[ { "phenotype_id": "PH459", "phenotype_version_id": 918, "name": "Physical Activity", "definition": "Introduction:\n\nVoltage-gated sodium channel (VGSC)- inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSCinhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in patients with cancer, but we were unable to control for the cause of death or indication for prescription. The purpose of the present study is to interrogate a different database to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival.\n\n\nMethods and analysis: \n\nA cohort study using primary care data from the Clinical Practice Research Datalink database will include patients with diagnosis of breast, bowel and prostate cancer (13 000). The primary outcome will be cancer-specific survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and class I antiarrhythmic agents) with patients with cancer not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury, Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, 6(e0111661), 2016." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:20:39.289811Z", "author": "Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:20:39.289839Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Lifestyle risk factor", "value": "4" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "start - 31/12/2014", "concept_information": [ { "concept_id": 1818, "concept_version_id": 4774, "concept_name": "Physical Activity - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH459", "phenotype_version_id": 918, "phenotype_name": "Physical Activity", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "1381.00", "description": "Exercise physically impossible", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1382.00", "description": "Avoids even trivial exercise", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1383.00", "description": "Enjoys light exercise", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1384.00", "description": "Enjoys moderate exercise", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1385.00", "description": "Enjoys heavy exercise", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1386.00", "description": "Competitive athlete", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1388.00", "description": "Aerobic exercise 0 times/week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1389.00", "description": "Aerobic exercise 1 time/week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138a.00", "description": "GPPAQ physical activity index: moderately active", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138A.00", "description": "Aerobic exercise 2 times/week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138b.00", "description": "GPPAQ physical activity index: active", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138B.00", "description": "Aerobic exercise 3+ times/week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138C.00", "description": "Anaerobic exercise 0 times/wk", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138D.00", "description": "Anaerobic exercise 1 time/week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138E.00", "description": "Anaerobic exercise 2 times/wk", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138F.00", "description": "Anaerobic exercise 3+ times/wk", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138G.00", "description": "Attends exercise classes", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138H.00", "description": "Enjoys intermediate exercise", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138I.00", "description": "FITT activity level 0; no mod/vig activity of 20 mins duratn", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138J.00", "description": "FITT activity level 1; 1-4 occas of mod/vig activit in 4 wks", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138K.00", "description": "FITT activity level 2; 5-11 occas of mod/vig activt in 4 wks", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138L.00", "description": "FITT activity level 3; 12+ occas of mod activity in 4 weeks", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138M.00", "description": "FITT activity level 4; 12+ occas of mod/vig activit in 4 wks", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138N.00", "description": "FITT activity level 5; 12+ occas of vig activity in 4 weeks", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138O.00", "description": "Takes inadequate exercise", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138P.00", "description": "Aerobic exercise three times a week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138Q.00", "description": "Aerobic exercise four times a week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138R.00", "description": "Aerobic exercise five times a week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138S.00", "description": "Declined referral to physical exercise programme", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138T.00", "description": "30 mins/day of at least mod intensty physc activity >=5 week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138V.00", "description": "30 minutes a day of at least moderate intensity walk >=5week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138W.00", "description": "Less than 30 mins/day of at least mod int physc act >=5 week", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138X.00", "description": "GPPAQ physical activity index: inactive", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "138Y.00", "description": "GPPAQ physical activity index: moderately inactive", "attributes": { "Entity type": "res47: Physical activity", "Category": "test", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/c5k3-0j81", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 918, "version_name": "Physical Activity", "version_date": "2021-10-06T16:20:39.311293Z", "is_published": true, "is_latest": true } ] } ]