[ { "phenotype_id": "PH447", "phenotype_version_id": 894, "name": "Alcohol Status", "definition": "A cohort study based on primary care data from the QResearch database will include patients with one of the three common tumours: breast, bowel and prostate. The primary outcome will be overall survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare the survival of patients with cancer taking VGSC-inhibiting drugs (including anticonvulsants and class I antiarrhythmic agents) with patients with cancer not exposed to these drugs, adjusting for age and sex. Exposure to VGSC-inhibiting drugs will be defined as having at least one prescription for these drugs prior to cancer diagnosis. High and low exposure groups will be identified based on the length of use. A number of sensitivity and secondary analyses will be conducted.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenburry, Exposure to sodium channel-inhibiting drugs and cancer survival protocol for a cohort study using the QResearch primary care database. BMJ Open, 4:e006604 2014." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:19:42.118773Z", "author": "Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenbury", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:19:42.118800Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Lifestyle risk factor", "value": "4" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "QResearch®", "value": 24, "uid": "777d6ac1-6879-4750-9a85-9e42d28bb8d4", "url": "https://healthdatagateway.org/en/dataset/794", "datasource_id": 794 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/1998 - 31/12/2013", "concept_information": [ { "concept_id": 1806, "concept_version_id": 4750, "concept_name": "Alcohol Status - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH447", "phenotype_version_id": 894, "phenotype_name": "Alcohol Status", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "136", "description": "Alcohol consumption", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1361", "description": "Teetotaller", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1361-1", "description": "Non drinker alcohol", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1361-2", "description": "Non-drinker alcohol", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1362", "description": "Trivial drinker - <1u/day", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1362-1", "description": "Drinks rarely", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1362-2", "description": "Drinks occasionally", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1363", "description": "Light drinker - 1-2u/day", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1364", "description": "Moderate drinker - 3-6u/day", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1365", "description": "Heavy drinker - 7-9u/day", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1366", "description": "Very heavy drinker - >9u/day", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1367", "description": "Stopped drinking alcohol", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1368", "description": "Alcohol consumption unknown", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1369", "description": "Suspect alcohol abuse - denied", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136a", "description": "Increasing risk drinking", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136A", "description": "Ex-trivial drinker (<1u/day)", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136b", "description": "Feels should cut down drinking", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136B", "description": "Ex-light drinker - (1-2u/day)", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136c", "description": "Higher risk drinking", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136C", "description": "Ex-moderate drinker - (3-6u/d)", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136d", "description": "Lower risk drinking", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136D", "description": "Ex-heavy drinker - (7-9u/day)", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136e", "description": "Declines to state current alcohol consumption", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136E", "description": "Ex-very heavy drinker-(>9u/d)", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136F", "description": "Spirit drinker", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136G", "description": "Beer drinker", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136H", "description": "Drinks beer and spirits", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136I", "description": "Drinks wine", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136J", "description": "Social drinker", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136K", "description": "Alcohol intake above recommended sensible limits", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136L", "description": "Alcohol intake within recommended sensible limits", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136M", "description": "Current non drinker", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136N", "description": "Light drinker", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136O", "description": "Moderate drinker", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136P", "description": "Heavy drinker", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136Q", "description": "Very heavy drinker", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136R", "description": "Binge drinker", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136S", "description": "Hazardous alcohol use", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136T", "description": "Harmful alcohol use", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136V", "description": "Alcohol units per week", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136X", "description": "Alcohol units consumed on heaviest drinking day", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136Y", "description": "Drinks in morning to get rid of hangover", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "136Z", "description": "Alcohol consumption NOS", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "E23-2", "description": "Alcohol problem drinking", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON418", "description": "Alcohol intake", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONGR6", "description": "Grade A none drinker or rare", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONGR7", "description": "Grade B 0-20 units/week", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONGR8", "description": "Grade C 21-49 units/week", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONGR9", "description": "Grade D 50 or more units/week", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISNQUN23", "description": "Unsuccessful attempts to reduce alcohol consumption", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQAL1", "description": "Alcohol AUDIT score", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQAL2", "description": "Alcohol reduction-maintain abstinence", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQAU1", "description": "AUDIT score <4 no drinking problem", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQAU2", "description": "AUDIT score >5 alcohol dependence syndrome", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQAU3", "description": "AUDIT score >5 alcohol problem drinker", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQNO6", "description": "Not interested in reducing alcohol", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQOT3", "description": "Other alcohol related information", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQRE13", "description": "Ready to start reducing alcohol", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQTH4", "description": "Thinking about reducing alcohol", "attributes": { "Entity type": "res17: Alcohol status", "Category": "test", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/gptv-n535", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 894, "version_name": "Alcohol Status", "version_date": "2021-10-06T16:19:42.138888Z", "is_published": true, "is_latest": true } ] } ]