[ { "phenotype_id": "PH448", "phenotype_version_id": 896, "name": "BMI", "definition": "A cohort study based on primary care data from the QResearch database will include patients with one of the three common tumours: breast, bowel and prostate. The primary outcome will be overall survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare the survival of patients with cancer taking VGSC-inhibiting drugs (including anticonvulsants and class I antiarrhythmic agents) with patients with cancer not exposed to these drugs, adjusting for age and sex. Exposure to VGSC-inhibiting drugs will be defined as having at least one prescription for these drugs prior to cancer diagnosis. High and low exposure groups will be identified based on the length of use. A number of sensitivity and secondary analyses will be conducted.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenburry, Exposure to sodium channel-inhibiting drugs and cancer survival protocol for a cohort study using the QResearch primary care database. BMJ Open, 4:e006604 2014." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:19:43.330508Z", "author": "Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenbury", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:19:43.330536Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Biomarker", "value": "1" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "QResearch®", "value": 24, "uid": "777d6ac1-6879-4750-9a85-9e42d28bb8d4", "url": "https://healthdatagateway.org/en/dataset/794", "datasource_id": 794 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/1998 - 31/12/2013", "concept_information": [ { "concept_id": 1807, "concept_version_id": 4752, "concept_name": "BMI - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH448", "phenotype_version_id": 896, "phenotype_name": "BMI", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "22K", "description": "Body Mass Index", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22K1", "description": "Body Mass Index normal K/M2", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22K2", "description": "Body Mass Index high K/M2", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22K3", "description": "Body Mass Index low K/M2", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22K4", "description": "Body mass index index 25-29 - overweight", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22K5", "description": "Body mass index 30+ - obesity", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22K6", "description": "Body mass index less than 20", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22K7", "description": "Body mass index 40+ - severely obese", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22K8", "description": "Body mass index 20-24 - normal", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22K9", "description": "Body mass index centile", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22K90", "description": "Baseline body mass index centile", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22KA", "description": "Target body mass index", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "22KB", "description": "Baseline body mass index", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISNQBM1", "description": "BMI centile", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISNQBO29", "description": "Body mass index less than 18.5", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISNQTA9", "description": "Target body mass index", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "JHCBO5", "description": "Body mass index 18.5-24.9", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "PCNQBO1", "description": "Body mass index", "attributes": { "Entity type": "res17: BMI", "Category": "test", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/ej8g-vy60", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 896, "version_name": "BMI", "version_date": "2021-10-06T16:19:43.351505Z", "is_published": true, "is_latest": true } ] } ]