[ { "phenotype_id": "PH4380", "phenotype_version_id": 9598, "name": "Tubulo-interstitial nephritis", "definition": "Primary inflammation of tubules in the interstitial tissue of the kidney.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:21:23.384718Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:21:23.377415Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Tubulointerstitial nephritis (disorder)", "value": 239799 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 11332, "concept_version_id": 18817, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4380", "phenotype_version_id": 9598, "phenotype_name": "Tubulo-interstitial nephritis", "code_attribute_header": [ "type" ], "codes": [ { "code": "1515", "description": "pyelonephritis", "attributes": { "type": "any" } } ] }, { "concept_id": 11333, "concept_version_id": 18818, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4380", "phenotype_version_id": 9598, "phenotype_name": "Tubulo-interstitial nephritis", "code_attribute_header": [ "type" ], "codes": [ { "code": "N12", "description": "Tubulo-interstitial nephritis, not specified as acute or chronic", "attributes": { "type": "any" } }, { "code": "N14.0", "description": "Analgesic nephropathy", "attributes": { "type": "any" } }, { "code": "N14.1", "description": "Nephropathy induced by other drugs, medicaments and biological substances", "attributes": { "type": "any" } }, { "code": "N14.2", "description": "Nephropathy induced by unspecified drug, medicament or biological substance", "attributes": { "type": "any" } }, { "code": "N14.3", "description": "Nephropathy induced by heavy metals", "attributes": { "type": "any" } }, { "code": "N14.4", "description": "Toxic nephropathy, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "N15.8", "description": "Other specified renal tubulo-interstitial diseases", "attributes": { "type": "any" } }, { "code": "N15.9", "description": "Renal tubulo-interstitial disease, unspecified", "attributes": { "type": "any" } }, { "code": "N16.1", "description": "Renal tubulo-interstitial disorders in neoplastic diseases", "attributes": { "type": "any" } }, { "code": "N16.2", "description": "Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism", "attributes": { "type": "any" } }, { "code": "N16.3", "description": "Renal tubulo-interstitial disorders in metabolic diseases", "attributes": { "type": "any" } }, { "code": "N16.4", "description": "Renal tubulo-interstitial disorders in systemic connective tissue disorders", "attributes": { "type": "any" } }, { "code": "N16.5", "description": "Renal tubulo-interstitial disorders in transplant rejection", "attributes": { "type": "any" } }, { "code": "N16.8", "description": "Renal tubulo-interstitial disorders in other diseases classified elsewhere", "attributes": { "type": "any" } } ] }, { "concept_id": 11334, "concept_version_id": 18819, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4380", "phenotype_version_id": 9598, "phenotype_name": "Tubulo-interstitial nephritis", "code_attribute_header": [ "type" ], "codes": [ { "code": "N12", "description": "Tubulo-interstitial nephritis, not specified as acute or chronic", "attributes": { "type": "any" } }, { "code": "N14.0", "description": "Analgesic nephropathy", "attributes": { "type": "any" } }, { "code": "N14.1", "description": "Nephropathy induced by other drugs, medicaments and biological substances", "attributes": { "type": "any" } }, { "code": "N14.2", "description": "Nephropathy induced by unspecified drug, medicament or biological substance", "attributes": { "type": "any" } }, { "code": "N14.3", "description": "Nephropathy induced by heavy metals", "attributes": { "type": "any" } }, { "code": "N14.4", "description": "Toxic nephropathy, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "N15.8", "description": "Other specified renal tubulo-interstitial diseases", "attributes": { "type": "any" } }, { "code": "N15.9", "description": "Renal tubulo-interstitial disease, unspecified", "attributes": { "type": "any" } }, { "code": "N16.1", "description": "Renal tubulo-interstitial disorders in neoplastic diseases", "attributes": { "type": "any" } }, { "code": "N16.2", "description": "Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism", "attributes": { "type": "any" } }, { "code": "N16.3", "description": "Renal tubulo-interstitial disorders in metabolic diseases", "attributes": { "type": "any" } }, { "code": "N16.4", "description": "Renal tubulo-interstitial disorders in systemic connective tissue disorders", "attributes": { "type": "any" } }, { "code": "N16.5", "description": "Renal tubulo-interstitial disorders in transplant rejection", "attributes": { "type": "any" } }, { "code": "N16.8", "description": "Renal tubulo-interstitial disorders in other diseases classified elsewhere", "attributes": { "type": "any" } } ] }, { "concept_id": 11335, "concept_version_id": 18820, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4380", "phenotype_version_id": 9598, "phenotype_name": "Tubulo-interstitial nephritis", "code_attribute_header": [ "type" ], "codes": [ { "code": "N12", "description": "Tubulo-interstitial nephritis, not specified as acute or chronic", "attributes": { "type": "any" } }, { "code": "N14.0", "description": "Analgesic nephropathy", "attributes": { "type": "any" } }, { "code": "N14.1", "description": "Nephropathy induced by other drugs, medicaments and biological substances", "attributes": { "type": "any" } }, { "code": "N14.2", "description": "Nephropathy induced by unspecified drug, medicament or biological substance", "attributes": { "type": "any" } }, { "code": "N14.3", "description": "Nephropathy induced by heavy metals", "attributes": { "type": "any" } }, { "code": "N14.4", "description": "Toxic nephropathy, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "N15.8", "description": "Other specified renal tubulo-interstitial diseases", "attributes": { "type": "any" } }, { "code": "N15.9", "description": "Renal tubulo-interstitial disease, unspecified", "attributes": { "type": "any" } }, { "code": "N16.1", "description": "Renal tubulo-interstitial disorders in neoplastic diseases", "attributes": { "type": "any" } }, { "code": "N16.2", "description": "Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism", "attributes": { "type": "any" } }, { "code": "N16.3", "description": "Renal tubulo-interstitial disorders in metabolic diseases", "attributes": { "type": "any" } }, { "code": "N16.4", "description": "Renal tubulo-interstitial disorders in systemic connective tissue disorders", "attributes": { "type": "any" } }, { "code": "N16.5", "description": "Renal tubulo-interstitial disorders in transplant rejection", "attributes": { "type": "any" } }, { "code": "N16.8", "description": "Renal tubulo-interstitial disorders in other diseases classified elsewhere", "attributes": { "type": "any" } } ] }, { "concept_id": 11336, "concept_version_id": 18821, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4380", "phenotype_version_id": 9598, "phenotype_name": "Tubulo-interstitial nephritis", "code_attribute_header": [ "type" ], "codes": [ { "code": "N12", "description": "Tubulo-interstitial nephritis, not specified as acute or chronic", "attributes": { "type": "any" } }, { "code": "N14.0", "description": "Analgesic nephropathy", "attributes": { "type": "any" } }, { "code": "N14.1", "description": "Nephropathy induced by other drugs, medicaments and biological substances", "attributes": { "type": "any" } }, { "code": "N14.2", "description": "Nephropathy induced by unspecified drug, medicament or biological substance", "attributes": { "type": "any" } }, { "code": "N14.3", "description": "Nephropathy induced by heavy metals", "attributes": { "type": "any" } }, { "code": "N14.4", "description": "Toxic nephropathy, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "N15.8", "description": "Other specified renal tubulo-interstitial diseases", "attributes": { "type": "any" } }, { "code": "N15.9", "description": "Renal tubulo-interstitial disease, unspecified", "attributes": { "type": "any" } }, { "code": "N16.1", "description": "Renal tubulo-interstitial disorders in neoplastic diseases", "attributes": { "type": "any" } }, { "code": "N16.2", "description": "Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism", "attributes": { "type": "any" } }, { "code": "N16.3", "description": "Renal tubulo-interstitial disorders in metabolic diseases", "attributes": { "type": "any" } }, { "code": "N16.4", "description": "Renal tubulo-interstitial disorders in systemic connective tissue disorders", "attributes": { "type": "any" } }, { "code": "N16.5", "description": "Renal tubulo-interstitial disorders in transplant rejection", "attributes": { "type": "any" } }, { "code": "N16.8", "description": "Renal tubulo-interstitial disorders in other diseases classified elsewhere", "attributes": { "type": "any" } } ] }, { "concept_id": 11337, "concept_version_id": 18822, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4380", "phenotype_version_id": 9598, "phenotype_name": "Tubulo-interstitial nephritis", "code_attribute_header": [ "type" ], "codes": [ { "code": "K03T.00", "description": "Tubulo-interstit nephritis, not specif as acute or chron", "attributes": { "type": "any" } }, { "code": "K03y200", "description": "Other interstitial nephritis", "attributes": { "type": "any" } }, { "code": "K0B..00", "description": "Renal tubulo-interstitial disorders in diseases EC", "attributes": { "type": "any" } }, { "code": "K0B1.00", "description": "Renal tubulo-interstitial disorder/ neoplastic diseases", "attributes": { "type": "any" } }, { "code": "K0B2.00", "description": "Ren tub-interst disordr/blood dis+disordr inv immune mech", "attributes": { "type": "any" } }, { "code": "K0B4.00", "description": "Ren tub-interstitl disordr/systemc connectv tiss disorder", "attributes": { "type": "any" } }, { "code": "K0B4000", "description": "Renal tubulo-interstitial disorder in SLE", "attributes": { "type": "any" } }, { "code": "K0B5.00", "description": "Renal tubulo-interstitial disordrs in transplant rejectn", "attributes": { "type": "any" } }, { "code": "K0C..00", "description": "Drug/heavy-metal-induced tubulo-interstitial and tub conditn", "attributes": { "type": "any" } }, { "code": "K0C0.00", "description": "Analgesic nephropathy", "attributes": { "type": "any" } }, { "code": "K0C1.00", "description": "Nephropathy induced by other drugs meds and biologl substncs", "attributes": { "type": "any" } }, { "code": "K0C2.00", "description": "Nephropathy induced by unspec drug medicament or biol subs", "attributes": { "type": "any" } }, { "code": "K0C4.00", "description": "Toxic nephropathy, not elsewhere classified", "attributes": { "type": "any" } }, { "code": "K0C5.00", "description": "Acute drug-induced interstitial nephritis", "attributes": { "type": "any" } }, { "code": "K0C6.00", "description": "Chronic lithium nephrotoxicity", "attributes": { "type": "any" } }, { "code": "Kyu1.00", "description": "[X]Renal tubulo-interstitial diseases", "attributes": { "type": "any" } }, { "code": "Kyu1000", "description": "[X]Other chronic tubulo-interstitial nephritis", "attributes": { "type": "any" } }, { "code": "Kyu1400", "description": "[X]Nephropathy induced by other drugs+biological substances", "attributes": { "type": "any" } }, { "code": "Kyu1E00", "description": "[X]Tubulo-interstit nephritis, not specif as acute or chron", "attributes": { "type": "any" } }, { "code": "X30JM", "description": "Acute drug-induced interstitial nephritis", "attributes": { "type": "any" } }, { "code": "X30JS", "description": "Analgesic nephropathy", "attributes": { "type": "any" } }, { "code": "X30LN", "description": "Chronic lithium nephrotoxicity", "attributes": { "type": "any" } }, { "code": "XaBE1", "description": "Renal tubulo-interstitial disorder in systemic lupus erythematosus", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/ezt1-rw30", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9598, "version_name": "Tubulo-interstitial nephritis", "version_date": "2026-06-08T20:21:23.399981Z", "is_published": true, "is_latest": true } ] } ]