[
  {
    "phenotype_id": "PH451",
    "phenotype_version_id": 902,
    "name": "Cancer",
    "definition": "Introduction:\n\nVoltage-gated sodium channel (VGSC)- inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSCinhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in patients with cancer, but we were unable to control for the cause of death or indication for prescription. The purpose of the present study is to interrogate a different database to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival.\n\n\nMethods and analysis: \n\nA cohort study using primary care data from the Clinical Practice Research Datalink database will include patients with diagnosis of breast, bowel and prostate cancer (13 000). The primary outcome will be cancer-specific survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and class I antiarrhythmic agents) with patients with cancer not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury, Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, 6(e0111661),  2016."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2021-10-06T16:19:47.976214Z",
    "author": "Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2021-10-06T16:19:47.976242Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "Read codes v2",
        "value": 5
      }
    ],
    "event_date_range": "start - 31/12/2014",
    "concept_information": [
      {
        "concept_id": 1810,
        "concept_version_id": 4758,
        "concept_name": "Cancer - Primary Care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH451",
        "phenotype_version_id": 902,
        "phenotype_name": "Cancer",
        "code_attribute_header": [
          "Entity type",
          "Category",
          "Coding System (Read)"
        ],
        "codes": [
          {
            "code": "1427000",
            "description": "H/O: prostate cancer",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1J08.00",
            "description": "Suspected prostate cancer",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "4M0..00",
            "description": "Gleason grading of prostate cancer",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "4M00.00",
            "description": "Gleason prostate grade 2-4 (low)",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "4M01.00",
            "description": "Gleason prostate grade 5-7 (medium)",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "4M02.00",
            "description": "Gleason prostate grade 8-10 (high)",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B13..00",
            "description": "Malignant neoplasm of colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B130.00",
            "description": "Malignant neoplasm of hepatic flexure of colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B131.00",
            "description": "Malignant neoplasm of transverse colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B132.00",
            "description": "Malignant neoplasm of descending colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B133.00",
            "description": "Malignant neoplasm of sigmoid colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B134.00",
            "description": "Malignant neoplasm of caecum",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B134.11",
            "description": "Carcinoma of caecum",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B135.00",
            "description": "Malignant neoplasm of appendix",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B136.00",
            "description": "Malignant neoplasm of ascending colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B137.00",
            "description": "Malignant neoplasm of splenic flexure of colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B138.00",
            "description": "Malignant neoplasm, overlapping lesion of colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B139.00",
            "description": "Hereditary nonpolyposis colon cancer",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B13y.00",
            "description": "Malignant neoplasm of other specified sites of colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B13z.00",
            "description": "Malignant neoplasm of colon NOS",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B13z.11",
            "description": "Colonic cancer",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B14..00",
            "description": "Malignant neoplasm of rectum, rectosigmoid junction and anus",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B140.00",
            "description": "Malignant neoplasm of rectosigmoid junction",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B141.00",
            "description": "Malignant neoplasm of rectum",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B141.11",
            "description": "Carcinoma of rectum",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B141.12",
            "description": "Rectal carcinoma",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B142.00",
            "description": "Malignant neoplasm of anal canal",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B142000",
            "description": "Malignant neoplasm of cloacogenic zone",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B142.11",
            "description": "Anal carcinoma",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B143.00",
            "description": "Malignant neoplasm of anus unspecified",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B14y.00",
            "description": "Malig neop other site rectum, rectosigmoid junction and anus",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B14z.00",
            "description": "Malignant neoplasm rectum,rectosigmoid junction and anus NOS",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B1z0.11",
            "description": "Cancer of bowel",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34..00",
            "description": "Malignant neoplasm of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B340.00",
            "description": "Malignant neoplasm of nipple and areola of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B340000",
            "description": "Malignant neoplasm of nipple of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B340100",
            "description": "Malignant neoplasm of areola of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B340z00",
            "description": "Malignant neoplasm of nipple or areola of female breast NOS",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B341.00",
            "description": "Malignant neoplasm of central part of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34..11",
            "description": "Ca female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B342.00",
            "description": "Malignant neoplasm of upper-inner quadrant of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B343.00",
            "description": "Malignant neoplasm of lower-inner quadrant of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B344.00",
            "description": "Malignant neoplasm of upper-outer quadrant of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B345.00",
            "description": "Malignant neoplasm of lower-outer quadrant of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B346.00",
            "description": "Malignant neoplasm of axillary tail of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B347.00",
            "description": "Malignant neoplasm, overlapping lesion of breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34y.00",
            "description": "Malignant neoplasm of other site of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34y000",
            "description": "Malignant neoplasm of ectopic site of female breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34yz00",
            "description": "Malignant neoplasm of other site of female breast NOS",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B34z.00",
            "description": "Malignant neoplasm of female breast NOS",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B35..00",
            "description": "Malignant neoplasm of male breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B350.00",
            "description": "Malignant neoplasm of nipple and areola of male breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B350000",
            "description": "Malignant neoplasm of nipple of male breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B350100",
            "description": "Malignant neoplasm of areola of male breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B35z.00",
            "description": "Malignant neoplasm of other site of male breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B35z000",
            "description": "Malignant neoplasm of ectopic site of male breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B35zz00",
            "description": "Malignant neoplasm of male breast NOS",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B36..00",
            "description": "Local recurrence of malignant tumour of breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B46..00",
            "description": "Malignant neoplasm of prostate",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B575.00",
            "description": "Secondary malignant neoplasm of large intestine and rectum",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B575000",
            "description": "Secondary malignant neoplasm of colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B575100",
            "description": "Secondary malignant neoplasm of rectum",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B575z00",
            "description": "Secondary malig neop of large intestine or rectum NOS",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B58y000",
            "description": "Secondary malignant neoplasm of breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B58y500",
            "description": "Secondary malignant neoplasm of prostate",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B7C2000",
            "description": "Adenoma of prostate",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803.00",
            "description": "Carcinoma in situ of colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803000",
            "description": "Carcinoma in situ of hepatic flexure of colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803100",
            "description": "Carcinoma in situ of transverse colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803200",
            "description": "Carcinoma in situ of descending colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803300",
            "description": "Carcinoma in situ of sigmoid colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803400",
            "description": "Carcinoma in situ of caecum",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803500",
            "description": "Carcinoma in situ of appendix",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803600",
            "description": "Carcinoma in situ of ascending colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803700",
            "description": "Carcinoma in situ of splenic flexure of colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803800",
            "description": "High grade dysplasia of colon",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B803z00",
            "description": "Carcinoma in situ of colon NOS",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B804.00",
            "description": "Carcinoma in situ of rectum and rectosigmoid junction",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B804000",
            "description": "Carcinoma in situ of rectosigmoid junction",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B804100",
            "description": "Carcinoma in situ of rectum",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B804z00",
            "description": "Carcinoma in situ of rectum or rectosigmoid junction NOS",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B830.00",
            "description": "Carcinoma in situ of breast",
            "attributes": {
              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "B830000",
            "description": "Lobular carcinoma in situ of breast",
            "attributes": {
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          },
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          },
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          },
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            }
          },
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            }
          },
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          },
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            }
          },
          {
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              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "BA03.00",
            "description": "Neoplasm of unspecified nature of breast",
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              "Entity type": "res47: Cancer",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "BB94.11",
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            }
          },
          {
            "code": "Byu6.00",
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              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "ZV10415",
            "description": "[V]Personal history of malignant neoplasm of prostate",
            "attributes": {
              "Entity type": "res47: Cancer",
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              "Coding System (Read)": "Read"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/9kyf-zp32",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
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    },
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      {
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]