[ { "phenotype_id": "PH4397", "phenotype_version_id": 9615, "name": "Venous thromboembolic disease (Excl PE)", "definition": "Obstruction of a vein or veins by a blood clot in the blood stream.\n\nUKB baseline self reported fields.\n", "implementation": "The earliest record across all sources is obtained.\n", "publications": [ { "doi": "https://doi.org/10.1038/s41598-025-05838-9", "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.", "primary": true } ], "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n", "citation_requirements": null, "created": "2026-06-08T20:22:40.550516Z", "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S", "collections": [ { "name": "Phenotype Library", "value": 18 }, { "name": "UK Biobank", "value": 32 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2026-06-08T20:22:40.545743Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "trials": null, "ontology": [ { "name": "Thromboembolism of vein (disorder)", "value": 464741 } ], "phenoflowid": null, "data_sources": [ { "name": "UK Biobank", "value": 13, "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5", "url": "https://healthdatagateway.org/en/dataset/700", "datasource_id": 700 }, { "name": "Patient Episode Dataset for Wales (PEDW)", "value": 40, "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852", "url": "https://healthdatagateway.org/en/dataset/318", "datasource_id": 318 }, { "name": "Scottish Cancer Registry (SMR06)", "value": 417, "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b", "url": "https://healthdatagateway.org/en/dataset/79", "datasource_id": 79 }, { "name": "Cancer Registration Data", "value": 788, "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43", "url": "https://healthdatagateway.org/en/dataset/880", "datasource_id": 880 } ], "endorsements": null, "project_name": null, "coding_system": [ { "name": "UKBioBank codes", "value": 12 }, { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v3", "value": 6 } ], "corresp_author": "Ana Torralbo", "event_date_range": null, "concept_information": [ { "concept_id": 11437, "concept_version_id": 18922, "concept_name": "Non-cancer illness code, self-reported", "coding_system": { "id": 12, "name": "UKBioBank codes", "description": "UKBioBank codes" }, "phenotype_id": "PH4397", "phenotype_version_id": 9615, "phenotype_name": "Venous thromboembolic disease (Excl PE)", "code_attribute_header": [ "type" ], "codes": [ { "code": "1068", "description": "venous thromboembolic disease", "attributes": { "type": "any" } }, { "code": "1094", "description": "deep venous thrombosis (dvt)", "attributes": { "type": "any" } } ] }, { "concept_id": 11438, "concept_version_id": 18923, "concept_name": "Diagnoses - main ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4397", "phenotype_version_id": 9615, "phenotype_name": "Venous thromboembolic disease (Excl PE)", "code_attribute_header": [ "type" ], "codes": [ { "code": "I63.6", "description": "Cerebral infarction due to cerebral venous thrombosis, nonpyogenic", "attributes": { "type": "any" } }, { "code": "I67.6", "description": "Nonpyogenic thrombosis of intracranial venous system", "attributes": { "type": "any" } }, { "code": "I80.1", "description": "Phlebitis and thrombophlebitis of femoral vein", "attributes": { "type": "any" } }, { "code": "I80.2", "description": "Phlebitis and thrombophlebitis of other deep vessels of lower extremities", "attributes": { "type": "any" } }, { "code": "I81", "description": "Portal vein thrombosis", "attributes": { "type": "any" } }, { "code": "I82.0", "description": "Budd-Chiari syndrome", "attributes": { "type": "any" } }, { "code": "I82.2", "description": "Embolism and thrombosis of vena cava", "attributes": { "type": "any" } }, { "code": "I82.3", "description": "Embolism and thrombosis of renal vein", "attributes": { "type": "any" } } ] }, { "concept_id": 11439, "concept_version_id": 18924, "concept_name": "Diagnoses - secondary ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4397", "phenotype_version_id": 9615, "phenotype_name": "Venous thromboembolic disease (Excl PE)", "code_attribute_header": [ "type" ], "codes": [ { "code": "I63.6", "description": "Cerebral infarction due to cerebral venous thrombosis, nonpyogenic", "attributes": { "type": "any" } }, { "code": "I67.6", "description": "Nonpyogenic thrombosis of intracranial venous system", "attributes": { "type": "any" } }, { "code": "I80.1", "description": "Phlebitis and thrombophlebitis of femoral vein", "attributes": { "type": "any" } }, { "code": "I80.2", "description": "Phlebitis and thrombophlebitis of other deep vessels of lower extremities", "attributes": { "type": "any" } }, { "code": "I81", "description": "Portal vein thrombosis", "attributes": { "type": "any" } }, { "code": "I82.0", "description": "Budd-Chiari syndrome", "attributes": { "type": "any" } }, { "code": "I82.2", "description": "Embolism and thrombosis of vena cava", "attributes": { "type": "any" } }, { "code": "I82.3", "description": "Embolism and thrombosis of renal vein", "attributes": { "type": "any" } } ] }, { "concept_id": 11440, "concept_version_id": 18925, "concept_name": "Underlying (primary) cause of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4397", "phenotype_version_id": 9615, "phenotype_name": "Venous thromboembolic disease (Excl PE)", "code_attribute_header": [ "type" ], "codes": [ { "code": "I63.6", "description": "Cerebral infarction due to cerebral venous thrombosis, nonpyogenic", "attributes": { "type": "any" } }, { "code": "I67.6", "description": "Nonpyogenic thrombosis of intracranial venous system", "attributes": { "type": "any" } }, { "code": "I80.1", "description": "Phlebitis and thrombophlebitis of femoral vein", "attributes": { "type": "any" } }, { "code": "I80.2", "description": "Phlebitis and thrombophlebitis of other deep vessels of lower extremities", "attributes": { "type": "any" } }, { "code": "I81", "description": "Portal vein thrombosis", "attributes": { "type": "any" } }, { "code": "I82.0", "description": "Budd-Chiari syndrome", "attributes": { "type": "any" } }, { "code": "I82.2", "description": "Embolism and thrombosis of vena cava", "attributes": { "type": "any" } }, { "code": "I82.3", "description": "Embolism and thrombosis of renal vein", "attributes": { "type": "any" } } ] }, { "concept_id": 11441, "concept_version_id": 18926, "concept_name": "Contributory (secondary) causes of death: ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH4397", "phenotype_version_id": 9615, "phenotype_name": "Venous thromboembolic disease (Excl PE)", "code_attribute_header": [ "type" ], "codes": [ { "code": "I63.6", "description": "Cerebral infarction due to cerebral venous thrombosis, nonpyogenic", "attributes": { "type": "any" } }, { "code": "I67.6", "description": "Nonpyogenic thrombosis of intracranial venous system", "attributes": { "type": "any" } }, { "code": "I80.1", "description": "Phlebitis and thrombophlebitis of femoral vein", "attributes": { "type": "any" } }, { "code": "I80.2", "description": "Phlebitis and thrombophlebitis of other deep vessels of lower extremities", "attributes": { "type": "any" } }, { "code": "I81", "description": "Portal vein thrombosis", "attributes": { "type": "any" } }, { "code": "I82.0", "description": "Budd-Chiari syndrome", "attributes": { "type": "any" } }, { "code": "I82.2", "description": "Embolism and thrombosis of vena cava", "attributes": { "type": "any" } }, { "code": "I82.3", "description": "Embolism and thrombosis of renal vein", "attributes": { "type": "any" } } ] }, { "concept_id": 11442, "concept_version_id": 18927, "concept_name": "GP clinical event records", "coding_system": { "id": 6, "name": "Read codes v3", "description": "Read codes v3" }, "phenotype_id": "PH4397", "phenotype_version_id": 9615, "phenotype_name": "Venous thromboembolic disease (Excl PE)", "code_attribute_header": [ "type" ], "codes": [ { "code": "14A8100", "description": "H/O: Deep Vein Thrombosis", "attributes": { "type": "prevalent" } }, { "code": "8CMWA00", "description": "On deep vein thrombosis care pathway", "attributes": { "type": "any" } }, { "code": "9kg..00", "description": "Deep vein thrombosis - enhanced services administration", "attributes": { "type": "any" } }, { "code": "9kg0.00", "description": "DVT stage 1 service level - enhanced services administration", "attributes": { "type": "any" } }, { "code": "9kg0.11", "description": "DVT enhanced services administration stage 1 service level", "attributes": { "type": "any" } }, { "code": "9kg1.00", "description": "DVT stage 2 service level - enhanced services administration", "attributes": { "type": "any" } }, { "code": "9kg2.00", "description": "DVT stage 3 service level - enhanced services administration", "attributes": { "type": "any" } }, { "code": "F05..00", "description": "Phlebitis and thrombophlebitis of intracranial sinuses", "attributes": { "type": "any" } }, { "code": "F050.00", "description": "Embolism of central nervous system venous sinus", "attributes": { "type": "any" } }, { "code": "F050000", "description": "Embolism cavernous sinus", "attributes": { "type": "any" } }, { "code": "F050100", "description": "Embolism superior longitudinal sinus", "attributes": { "type": "any" } }, { "code": "F050300", "description": "Embolism transverse sinus", "attributes": { "type": "any" } }, { "code": "F051.00", "description": "Thrombosis of central nervous system venous sinuses", "attributes": { "type": "any" } }, { "code": "F051000", "description": "Thrombosis cavernous sinus", "attributes": { "type": "any" } }, { "code": "F051100", "description": "Thrombosis of superior longitudinal sinus", "attributes": { "type": "any" } }, { "code": "F051200", "description": "Thrombosis lateral sinus", "attributes": { "type": "any" } }, { "code": "F051300", "description": "Thrombosis transverse sinus", "attributes": { "type": "any" } }, { "code": "F051z00", "description": "Thrombosis of central nervous system venous sinus NOS", "attributes": { "type": "any" } }, { "code": "F053.00", "description": "Thrombophlebitis of central nervous system venous sinuses", "attributes": { "type": "any" } }, { "code": "F053000", "description": "Thrombophlebitis of cavernous sinus", "attributes": { "type": "any" } }, { "code": "F053100", "description": "Thrombophlebitis of superior longitudinal venous sinus", "attributes": { "type": "any" } }, { "code": "F05z.00", "description": "Phlebitis or thrombophlebitis of CNS venous sinus NOS", "attributes": { "type": "any" } }, { "code": "G676.00", "description": "Nonpyogenic venous sinus thrombosis", "attributes": { "type": "any" } }, { "code": "G676000", "description": "Cereb infarct due cerebral venous thrombosis, nonpyogenic", "attributes": { "type": "any" } }, { "code": "G67A.00", "description": "Cerebral vein thrombosis", "attributes": { "type": "any" } }, { "code": "G801.00", "description": "Deep vein phlebitis and thrombophlebitis of the leg", "attributes": { "type": "any" } }, { "code": "G801.11", "description": "Deep vein thrombosis", "attributes": { "type": "any" } }, { "code": "G801.12", "description": "Deep vein thrombosis, leg", "attributes": { "type": "any" } }, { "code": "G801.13", "description": "DVT - Deep vein thrombosis", "attributes": { "type": "any" } }, { "code": "G801600", "description": "Thrombophlebitis of the femoral vein", "attributes": { "type": "any" } }, { "code": "G801700", "description": "Thrombophlebitis of the popliteal vein", "attributes": { "type": "any" } }, { "code": "G801800", "description": "Thrombophlebitis of the anterior tibial vein", "attributes": { "type": "any" } }, { "code": "G801900", "description": "Thrombophlebitis of the dorsalis pedis vein", "attributes": { "type": "any" } }, { "code": "G801A00", "description": "Thrombophlebitis of the posterior tibial vein", "attributes": { "type": "any" } }, { "code": "G801B00", "description": "Deep vein thrombophlebitis of the leg unspecified", "attributes": { "type": "any" } }, { "code": "G801C00", "description": "Deep vein thrombosis of leg related to air travel", "attributes": { "type": "any" } }, { "code": "G801D00", "description": "Deep vein thrombosis of lower limb", "attributes": { "type": "any" } }, { "code": "G801E00", "description": "Deep vein thrombosis of leg related to intravenous drug use", "attributes": { "type": "any" } }, { "code": "G801F00", "description": "Deep vein thrombosis of peroneal vein", "attributes": { "type": "any" } }, { "code": "G801G00", "description": "Recurrent deep vein thrombosis", "attributes": { "type": "any" } }, { "code": "G801z00", "description": "Deep vein phlebitis and thrombophlebitis of the leg NOS", "attributes": { "type": "any" } }, { "code": "G80y.11", "description": "Phlebitis and/or thrombophlebitis of iliac vein", "attributes": { "type": "any" } }, { "code": "G80y400", "description": "Thrombophlebitis of the common iliac vein", "attributes": { "type": "any" } }, { "code": "G80y500", "description": "Thrombophlebitis of the internal iliac vein", "attributes": { "type": "any" } }, { "code": "G80y600", "description": "Thrombophlebitis of the external iliac vein", "attributes": { "type": "any" } }, { "code": "G80y700", "description": "Thrombophlebitis of the iliac vein unspecified", "attributes": { "type": "any" } }, { "code": "G80y800", "description": "Phlebitis and thrombophlebitis of the iliac vein NOS", "attributes": { "type": "any" } }, { "code": "G81..00", "description": "Portal vein thrombosis", "attributes": { "type": "any" } }, { "code": "G820.00", "description": "Budd - Chiari syndrome (hepatic vein thrombosis)", "attributes": { "type": "any" } }, { "code": "G820.11", "description": "Hepatic vein thrombosis", "attributes": { "type": "any" } }, { "code": "G822.00", "description": "Embolism and thrombosis of the vena cava", "attributes": { "type": "any" } }, { "code": "G822000", "description": "Thrombosis of inferior vena cava", "attributes": { "type": "any" } }, { "code": "G823.00", "description": "Embolism and thrombosis of the renal vein", "attributes": { "type": "any" } }, { "code": "G824.00", "description": "Axillary vein thrombosis", "attributes": { "type": "any" } }, { "code": "G825.00", "description": "Thrombosis of subclavian vein", "attributes": { "type": "any" } }, { "code": "G826.00", "description": "Thrombosis of internal jugular vein", "attributes": { "type": "any" } }, { "code": "G827.00", "description": "Thrombosis of external jugular vein", "attributes": { "type": "any" } }, { "code": "Gyu8000", "description": "[X]Phlebitis+thrombophlebitis/oth deep vessls/low extremites", "attributes": { "type": "any" } }, { "code": "J420200", "description": "Thrombus of the superior mesenteric veins", "attributes": { "type": "any" } }, { "code": "SP12200", "description": "Post operative deep vein thrombosis", "attributes": { "type": "any" } }, { "code": "Xa1oU", "description": "Thrombosis of inferior vena cava", "attributes": { "type": "any" } }, { "code": "Xa6Yr", "description": "Axillary vein thrombosis", "attributes": { "type": "any" } }, { "code": "Xa6Yt", "description": "Cerebral vein thrombosis", "attributes": { "type": "any" } }, { "code": "Xa9Bs", "description": "Deep vein thrombosis of lower limb", "attributes": { "type": "any" } }, { "code": "Xaa2K", "description": "Thrombosis of internal jugular vein", "attributes": { "type": "any" } }, { "code": "Xaa2L", "description": "Thrombosis of external jugular vein", "attributes": { "type": "any" } }, { "code": "XaaBG", "description": "On deep vein thrombosis care pathway", "attributes": { "type": "any" } }, { "code": "XaBMc", "description": "[V] Personal history deep vein thrombosis", "attributes": { "type": "prevalent" } }, { "code": "XaIIo", "description": "Deep vein thrombosis of leg related to air travel", "attributes": { "type": "any" } }, { "code": "XaJxo", "description": "Deep vein thrombosis of leg related to intravenous drug use", "attributes": { "type": "any" } }, { "code": "XaZ43", "description": "Recurrent deep vein thrombosis", "attributes": { "type": "any" } }, { "code": "XaZht", "description": "Thrombosis of subclavian vein", "attributes": { "type": "any" } }, { "code": "XE0VY", "description": "Deep vein phlebitis and thrombophlebitis of the leg", "attributes": { "type": "any" } }, { "code": "XE0VZ", "description": "Other phlebitis and thrombophlebitis", "attributes": { "type": "any" } }, { "code": "ZV12800", "description": "[V] Personal history deep vein thrombosis", "attributes": { "type": "prevalent" } }, { "code": "ZV12811", "description": "[V] Personal history DVT- deep vein thrombosis", "attributes": { "type": "prevalent" } } ] } ], "status": 1, "doi": "https://doi.org/10.48533/nh1e-ae97", "is_deleted": false, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 2, "name": "BHF Data Science Centre Phenotype", "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org", "version_id": 1 }, "versions": [ { "version_id": 9615, "version_name": "Venous thromboembolic disease (Excl PE)", "version_date": "2026-06-08T20:22:40.557169Z", "is_published": true, "is_latest": true } ] } ]