0", "description": "Middle cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "G46.1", "description": "Anterior cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "G46.2", "description": "Posterior cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "I65", "description": "Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction", "attributes": { "type": "any" } }, { "code": "I66", "description": "Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 11329, "concept_version_id": 18814, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4379", "phenotype_version_id": 9597, "phenotype_name": "Transient ischaemic attack", "code_attribute_header": [ "type" ], "codes": [ { "code": "G45.0", "description": "Vertebro-basilar artery syndrome", "attributes": { "type": "any" } }, { "code": "G45.1", "description": "Carotid artery syndrome (hemispheric)", "attributes": { "type": "any" } }, { "code": "G45.2", "description": "Multiple and bilateral precerebral artery syndromes", "attributes": { "type": "any" } }, { "code": "G45.3", "description": "Amaurosis fugax", "attributes": { "type": "any" } }, { "code": "G45.4", "description": "Transient global amnesia", "attributes": { "type": "any" } }, { "code": "G45.8", "description": "Other transient cerebral ischaemic attacks and related syndromes", "attributes": { "type": "any" } }, { "code": "G45.9", "description": "Transient cerebral ischaemic attack, unspecified", "attributes": { "type": "any" } }, { "code": "G46.0", "description": "Middle cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "G46.1", "description": "Anterior cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "G46.2", "description": "Posterior cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "I65", "description": "Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction", "attributes": { "type": "any" } }, { "code": "I66", "description": "Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 11330, "concept_version_id": 18815, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4379", "phenotype_version_id": 9597, "phenotype_name": "Transient ischaemic attack", "code_attribute_header": [ "type" ], "codes": [ { "code": "G45.0", "description": "Vertebro-basilar artery syndrome", "attributes": { "type": "any" } }, { "code": "G45.1", "description": "Carotid artery syndrome (hemispheric)", "attributes": { "type": "any" } }, { "code": "G45.2", "description": "Multiple and bilateral precerebral artery syndromes", "attributes": { "type": "any" } }, { "code": "G45.3", "description": "Amaurosis fugax", "attributes": { "type": "any" } }, { "code": "G45.4", "description": "Transient global amnesia", "attributes": { "type": "any" } }, { "code": "G45.8", "description": "Other transient cerebral ischaemic attacks and related syndromes", "attributes": { "type": "any" } }, { "code": "G45.9", "description": "Transient cerebral ischaemic attack, unspecified", "attributes": { "type": "any" } }, { "code": "G46.0", "description": "Middle cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "G46.1", "description": "Anterior cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "G46.2", "description": "Posterior cerebral artery syndrome", "attributes": { "type": "any" } }, { "code": "I65", "description": "Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction", "attributes": { "type": "any" } }, { "code": "I66", "description": "Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction", "attributes": { "type": "any" } } ] }, { "concept_id": 11331, "concept_version_id": 18816, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4379", "phenotype_version_id": 9597, "phenotype_name": "Transient ischaemic attack", "code_attribute_header": [ "type" ], "codes": [ { "code": "14AB.00", "description": "H/O: TIA", "attributes": { "type": "prevalent" } }, { "code": "14AB000", "description": "H/O amaurosis fugax", "attributes": { "type": "prevalent" } }, { "code": "1B1S.00", "description": "Transient global amnesia", "attributes": { "type": "any" } }, { "code": "8CRB.00", "description": "Transient ischaemic attack clinical management plan", "attributes": { "type": "any" } }, { "code": "F423600", "description": "Amaurosis fugax", "attributes": { "type": "any" } }, { "code": "Fyu5500", "description": "[X]Other transnt cerebral ischaemic attacks+related syndroms", "attributes": { "type": "any" } }, { "code": "G65..00", "description": "Transient cerebral ischaemia", "attributes": { "type": "any" } }, { "code": "G650.11", "description": "Insufficiency - basilar artery", "attributes": { "type": "any" } }, { "code": "G65..12", "description": "Transient ischaemic attack", "attributes": { "type": "any" } }, { "code": "G65..13", "description": "Vertebro-basilar insufficiency", "attributes": { "type": "any" } }, { "code": "G655.00", "description": "Transient global amnesia", "attributes": { "type": "any" } }, { "code": "G656.00", "description": "Vertebrobasilar insufficiency", "attributes": { "type": "any" } }, { "code": "G657.00", "description": "Carotid territory transient ischaemic attack", "attributes": { "type": "any" } }, { "code": "G65y.00", "description": "Other transient cerebral ischaemia", "attributes": { "type": "any" } }, { "code": "G65z.", "description": "Transient cerebral ischaemia NOS", "attributes": { "type": "any" } }, { "code": "G65z.00", "description": "Transient cerebral ischaemia NOS", "attributes": { "type": "any" } }, { "code": "G65z100", "description": "Intermittent cerebral ischaemia", "attributes": { "type": "any" } }, { "code": "G65zz00", "description": "Transient cerebral ischaemia NOS", "attributes": { "type": "any" } }, { "code": "X00DU", "description": "Carotid territory transient ischaemic attack", "attributes": { "type": "any" } }, { "code": "X00DW", "description": "Vertebrobasilar insufficiency", "attributes": { "type": "any" } }, { "code": "X00E2", "description": "Transient global amnesia", "attributes": { "type": "any" } }, { "code": "XaQve", "description": "Transient ischaemic attack clinical management plan", "attributes": { "type": "any" } }, { "code": "XaX16", "description": "[V]Personal history of transient ischaemic attack", "attributes": { "type": "prevalent" } }, { "code": "XaZIY", "description": "H/O amaurosis fugax", "attributes": { "type": "prevalent" } }, { "code": "Z7CE700", "description": "Transient global amnesia", "attributes": { "type": "any" } }, { "code": "Z7CE711", "description": "TGA - Transient global amnesia", "attributes": { "type": "any" } }, { "code": "ZV12D00", "description": "[V]Personal history of transient ischaemic attack", "attributes": { "type": "prevalent" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/55v1-6m19", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9597, "version_name": "Transient ischaemic attack", "version_date": "2026-06-08T20:21:19.525081Z", "is_published": true, "is_latest": true } ] } ]