[
  {
    "phenotype_id": "PH450",
    "phenotype_version_id": 900,
    "name": "Breast Cancer",
    "definition": "A cohort study based on primary care data from the QResearch database will include patients with one of the three common tumours: breast, bowel and prostate. The primary outcome will be overall survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare the survival of patients with cancer taking VGSC-inhibiting drugs (including anticonvulsants and class I antiarrhythmic agents) with patients with cancer not exposed to these drugs, adjusting for age and sex. Exposure to VGSC-inhibiting drugs will be defined as having at least one prescription for these drugs prior to cancer diagnosis. High and low exposure groups will be identified based on the length of use. A number of sensitivity and secondary analyses will be conducted.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenburry, Exposure to sodium channel-inhibiting drugs and cancer survival protocol for a cohort study using the QResearch primary care database. BMJ Open, 4:e006604 2014."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2021-10-06T16:19:46.003916Z",
    "author": "Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenbury",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2021-10-06T16:19:46.003945Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "QResearch®",
        "value": 24,
        "uid": "777d6ac1-6879-4750-9a85-9e42d28bb8d4",
        "url": "https://healthdatagateway.org/en/dataset/794",
        "datasource_id": 794
      }
    ],
    "coding_system": [
      {
        "name": "Read codes v2",
        "value": 5
      }
    ],
    "event_date_range": "01/01/1998 - 31/12/2013",
    "concept_information": [
      {
        "concept_id": 1809,
        "concept_version_id": 4756,
        "concept_name": "Breast Cancer - Primary Care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH450",
        "phenotype_version_id": 900,
        "phenotype_name": "Breast Cancer",
        "code_attribute_header": [
          "Entity type",
          "Category",
          "Coding System (Read)"
        ],
        "codes": [
          {
            "code": "B34",
            "description": "Malignant neoplasm of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B340",
            "description": "Malignant neoplasm of nipple and areola of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B3400",
            "description": "Malignant neoplasm of nipple of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B3401",
            "description": "Malignant neoplasm of areola of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B340-99",
            "description": "Ca breast - nipple/central",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B340z",
            "description": "Malignant neoplasm of nipple or areola of female breast NOS",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34-1",
            "description": "Ca female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B341",
            "description": "Malignant neoplasm of central part of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B342",
            "description": "Malignant neoplasm of upper-inner quadrant of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B342-99",
            "description": "Ca breast-upper,inner quadrant",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B343",
            "description": "Malignant neoplasm of lower-inner quadrant of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B343-99",
            "description": "Ca breast-lower,inner quadrant",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B344",
            "description": "Malignant neoplasm of upper-outer quadrant of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B344-99",
            "description": "Ca breast-upper,outer quadrant",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B345",
            "description": "Malignant neoplasm of lower-outer quadrant of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B345-99",
            "description": "Ca breast-lower,outer quadrant",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B346",
            "description": "Malignant neoplasm of axillary tail of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B346-99",
            "description": "Ca breast - axillary tail",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B347",
            "description": "Malignant neoplasm, overlapping lesion of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34-98",
            "description": "Ca breast - NOS",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34-99",
            "description": "Carcinoma breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34y",
            "description": "Malignant neoplasm of other site of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34y0",
            "description": "Malignant neoplasm of ectopic site of female breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34yz",
            "description": "Malignant neoplasm of other site of female breast NOS",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34z",
            "description": "Malignant neoplasm of female breast NOS",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34z-99",
            "description": "Ca breast - NOS",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B35",
            "description": "Malignant neoplasm of male breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B350",
            "description": "Malignant neoplasm of nipple and areola of male breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B3500",
            "description": "Malignant neoplasm of nipple of male breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B3501",
            "description": "Malignant neoplasm of areola of male breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B350z",
            "description": "Malignant neoplasm of nipple or areola of male breast NOS",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B35-99",
            "description": "Ca breast - male",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B35z",
            "description": "Malignant neoplasm of other site of male breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B35z0",
            "description": "Malignant neoplasm of ectopic site of male breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B35zz",
            "description": "Malignant neoplasm of male breast NOS",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B36",
            "description": "Local recurrence of malignant tumour of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B58y0",
            "description": "Secondary malignant neoplasm of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B830",
            "description": "Carcinoma in situ of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B8300",
            "description": "Lobular carcinoma in situ of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B8301",
            "description": "Intraductal carcinoma in situ of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B830-99",
            "description": "Carcinoma in situ breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B933",
            "description": "Neoplasm of uncertain behaviour of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "BA03",
            "description": "Neoplasm of unspecified nature of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "BB94-1",
            "description": "[M]Secretory breast carcinoma",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "Byu6",
            "description": "[X]Malignant neoplasm of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "EMISNQLO13",
            "description": "Local recurrence of malignant tumour of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "HNG0190",
            "description": "[RFC] Breast cancer",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "ZV103",
            "description": "[V]Personal history of malignant neoplasm of breast",
            "attributes": {
              "Entity type": "res17: Breast cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/7wdd-4k22",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 900,
        "version_name": "Breast Cancer",
        "version_date": "2021-10-06T16:19:46.025948Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]