[
  {
    "phenotype_id": "PH4466",
    "phenotype_version_id": 9980,
    "name": "CCU022_1 Hypothyroidism",
    "definition": "Phecode 244: Hypothyroidism\n",
    "implementation": "",
    "publications": [],
    "validation": "",
    "citation_requirements": "",
    "created": "2026-08-17T03:39:12.262289Z",
    "author": "Liu, H., Mizani, M. A., Zhao, Y., Wood, A., Inouye, M., Price, A. L., Jiang, X., on behalf of the CVD-COVID-UK/COVID-IMPACT Consortium",
    "collections": [
      {
        "name": "BHF Data Science Centre",
        "value": 20
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-08-18T01:52:37.771742Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": [],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": null,
    "endorsements": [],
    "project_name": "",
    "coding_system": [
      {
        "name": "SNOMED  CT codes",
        "value": 9
      },
      {
        "name": "ICD10 codes",
        "value": 4
      }
    ],
    "corresp_author": "",
    "event_date_range": "",
    "concept_information": [
      {
        "concept_id": 11548,
        "concept_version_id": 19033,
        "concept_name": "ICD-10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4466",
        "phenotype_version_id": 9980,
        "phenotype_name": "CCU022_1 Hypothyroidism",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "E00",
            "description": "Congenital iodine-deficiency syndrome",
            "attributes": null
          },
          {
            "code": "E000",
            "description": "Congenital iodine-deficiency syndrome, neurological type",
            "attributes": null
          },
          {
            "code": "E001",
            "description": "Congenital iodine-deficiency syndrome, myxoedematous type",
            "attributes": null
          },
          {
            "code": "E002",
            "description": "Congenital iodine-deficiency syndrome, mixed type",
            "attributes": null
          },
          {
            "code": "E009",
            "description": "Congenital iodine-deficiency syndrome, unspecified",
            "attributes": null
          },
          {
            "code": "E018",
            "description": "Other iodine-deficiency-related thyroid disorders and allied conditions",
            "attributes": null
          },
          {
            "code": "E02",
            "description": "Subclinical iodine-deficiency hypothyroidism",
            "attributes": null
          },
          {
            "code": "E030",
            "description": "Congenital hypothyroidism with diffuse goitre",
            "attributes": null
          },
          {
            "code": "E031",
            "description": "Congenital hypothyroidism without goitre",
            "attributes": null
          },
          {
            "code": "E032",
            "description": "Hypothyroidism due to medicaments and other exogenous substances",
            "attributes": null
          },
          {
            "code": "E033",
            "description": "Postinfectious hypothyroidism",
            "attributes": null
          },
          {
            "code": "E038",
            "description": "Other specified hypothyroidism",
            "attributes": null
          },
          {
            "code": "E039",
            "description": "Hypothyroidism, unspecified",
            "attributes": null
          },
          {
            "code": "E890",
            "description": "Postprocedural hypothyroidism",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 11549,
        "concept_version_id": 19034,
        "concept_name": "SNOMED",
        "coding_system": {
          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH4466",
        "phenotype_version_id": 9980,
        "phenotype_name": "CCU022_1 Hypothyroidism",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "102871000119101",
            "description": "Hypothyroidism due to thyroiditis (disorder)",
            "attributes": null
          },
          {
            "code": "10718002",
            "description": "Juvenile myxedema (disorder)",
            "attributes": null
          },
          {
            "code": "10809101000119108",
            "description": "Hypothyroidism in childbirth (disorder)",
            "attributes": null
          },
          {
            "code": "111308000",
            "description": "Neurologic form of cretinism (disorder)",
            "attributes": null
          },
          {
            "code": "111566002",
            "description": "Acquired hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "1137378008",
            "description": "Hypothyroidism due to and following radiotherapy (disorder)",
            "attributes": null
          },
          {
            "code": "14779006",
            "description": "Hypothyroidism following external radiotherapy (disorder)",
            "attributes": null
          },
          {
            "code": "18621008",
            "description": "Transient decreased production of T&gt;4&lt; (disorder)",
            "attributes": null
          },
          {
            "code": "190268003",
            "description": "Congenital hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "190277005",
            "description": "Irradiation hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "190279008",
            "description": "Iodine hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "190282003",
            "description": "Hypothyroidism resulting from para-aminosalicylic acid (disorder)",
            "attributes": null
          },
          {
            "code": "190283008",
            "description": "Hypothyroidism resulting from phenylbutazone (disorder)",
            "attributes": null
          },
          {
            "code": "190284002",
            "description": "Hypothyroidism caused by resorcinol (disorder)",
            "attributes": null
          },
          {
            "code": "193212008",
            "description": "Myasthenic syndrome due to hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "215677009",
            "description": "Congenital hypothyroidism with ectopic thyroid (disorder)",
            "attributes": null
          },
          {
            "code": "217710005",
            "description": "Congenital iodine deficiency syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "22558005",
            "description": "Iodide transport defect (disorder)",
            "attributes": null
          },
          {
            "code": "23536000",
            "description": "Iodotyrosyl coupling defect (disorder)",
            "attributes": null
          },
          {
            "code": "237515009",
            "description": "Congenital hypothyroidism without goiter (disorder)",
            "attributes": null
          },
          {
            "code": "237516005",
            "description": "Congenital thyroid hypoplasia (disorder)",
            "attributes": null
          },
          {
            "code": "237517001",
            "description": "Congenital atrophy of thyroid (disorder)",
            "attributes": null
          },
          {
            "code": "237518006",
            "description": "Hypothyroid goiter acquired (disorder)",
            "attributes": null
          },
          {
            "code": "237519003",
            "description": "Autoimmune hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "237521008",
            "description": "Hypothyroidism due to thyroid stimulating hormone receptor blocking antibody (disorder)",
            "attributes": null
          },
          {
            "code": "237523006",
            "description": "Compensated hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "237527007",
            "description": "Postablative hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "237528002",
            "description": "Post-infectious hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "237559000",
            "description": "Thyroid hormone resistance syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "237560005",
            "description": "Generalized thyroid hormone resistance (disorder)",
            "attributes": null
          },
          {
            "code": "237562002",
            "description": "Iodine deficiency syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "237565000",
            "description": "Congenital iodine deficiency syndrome of mixed type (disorder)",
            "attributes": null
          },
          {
            "code": "237566004",
            "description": "Congenital iodine deficiency syndrome of neurological type (disorder)",
            "attributes": null
          },
          {
            "code": "237567008",
            "description": "Subclinical iodine deficiency hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "237695004",
            "description": "Idiopathic thyroid stimulating hormone deficiency (disorder)",
            "attributes": null
          },
          {
            "code": "26692000",
            "description": "Central hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "27059002",
            "description": "Postoperative hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "276630006",
            "description": "Transient hypothyrotropinemia (disorder)",
            "attributes": null
          },
          {
            "code": "278503003",
            "description": "Congenital hypothyroidism with diffuse goiter (disorder)",
            "attributes": null
          },
          {
            "code": "2917005",
            "description": "Transient hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "30229009",
            "description": "Hypothyroidism due to infiltrative disease (disorder)",
            "attributes": null
          },
          {
            "code": "360348000",
            "description": "Pituitary thyroid hormone resistance (disorder)",
            "attributes": null
          },
          {
            "code": "367631000119105",
            "description": "Hypothyroidism caused by drug (disorder)",
            "attributes": null
          },
          {
            "code": "37429009",
            "description": "Hypothalamic hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "40539002",
            "description": "Hypothyroidism following radioiodine therapy (disorder)",
            "attributes": null
          },
          {
            "code": "405629002",
            "description": "Infant hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "405630007",
            "description": "Infant hypothyroidism to 24 months of age (disorder)",
            "attributes": null
          },
          {
            "code": "40930008",
            "description": "Hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "42277004",
            "description": "Transient decreased production of T&gt;3&lt; (disorder)",
            "attributes": null
          },
          {
            "code": "42785009",
            "description": "Hypothyroidism due to cystinosis (disorder)",
            "attributes": null
          },
          {
            "code": "428165003",
            "description": "Hypothyroidism in pregnancy (disorder)",
            "attributes": null
          },
          {
            "code": "43153006",
            "description": "Myxedema (disorder)",
            "attributes": null
          },
          {
            "code": "43507005",
            "description": "Adult myxedema (disorder)",
            "attributes": null
          },
          {
            "code": "440092001",
            "description": "Myxedematous form of endemic cretinism",
            "attributes": null
          },
          {
            "code": "4641009",
            "description": "Myxedema heart disease (disorder)",
            "attributes": null
          },
          {
            "code": "49830003",
            "description": "Hypothyroidism caused by food stuff (disorder)",
            "attributes": null
          },
          {
            "code": "50375007",
            "description": "Thyroid hormone responsiveness defect (disorder)",
            "attributes": null
          },
          {
            "code": "52724003",
            "description": "Iodide oxidation defect (disorder)",
            "attributes": null
          },
          {
            "code": "54823002",
            "description": "Subclinical hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "55838005",
            "description": "Athyrotic hypothyroidism sequence (disorder)",
            "attributes": null
          },
          {
            "code": "56041007",
            "description": "Hypothyroidism due to defect in thyroid hormone synthesis (disorder)",
            "attributes": null
          },
          {
            "code": "57185003",
            "description": "Primary hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "60733007",
            "description": "Hypothyroidism due to amyloidosis (disorder)",
            "attributes": null
          },
          {
            "code": "63115005",
            "description": "Hypothyroidism due to scleroderma (disorder)",
            "attributes": null
          },
          {
            "code": "64491003",
            "description": "Myxedematous form of cretinism (disorder)",
            "attributes": null
          },
          {
            "code": "698577000",
            "description": "Infant hypothyroidism caused by maternal drug (disorder)",
            "attributes": null
          },
          {
            "code": "70225006",
            "description": "Hypothyroidism caused by iodide excess (disorder)",
            "attributes": null
          },
          {
            "code": "702327009",
            "description": "Monocarboxylate transporter 8 deficiency (disorder)",
            "attributes": null
          },
          {
            "code": "715734006",
            "description": "Congenital absence of half of thyroid (disorder)",
            "attributes": null
          },
          {
            "code": "716338001",
            "description": "Muscular pseudohypertrophy and hypothyroidism syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "717334008",
            "description": "Idiopathic congenital hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "718183003",
            "description": "Familial thyroid dyshormonogenesis (disorder)",
            "attributes": null
          },
          {
            "code": "718193005",
            "description": "Peripheral resistance to thyroid hormone (disorder)",
            "attributes": null
          },
          {
            "code": "718194004",
            "description": "Hypothyroidism due to mutation in transcription factor of pituitary development (disorder)",
            "attributes": null
          },
          {
            "code": "718690009",
            "description": "Congenital hypothyroidism due to absence of thyroid gland (disorder)",
            "attributes": null
          },
          {
            "code": "722051004",
            "description": "Obesity colitis hypothyroidism cardiac hypertrophy developmental delay syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "722375007",
            "description": "Bamforth Lazarus syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "722938007",
            "description": "Congenital central hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "722939004",
            "description": "Congenital hypothyroidism due to iodine deficiency (disorder)",
            "attributes": null
          },
          {
            "code": "722940002",
            "description": "Acquired central hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "725462002",
            "description": "Congenital central hypothyroidism due to thyrotropin-releasing hormone receptor deficiency (disorder)",
            "attributes": null
          },
          {
            "code": "75065003",
            "description": "Endemic cretinism (disorder)",
            "attributes": null
          },
          {
            "code": "763890006",
            "description": "Short stature with delayed bone age due to thyroid hormone metabolism deficiency (disorder)",
            "attributes": null
          },
          {
            "code": "771510006",
            "description": "X-linked central congenital hypothyroidism with late-onset testicular enlargement (disorder)",
            "attributes": null
          },
          {
            "code": "78574007",
            "description": "Hypothyroidism due to sarcoidosis (disorder)",
            "attributes": null
          },
          {
            "code": "82598004",
            "description": "Secondary hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "83664006",
            "description": "Idiopathic atrophic hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "83986005",
            "description": "Severe hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "84781002",
            "description": "Sporadic cretinism (disorder)",
            "attributes": null
          },
          {
            "code": "88273006",
            "description": "Iatrogenic hypothyroidism (disorder)",
            "attributes": null
          },
          {
            "code": "89261000",
            "description": "Isolated thyrotropin deficiency (disorder)",
            "attributes": null
          },
          {
            "code": "92978002",
            "description": "Congenital absence of thyroid gland (disorder)",
            "attributes": null
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/bp10-sn75",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "Hongjiao.Liu",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9980,
        "version_name": "CCU022_1 Hypothyroidism",
        "version_date": "2026-08-18T01:52:37.785033Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]