[ { "phenotype_id": "PH4390", "phenotype_version_id": 9608, "name": "Urticaria", "definition": "A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:22:07.743455Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:22:07.734588Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Urticaria (disorder)", "value": 237531 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 11395, "concept_version_id": 18880, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4390", "phenotype_version_id": 9608, "phenotype_name": "Urticaria", "code_attribute_header": [ "type" ], "codes": [ { "code": "1563", "description": "urticaria", "attributes": { "type": "any" } } ] }, { "concept_id": 11396, "concept_version_id": 18881, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4390", "phenotype_version_id": 9608, "phenotype_name": "Urticaria", "code_attribute_header": [ "type" ], "codes": [ { "code": "L50", "description": "Urticaria", "attributes": { "type": "any" } } ] }, { "concept_id": 11397, "concept_version_id": 18882, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4390", "phenotype_version_id": 9608, "phenotype_name": "Urticaria", "code_attribute_header": [ "type" ], "codes": [ { "code": "L50", "description": "Urticaria", "attributes": { "type": "any" } } ] }, { "concept_id": 11398, "concept_version_id": 18883, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4390", "phenotype_version_id": 9608, "phenotype_name": "Urticaria", "code_attribute_header": [ "type" ], "codes": [ { "code": "L50", "description": "Urticaria", "attributes": { "type": "any" } } ] }, { "concept_id": 11399, "concept_version_id": 18884, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4390", "phenotype_version_id": 9608, "phenotype_name": "Urticaria", "code_attribute_header": [ "type" ], "codes": [ { "code": "L50", "description": "Urticaria", "attributes": { "type": "any" } } ] }, { "concept_id": 11400, "concept_version_id": 18885, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4390", "phenotype_version_id": 9608, "phenotype_name": "Urticaria", "code_attribute_header": [ "type" ], "codes": [ { "code": "2F8..", "description": "O/E - weals present", "attributes": { "type": "any" } }, { "code": "2F8..00", "description": "O/E - weals present", "attributes": { "type": "any" } }, { "code": "2F82.00", "description": "O/E - weals present", "attributes": { "type": "any" } }, { "code": "2F8Z.00", "description": "O/E - weals NOS", "attributes": { "type": "any" } }, { "code": "M12A200", "description": "Solar urticaria", "attributes": { "type": "any" } }, { "code": "M28..00", "description": "Urticaria", "attributes": { "type": "any" } }, { "code": "M280.00", "description": "Allergic urticaria", "attributes": { "type": "any" } }, { "code": "M280.11", "description": "Drug induced urticaria", "attributes": { "type": "any" } }, { "code": "M281.00", "description": "Idiopathic urticaria", "attributes": { "type": "any" } }, { "code": "M282.00", "description": "Urticaria due to cold and heat", "attributes": { "type": "any" } }, { "code": "M282000", "description": "Cold urticaria", "attributes": { "type": "any" } }, { "code": "M282100", "description": "Thermal urticaria", "attributes": { "type": "any" } }, { "code": "M282111", "description": "Heat urticaria", "attributes": { "type": "any" } }, { "code": "M282z00", "description": "Urticaria due to cold and heat NOS", "attributes": { "type": "any" } }, { "code": "M283.00", "description": "Dermatographic urticaria", "attributes": { "type": "any" } }, { "code": "M283.11", "description": "Factitial urticaria", "attributes": { "type": "any" } }, { "code": "M284.00", "description": "Vibratory urticaria", "attributes": { "type": "any" } }, { "code": "M285.00", "description": "Cholinergic urticaria", "attributes": { "type": "any" } }, { "code": "M286.00", "description": "Contact urticaria", "attributes": { "type": "any" } }, { "code": "M287.00", "description": "Physical urticaria", "attributes": { "type": "any" } }, { "code": "M28y.00", "description": "Other specified urticaria", "attributes": { "type": "any" } }, { "code": "M28y000", "description": "Urticaria geographica", "attributes": { "type": "any" } }, { "code": "M28y100", "description": "Menstrual urticaria", "attributes": { "type": "any" } }, { "code": "M28y.11", "description": "Nettle rash", "attributes": { "type": "any" } }, { "code": "M28y200", "description": "Urticaria persistans", "attributes": { "type": "any" } }, { "code": "M28yz00", "description": "Other specified urticaria NOS", "attributes": { "type": "any" } }, { "code": "M28z.00", "description": "Urticaria NOS", "attributes": { "type": "any" } }, { "code": "M28z.11", "description": "Hives", "attributes": { "type": "any" } }, { "code": "Myu4.00", "description": "[X]Urticaria and erythema", "attributes": { "type": "any" } }, { "code": "Myu4000", "description": "[X]Other urticaria", "attributes": { "type": "any" } }, { "code": "PH32100", "description": "Urticaria pigmentosa", "attributes": { "type": "any" } }, { "code": "X5050", "description": "Solar urticaria", "attributes": { "type": "any" } }, { "code": "X508P", "description": "Physical urticaria", "attributes": { "type": "any" } }, { "code": "XE1BR", "description": "Allergic urticaria", "attributes": { "type": "any" } }, { "code": "XE1BS", "description": "Other specified urticaria", "attributes": { "type": "any" } }, { "code": "XE1BT", "description": "Urticaria NOS", "attributes": { "type": "any" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/y58g-5n07", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9608, "version_name": "Urticaria", "version_date": "2026-06-08T20:22:07.758130Z", "is_published": true, "is_latest": true } ] } ]