[
  {
    "phenotype_id": "PH4453",
    "phenotype_version_id": 9967,
    "name": "CCU022_1 Myeloproliferative disease",
    "definition": "Phecode 200: Myeloproliferative disease\n",
    "implementation": "",
    "publications": [],
    "validation": "",
    "citation_requirements": "",
    "created": "2026-08-17T03:16:34.259102Z",
    "author": "Liu, H., Mizani, M. A., Zhao, Y., Wood, A., Inouye, M., Price, A. L., Jiang, X., on behalf of the CVD-COVID-UK/COVID-IMPACT Consortium",
    "collections": [
      {
        "name": "BHF Data Science Centre",
        "value": 20
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-08-18T01:45:50.273382Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": [],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": null,
    "endorsements": [],
    "project_name": "",
    "coding_system": [
      {
        "name": "SNOMED  CT codes",
        "value": 9
      },
      {
        "name": "ICD10 codes",
        "value": 4
      }
    ],
    "corresp_author": "",
    "event_date_range": "",
    "concept_information": [
      {
        "concept_id": 11527,
        "concept_version_id": 19012,
        "concept_name": "ICD-10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4453",
        "phenotype_version_id": 9967,
        "phenotype_name": "CCU022_1 Myeloproliferative disease",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "C887",
            "description": "Other malignant immunoproliferative diseases",
            "attributes": null
          },
          {
            "code": "C944",
            "description": "Acute panmyelosis with myelofibrosis",
            "attributes": null
          },
          {
            "code": "D45",
            "description": "Polycythaemia vera",
            "attributes": null
          },
          {
            "code": "D46",
            "description": "Myelodysplastic syndromes",
            "attributes": null
          },
          {
            "code": "D460",
            "description": "Refractory anaemia without ring sideroblasts, so stated",
            "attributes": null
          },
          {
            "code": "D461",
            "description": "Refractory anaemia with ring sideroblasts",
            "attributes": null
          },
          {
            "code": "D462",
            "description": "Refractory anaemia with excess of blasts [RAEB]",
            "attributes": null
          },
          {
            "code": "D464",
            "description": "Refractory anaemia, unspecified",
            "attributes": null
          },
          {
            "code": "D467",
            "description": "Other myelodysplastic syndromes",
            "attributes": null
          },
          {
            "code": "D469",
            "description": "Myelodysplastic syndrome, unspecified",
            "attributes": null
          },
          {
            "code": "D470",
            "description": "Histiocytic and mast cell tumours of uncertain and unknown behaviour",
            "attributes": null
          },
          {
            "code": "D471",
            "description": "Chronic myeloproliferative disease",
            "attributes": null
          },
          {
            "code": "D473",
            "description": "Essential (haemorrhagic) thrombocythaemia",
            "attributes": null
          },
          {
            "code": "D477",
            "description": "Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue",
            "attributes": null
          },
          {
            "code": "D479",
            "description": "Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified",
            "attributes": null
          },
          {
            "code": "D578",
            "description": "Other sickle-cell disorders",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 11528,
        "concept_version_id": 19013,
        "concept_name": "SNOMED",
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          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH4453",
        "phenotype_version_id": 9967,
        "phenotype_name": "CCU022_1 Myeloproliferative disease",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "109991003",
            "description": "Acute myelofibrosis (disorder)",
            "attributes": null
          },
          {
            "code": "109992005",
            "description": "Polycythemia vera (disorder)",
            "attributes": null
          },
          {
            "code": "109993000",
            "description": "Chronic myeloproliferative disorder (clinical) (disorder)",
            "attributes": null
          },
          {
            "code": "109994006",
            "description": "Essential thrombocythemia (disorder)",
            "attributes": null
          },
          {
            "code": "109995007",
            "description": "Myelodysplastic syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "109996008",
            "description": "Myelodysplastic syndrome: Refractory anemia without ringed sideroblasts without excess blasts (disorder)",
            "attributes": null
          },
          {
            "code": "109998009",
            "description": "Myelodysplastic syndrome with ring sideroblasts and single lineage dysplasia (disorder)",
            "attributes": null
          },
          {
            "code": "127047000",
            "description": "Sickle cell-hemoglobin Lepore disease (disorder)",
            "attributes": null
          },
          {
            "code": "127048005",
            "description": "Sickle cell-Hemoglobin O Arab disease (disorder)",
            "attributes": null
          },
          {
            "code": "189509003",
            "description": "Refractory anemia without sideroblasts so stated (disorder)",
            "attributes": null
          },
          {
            "code": "232033003",
            "description": "Sickle cell-hemoglobin C retinopathy (disorder)",
            "attributes": null
          },
          {
            "code": "254290004",
            "description": "Lymphoproliferative disorder following transplantation (disorder)",
            "attributes": null
          },
          {
            "code": "276811008",
            "description": "Gastric lymphoma (disorder)",
            "attributes": null
          },
          {
            "code": "277466009",
            "description": "Lymphoproliferative disorder (disorder)",
            "attributes": null
          },
          {
            "code": "277580004",
            "description": "Non-secretory myeloma (disorder)",
            "attributes": null
          },
          {
            "code": "277597005",
            "description": "Myelodysplastic syndrome with isolated del(5q) (disorder)",
            "attributes": null
          },
          {
            "code": "307340003",
            "description": "Monosomy 7 syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "307617006",
            "description": "Neutrophilic leukemia (disorder)",
            "attributes": null
          },
          {
            "code": "307651005",
            "description": "Myelosclerosis with myeloid metaplasia (disorder)",
            "attributes": null
          },
          {
            "code": "397008008",
            "description": "Aggressive lymphadenopathic mastocytosis with eosinophilia (disorder)",
            "attributes": null
          },
          {
            "code": "397015000",
            "description": "Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease (disorder)",
            "attributes": null
          },
          {
            "code": "397016004",
            "description": "Systemic mast cell disease (disorder)",
            "attributes": null
          },
          {
            "code": "398623004",
            "description": "Refractory anemia with excess blasts (disorder)",
            "attributes": null
          },
          {
            "code": "414791003",
            "description": "Myelodysplastic syndrome unclassified by World Health Organization classification (disorder)",
            "attributes": null
          },
          {
            "code": "415283002",
            "description": "Refractory anemia with excess blasts-1 (disorder)",
            "attributes": null
          },
          {
            "code": "415284008",
            "description": "Refractory anemia with excess blasts-2 (disorder)",
            "attributes": null
          },
          {
            "code": "415285009",
            "description": "Refractory cytopenia with multilineage dysplasia (disorder)",
            "attributes": null
          },
          {
            "code": "415286005",
            "description": "Refractory cytopenia with multilineage dysplasia and ringed sideroblasts (disorder)",
            "attributes": null
          },
          {
            "code": "416638004",
            "description": "Sickle cell-hemoglobin E disease without crisis (disorder)",
            "attributes": null
          },
          {
            "code": "425333006",
            "description": "Myeloproliferative disorder (disorder)",
            "attributes": null
          },
          {
            "code": "425657001",
            "description": "Osteosclerotic myeloma (disorder)",
            "attributes": null
          },
          {
            "code": "52967002",
            "description": "Myelofibrosis (disorder)",
            "attributes": null
          },
          {
            "code": "700057001",
            "description": "Deafness - lymphedema - leukemia syndrome",
            "attributes": null
          },
          {
            "code": "702476004",
            "description": "Therapy-related myelodysplastic syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "705061009",
            "description": "Childhood myelodysplastic syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "70910003",
            "description": "Indolent systemic mastocytosis (disorder)",
            "attributes": null
          },
          {
            "code": "718195003",
            "description": "Inherited predisposition to essential thrombocythemia (disorder)",
            "attributes": null
          },
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            "code": "721302006",
            "description": "Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (disorder)",
            "attributes": null
          },
          {
            "code": "721306009",
            "description": "Therapy related acute myeloid leukemia and myelodysplastic syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "721311006",
            "description": "Systemic Epstein-Barr virus positive T-cell lymphoproliferative disease of childhood (disorder)",
            "attributes": null
          },
          {
            "code": "722290008",
            "description": "Autoimmune lymphoproliferative syndrome with recurrent viral infection (disorder)",
            "attributes": null
          },
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            "code": "722955006",
            "description": "Chronic lymphoproliferative disorder of natural killer cells (disorder)",
            "attributes": null
          },
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            "code": "738527001",
            "description": "Myeloid and/or lymphoid neoplasm associated with platelet derived growth factor receptor alpha rearrangement (disorder)",
            "attributes": null
          },
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            "code": "762316003",
            "description": "Polymorphic lymphoproliferative disorder following transplant (disorder)",
            "attributes": null
          },
          {
            "code": "766045006",
            "description": "Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent (disorder)",
            "attributes": null
          },
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            "code": "766046007",
            "description": "Acute myeloid leukemia and myelodysplastic syndrome related to topoisomerase type 2 inhibitor (disorder)",
            "attributes": null
          },
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            "code": "766048008",
            "description": "Acute myeloid leukemia and myelodysplastic syndrome related to radiation (disorder)",
            "attributes": null
          },
          {
            "code": "771073006",
            "description": "Lymphoproliferative disorder caused by methotrexate (disorder)",
            "attributes": null
          },
          {
            "code": "771309000",
            "description": "Autosomal recessive lymphoproliferative disease (disorder)",
            "attributes": null
          },
          {
            "code": "780817000",
            "description": "Undifferentiated myeloproliferative disease (disorder)",
            "attributes": null
          },
          {
            "code": "783150002",
            "description": "Iatrogenic immunodeficiency-associated lymphoproliferative disorder (disorder)",
            "attributes": null
          },
          {
            "code": "79268002",
            "description": "Polyneuropathy organomegaly endocrinopathy monoclonal gammopathy and skin changes syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "82546001",
            "description": "Reactive immunoproliferative disease (disorder)",
            "attributes": null
          }
        ]
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    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/grws-f052",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "Hongjiao.Liu",
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      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
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        "version_id": 9967,
        "version_name": "CCU022_1 Myeloproliferative disease",
        "version_date": "2026-08-18T01:45:50.282717Z",
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]