[
  {
    "phenotype_id": "PH4392",
    "phenotype_version_id": 9610,
    "name": "Oesophageal varices",
    "definition": "Abnormally dilated veins of the esophagus.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:22:17.970951Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:22:17.965167Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Esophageal varices (disorder)",
        "value": 236467
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      },
      {
        "name": "OPCS4 codes",
        "value": 7
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 11406,
        "concept_version_id": 18891,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4392",
        "phenotype_version_id": 9610,
        "phenotype_name": "Oesophageal varices",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1141",
            "description": "oesophageal varicies",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11407,
        "concept_version_id": 18892,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4392",
        "phenotype_version_id": 9610,
        "phenotype_name": "Oesophageal varices",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I85",
            "description": "Oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I98.2",
            "description": "Oesophageal varices without bleeding in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I98.3",
            "description": "Oesophageal varices with bleeding in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11408,
        "concept_version_id": 18893,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4392",
        "phenotype_version_id": 9610,
        "phenotype_name": "Oesophageal varices",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I85",
            "description": "Oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I98.2",
            "description": "Oesophageal varices without bleeding in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I98.3",
            "description": "Oesophageal varices with bleeding in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11409,
        "concept_version_id": 18894,
        "concept_name": "Operative procedures - main OPCS4",
        "coding_system": {
          "id": 7,
          "name": "OPCS4 codes",
          "description": "OPCS4 codes"
        },
        "phenotype_id": "PH4392",
        "phenotype_version_id": 9610,
        "phenotype_name": "Oesophageal varices",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "G10",
            "description": "Open operations on varices of oesophagus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.1",
            "description": "Disconnection of azygos vein",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.2",
            "description": "Transection of oesophagus using staple gun",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.3",
            "description": "Transection of oesophagus NEC",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.4",
            "description": "Local ligation of varices of oesophagus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.5",
            "description": "Open injection sclerotherapy to varices of oesophagus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.8",
            "description": "Other specified open operations on varices of oesophagus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.9",
            "description": "Unspecified open operations on varices of oesophagus",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G17.4",
            "description": "Endoscopic injection sclerotherapy to varices of oesophagus using rigid oesophagoscope",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G43.7",
            "description": "Fibreoptic endoscopic rubber band ligation of upper gastrointestinal tract varices",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11410,
        "concept_version_id": 18895,
        "concept_name": "Operative procedures - secondary OPCS4",
        "coding_system": {
          "id": 7,
          "name": "OPCS4 codes",
          "description": "OPCS4 codes"
        },
        "phenotype_id": "PH4392",
        "phenotype_version_id": 9610,
        "phenotype_name": "Oesophageal varices",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "G10",
            "description": "G10",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.1",
            "description": "G10.1",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.2",
            "description": "G10.2",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.3",
            "description": "G10.3",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.4",
            "description": "G10.4",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.5",
            "description": "G10.5",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.8",
            "description": "G10.8",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G10.9",
            "description": "G10.9",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G17.4",
            "description": "G17.4",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G43.7",
            "description": "G43.7",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11411,
        "concept_version_id": 18896,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4392",
        "phenotype_version_id": 9610,
        "phenotype_name": "Oesophageal varices",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I85",
            "description": "Oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I98.2",
            "description": "Oesophageal varices without bleeding in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I98.3",
            "description": "Oesophageal varices with bleeding in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11412,
        "concept_version_id": 18897,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4392",
        "phenotype_version_id": 9610,
        "phenotype_name": "Oesophageal varices",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I85",
            "description": "Oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I98.2",
            "description": "Oesophageal varices without bleeding in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "I98.3",
            "description": "Oesophageal varices with bleeding in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 11413,
        "concept_version_id": 18898,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4392",
        "phenotype_version_id": 9610,
        "phenotype_name": "Oesophageal varices",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "7609.00",
            "description": "Open operations on oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7609300.0",
            "description": "Local ligation of oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7609400.0",
            "description": "Open injection sclerotherapy to oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7609y00",
            "description": "Other specified open operation on oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7609y11",
            "description": "Tanner devascularisation for bleeding varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "7609z00",
            "description": "Open operation on oesophageal varices NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "760C300",
            "description": "Fibreoptic endoscopic injection sclerotherapy oesoph varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "760C500",
            "description": "Fibreoptic endoscopic banding of oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "760F300",
            "description": "Rigid oesophagoscopic injection sclerotherapy oesoph varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "760F400",
            "description": "Rigid oesophagoscopic banding of oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "761D800",
            "description": "Fibreopt endoscop rubber band ligation of upper GIT varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G850.00",
            "description": "Oesophageal varices with bleeding",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G851.00",
            "description": "Oesophageal varices without bleeding",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G85..11",
            "description": "Oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G852.00",
            "description": "Oesophageal varices in diseases EC",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G852000",
            "description": "Oesophageal varices with bleeding in diseases EC",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G852100",
            "description": "Oesophageal varices without bleeding in diseases EC",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G852200",
            "description": "Oesophageal varices in cirrhosis of the liver",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G852300",
            "description": "Oesophageal varices in alcoholic cirrhosis of the liver",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G852z00",
            "description": "Oesophageal varices in diseases EC NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G858.00",
            "description": "Oesophageal varices NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Gyu9400",
            "description": "[X]Oesophageal varices in diseases classified elsewhere",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaBM6",
            "description": "Oesophageal varices in cirrhosis of the liver",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaC1d",
            "description": "Oesophageal varices in alcoholic cirrhosis of the liver",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaE6u",
            "description": "Oesophageal varices NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaLdJ",
            "description": "Fibreoptic endoscopic rubber band ligation of upper gastrointestinal tract varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE0CP",
            "description": "Other specified open operation on oesophageal varices",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XE0Vc",
            "description": "Other varicose veins",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/0tf0-d744",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9610,
        "version_name": "Oesophageal varices",
        "version_date": "2026-06-08T20:22:17.981586Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]